The impact of diabetes on left ventricular diastolic function in patients with arterial hypertension

Araz, Murat; Bayrac, Aysen; Çiftçi, Hilmi

doi:10.14744/nci.2015.55477

Cited by 3 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, according to Araz et al,23 the unfavorable effect of concomitant diabetes on LV diastolic function occurs independently of patient sex. Potential mechanisms explaining the effects of sex and type 2 diabetes mellitus on LV diastolic function have been a subject of a recently published review paper 24.…”

Section: Discussionmentioning

confidence: 99%

Sex-specific predictors of left ventricular diastolic dysfunction in untreated hypertension

Jaroch¹,

Vriz²,

Bociąga³

et al. 2016

CIA

View full text Add to dashboard Cite

BackgroundLittle is known about the sex-specific differences in left ventricular (LV) diastolic dysfunction (DD) predictors. We hypothesized that arterial stiffness (AS) may play a different role in the etiology of LV DD in hypertensive men and postmenopausal women, acting independently from other established predictors of this condition, such as age, obesity, diabetes mellitus, LV remodeling, and systolic function.ObjectivesThe aim of the study was to analyze the sex-specific differences in AS and other predictors of LV DD in men and postmenopausal women with untreated hypertension (HTN).Patients and methodsThe study included 144 patients (63 postmenopausal women and 81 men, mean age 62.7±6.7 years) with previously untreated HTN and no history of cardiovascular diseases. All patients were subjected to detailed echocardiography, vascular ultrasound, and high-resolution echotracking (eTracking) of carotid arteries.ResultsIn the multivariate analysis, concomitant diabetes mellitus turned out to be an independent predictor of LV DD in women (P=0.02). In turn, two independent predictors of LV DD have been identified in men: S′-tissue Doppler-derived peak LV longitudinal systolic shortening velocity (P=0.001) and β, beta stiffness index (P=0.004).ConclusionThere are sex differences in the predictors of LV DD in untreated HTN. In postmenopausal women, LV DD is mostly determined by diabetes, while in men, it is determined by S′, reflecting LV systolic longitudinal function, and β, a parameter of AS.

show abstract

Section: Discussionmentioning

confidence: 99%

Sex-specific predictors of left ventricular diastolic dysfunction in untreated hypertension

Jaroch¹,

Vriz²,

Bociąga³

et al. 2016

CIA

View full text Add to dashboard Cite

show abstract

“…Основными механизмами формирования диастолической дисфункции у пациентов с сахарным диабетом служат нарушение расслабления ЛЖ и увеличение его жесткости [33,34], которые регистрируются вне зависимости от наличия ишемической болезни сердца и артериальной гипертензии [12,40]. Так, в недавнем исследовании, проведенном Araz M. и соавт., установлено, что распространенность диастолической дисфункции существенно выше у пациентов с гипертонической болезнью в сочетании с СД, чем у пациентов без СД [7].…”

Section: иммунитет и сердце при диабетеunclassified

Immunoregulatory Imbalance and Functional State of the Heart in the Patients With Diabetes Mellitus Type 2

et al. 2018

View full text Add to dashboard Cite

Diabetes mellitus type 2 is one of the most important non-infectious diseases in the modern world, being an important risk factor of cardiovascular disorders. Changes in left ventricular myocardial diastolic function are observed in diabetic patients independently from other comorbidities. Etiology of the heart failure during diabetes mellitus type 2 is multifactorial, exhibiting cellular, molecular and metabolic aspects. However, its pathophysiological mechanisms are not completely understood. The aim of this study was to evaluate numbers of inflammatory T lymphocytes, i.e., T helper type 1 (Th1) and T helper type 17 (Th17) cells, and FoxP3+T regulatory lymphocytes, depending on the functional state of the heart assessed by two-dimensional echocardiography in patients with arterial hypertension and diabetes mellitus type 2. A total of twenty-five patients with a combination of arterial hypertension and diabetes mellitus type 2, and 14 patients with arterial hypertension without carbohydrate disturbances were recruited to a cross-ectional case-control study. All the patients underwent echocardiography with transthoracic access at the M-mode, B-mode and Doppler mode of imaging. We evaluated numbers of Th1 and Th17 lymphocytes by intracellular production of IL-17 and IFNγ by CD4+ lymphocytes, respectively. The numbers of FoxP3+T regulatory lymphocytes were estimated by expression of CD25 and FoxP3 transcription factor. A flow cytometry approach was used in both cases. We revealed some correlations between the numbers of Th17 lymphocytes, FoxP3+T regulatory lymphocytes and functional parameters of myocardium in patients with diabetes mellitus type 2, which were absent in patientswithout carbohydrate impairments. The numbers of FoxP3+T egulatory lymphocytes, Treg/Th17 lymphocyte ratio, and mean fluorescence intensity of IL-17 for Th17 cells was lower in patients with diabetes mellitus and diastolic dysfunction compared to the patients with diabetes free of diastolic dysfunction. Association of diastolic dysfunction with diabetes mellitus type 2 was accompanied by increase of IFNγ+Th1 lymphocyte numbers and concentrations of IL-10, IFNγ and TNFα in serum as compared to the patients with diastolic dysfunction in the absence of carbohydrate metabolism disturbances. The diabetic patients with diastolic dysfunction were characterized by hyperinsulinemia, hyperglycemia, higher index of insulin resistance, increase of waist circumference and visceral adiposity index when compared to the patients with diastolic dysfunction without diabetes. Visceral obesity and decrease of insulin sensitivity may be regarded as pathogenetically significant factors for the development of immune regulatory imbalance and diastolic dysfunction in the patients with diabetes mellitus type 2.

show abstract

“…Не исключено, что поражение БЛС при диабете может быть и вторичным на фоне присоединившейся патологии сердечно-сосудистой системы, свойственной пациентам с диабетом. На сегодняшний день убедительно доказано, что поражение миокарда у пациентов с СД2 определяется не только атеросклеротическим поражением коронарных артерий, но и специфическими изменениями, которые так свойственны данной категории пациентов, в частности микроангиопатиями [13].…”

unclassified

Dysfunction of respiratory system in patients with diabetes mellitus and coronary artery disease

et al. 2019

View full text Add to dashboard Cite

Aims: we aimed to estimate the main parameters characterizing respiratory pulmonary function in patients with isolated type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD), as well as with their combination. Materials and methods: the study included 198 patients divided into 3 groups: I with isolated CAD [94 (47.5%)], II with T2DM without the signs of CAD [64 (32.3%)], III with combined CAD and T2DM [40 (20.2%)]. The assessment of carbohydrate and lipid metabolism, as well as the measurement of inflammatory markers were performed using unified clinical and biochemical methods. Respiratory pulmonary function and diffusion lung capacity (Dlco) were assessed using Elite Dl-220v body plethysmograph. Results: the parameters reflecting the respiratory pulmonary function and the level of gas diffusion through alveolar-capillary membrane (ACM) in patients with CAD both with and without diabetes was within the normal values. The exception was the level of residual volume, which was below the prognostic values in all the studied groups. At the same time, in diabetic patients with CAD the values of forced and slow vital lung capacity, forced expiratory volume for 1-second, as well as the level of diffusion were significantly lower as compared to the corresponding values in patients with isolated CAD and didnt differ in comparison with the values of diabetic patients except for the level of diffusion. It should be noted that a number of respiratory parameters had a correlation relationships with glycemic level, inflammatory markers and with the indicators characterizing dyslipidemia and myocardial dysfunction. Conclusions: in the course of the study it was found out that the diabetic patients had respiratory system dysfunction in comparison to the patients with isolated CAD. The presence of diabetes in patients with CAD worsens not only the somatic background but probably contributes to the respiratory dysfunction in the form of lower velocity and volumetric parameters, but also in the indicator showing respiratory metabolism.

show abstract

The impact of diabetes on left ventricular diastolic function in patients with arterial hypertension

Cited by 3 publications

References 18 publications

Sex-specific predictors of left ventricular diastolic dysfunction in untreated hypertension

Sex-specific predictors of left ventricular diastolic dysfunction in untreated hypertension

Immunoregulatory Imbalance and Functional State of the Heart in the Patients With Diabetes Mellitus Type 2

Dysfunction of respiratory system in patients with diabetes mellitus and coronary artery disease

Contact Info

Product

Resources

About