Background: COVID-19 has become one of the most important occupational diseases for nurses who are in close contact with patients during the pandemic period. Objectives: It was carried out to determine the working conditions and occupational safety knowledge levels of nurses during the pandemic process. Methods: The sample of the study consists of 184 nurses who work actively in Gaziantep 25 December state hospital, who are not on unpaid leave and maternity leave, and who voluntarily participated in the study. Results: It was determined that 70.7% of the nurses were women, 40.8% worked in services, 60.3% received training on occupational health and safety during the pandemic process, and 38% worked 48 hours or more per week. According to the findings, the maximum score that can be obtained from the scale was 270, the mean score of the nurses was 123.64±32.07, the highest score was obtained from the occupational diseases and complaints, and the lowest score was obtained from the accidents and poisoning subscale. Conclusion: It is necessary to establish an attitude towards occupational health and safety for nurses working in hospitals and to provide necessary legal regulations. Working hours should be regulated not to exceed 8 hours, hospitals should be inspected at regular intervals, occupational safety specialists should be made compulsory in hospitals, and working nurses should be screened for occupational diseases at certain intervals.Background: COVID-19 has become one of the most important occupational diseases for nurses who are in close contact with patients during the pandemic period. Objectives: It was carried out to determine the working conditions and occupational safety knowledge levels of nurses during the pandemic process. Methods: The sample of the study consists of 184 nurses who work actively in Gaziantep 25 December state hospital, who are not on unpaid leave and maternity leave, and who voluntarily participated in the study. Results: It was determined that 70.7% of the nurses were women, 40.8% worked in services, 60.3% received training on occupational health and safety during the pandemic process, and 38% worked 48 hours or more per week. According to the findings, the maximum score that can be obtained from the scale was 270, the mean score of the nurses was 123.64±32.07, the highest score was obtained from the occupational diseases and complaints, and the lowest score was obtained from the accidents and poisoning subscale. Conclusion: It is necessary to establish an attitude towards occupational health and safety for nurses working in hospitals and to provide necessary legal regulations. Working hours should be regulated not to exceed 8 hours, hospitals should be inspected at regular intervals, occupational safety specialists should be made compulsory in hospitals, and working nurses should be screened for occupational diseases at certain intervals.