“…Moreover, melatonin has been shown to inhibit the expression of stemness-related genes, [ 105 , 128 , 129 ] to inhibit stemness-related pathways [ 105 , 106 ] to improve the response to several anticancer therapies [ 102 , 103 , 130 , 131 , 132 , 133 , 134 ], and to inhibit angiogenesis [ 127 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 ]. Finally, in Androgen Receptor (AR) and Estrogen Receptor (ER) positive cells, melatonin inhibits the AR [ 54 , 65 , 147 , 148 , 149 ] and ER response [ 128 , 150 , 151 , 152 , 153 ] through different mechanisms either mediated by MT1 or independent of MT1 receptor binding.…”