The impact of depression on memory in neurodegenerative disease

Effects of Depression and Parkinson's Disease on Cognitive Functioning

“…Detection of treatable deficits due to depression is important, because treatment of depression may improve the functioning of people with PDD. 2 However, adequate studies are needed to examine changes in cognitive status after successful treatment of depression in Parkinson's disease.…”

“…Half of the PD patients with depression have a major depression and the other half minor depression or dysthymia. [1][2][3][4][5][6] Depression is a risk factor for PD 7 and for dementia in PD, 8,9 and it is associated with more rapid disease progression, 10 cognitive decline, 11 and functional disability. 12 Recent research suggests that mild depression or dysthymia probably has little if any impact on cognition in PD, and that depression must be of at least moderate severity before it has a significant impact on cognition.…”

Clinical neuropsychological assessment in older adults with Lewy body disease and Parkinson's disease.

“…Depression is a risk factor for PD and PDD (Hubble, Cao, Hassanein, Neuberger, & Roller, 1993) and may predate PD by several years (Ishihara & Brayne, 2006). Depression significantly affects cognition and contributes to more rapid cognitive decline in PD (Sano et al, 1989), probably because of the common frontal subcortical pathways and biological correlates they share (Fields, Norman, Straits-Tröster, & Tröster, 1998). Effects of depression on cognition include impairments in executive functions and memory (Kuzis et al, 1999;Norman, Tröster, Fields, & Brooks, 2002), especially in the later stages of PD.…”

Neuropsychology for Movement Disorders Neurosurgery

“…87,91 It has long been recognized that a depressive state can mimic dementia (socalled pseudo-dementia) and this confound must be considered in any evaluation of these patients. 106 In the absence of dementia, patients often suffer from labile effect, which if unrecognized and not managed, can result in an overly pessimistic estimation of cognitive capacity. 28,[107][108][109][110][111] Typically, however, some degree of lability of mood and milder forms of dysthymia-despondancy are expected.…”