The impact of different flavonoid classes on colonic CI− secretion in rats11Abbreviations: Gt tissue conductance; and Isc short-circuit current.

Cermak, Rainer; Vujicic, Z.; Scharrer, E.; Wolfram, Siegfried

doi:10.1016/s0006-2952(01)00758-4

Cited by 13 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polyphenols with a pyran ring and hydroxyl functional groups increase the solubility of chyme. Quercetin activates fermentation processes, playing a protective role against toxins in food [51]. The metabolism of flavonoids occurs along three paths: oxidation, glucuronisation and sulphonation.…”

Section: Absorption and Metabolism Of Phenolic Acids And Flavonoidsmentioning

confidence: 99%

Polyphenols from Bee Pollen: Structure, Absorption, Metabolism and Biological Activity

et al. 2015

View full text Add to dashboard Cite

Bee pollen constitutes a natural source of antioxidants such as phenolic acids and flavonoids, which are responsible for its biological activity. Research has indicated the correlation between dietary polyphenols and cardioprotective, hepatoprotective, anti-inflammatory, antibacterial, anticancerogenic, immunostimulating, antianaemic effects, as well as their beneficial influence on osseous tissue. The beneficial effects of bee pollen on health result from the presence of phenolic acids and flavonoids which possess anti-inflammatory properties, phytosterol and linolenic acid which play an anticancerogenic role, and polysaccharides which stimulate immunological activity. Polyphenols are absorbed in the alimentary tract, metabolised by CYP450 enzymes, and excreted with urine and faeces. Flavonoids and phenolic acids are characterised by high antioxidative potential, which is closely related to their chemical structure. The high antioxidant potential of phenolic acids is due to the presence and location of hydroxyl groups, a carboxyl group in the immediate vicinity of ortho-diphenolic substituents, and the ethylene group between the phenyl ring and the carboxyl group. As regards flavonoids, essential structural elements are hydroxyl groups at the C5 and C7 positions in the A ring, and at the C3′ and C4′ positions in the B ring, and a hydroxyl group at the C3 position in the C ring. Furthermore, both, the double bond between C2 and C3, and a ketone group at the C4 position in the C ring enhance the antioxidative potential of these compounds. Polyphenols have an ideal chemical structure for scavenging free radicals and for creating chelates with metal ions, which makes them effective antioxidants in vivo.

show abstract

Section: Absorption and Metabolism Of Phenolic Acids And Flavonoidsmentioning

confidence: 99%

Polyphenols from Bee Pollen: Structure, Absorption, Metabolism and Biological Activity

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The epithelium was continuously short‐circuited by an automatic voltage clamp device with correction for solution resistance. Short‐circuit current ( I SC ) and tissue conductance ( G T ) were determined every 6 seconds as described previously (13). An equilibration period of 60 minutes was given before the experiments.…”

Section: Methodsmentioning

confidence: 99%

In Vivo and In Vitro Effects of Tea Extracts on Enterotoxigenic Escherichia coli‐induced Intestinal Fluid Loss in Animal Models

Bruins

Cermak²,

Kiers³

et al. 2006

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

show abstract

“…In this section, we introduce the quercetin action on ENaC expression via stimulation of NKCC1, which regulates transepithelial Cl − secretion and [Cl − ] c by participating in Cl − uptake in epithelial cells [ 77 ]. Quercetin has been reported to stimulate NKCC1 ( Figure 4 ) expressed in neural cells, which mediates uptake of Cl − into the cytosolic space driven by the Na + , K + -ATPase-generated electro-chemical potential of Na + [ 22 , 78 , 79 , 80 ]. The stimulatory action of quercetin on NKCC1 has been also reported in renal epithelial cells [ 14 , 25 , 81 ].…”

Section: Anti-hypertensive Action Of Quercetin Via Down-regulationmentioning

confidence: 99%

Actions of Quercetin, a Polyphenol, on Blood Pressure

et al. 2017

View full text Add to dashboard Cite

Disorder of blood pressure control causes serious diseases in the cardiovascular system. This review focuses on the anti-hypertensive action of quercetin, a flavonoid, which is one of the polyphenols characterized as the compounds containing large multiples of phenol structural units, by varying the values of various blood pressure regulatory factors, such as vascular compliance, peripheral vascular resistance, and total blood volume via anti-inflammatory and anti-oxidant actions. In addition to the anti-inflammatory and anti-oxidant actions of quercetin, we especially describe a novel mechanism of quercetin’s action on the cytosolic Cl− concentration ([Cl−]c) and novel roles of the cytosolic Cl− i.e., (1) quercetin elevates [Cl−]c by activating Na+-K+-2Cl− cotransporter 1 (NKCC1) in renal epithelial cells contributing to Na+ reabsorption via the epithelial Na+ channel (ENaC); (2) the quercetin-induced elevation of [Cl−]c in renal epithelial cells diminishes expression of ENaC leading to a decrease in renal Na+ reabsorption; and (3) this reduction of ENaC-mediated Na+ reabsorption in renal epithelial cells drops volume-dependent elevated blood pressure. In this review, we introduce novel, unique mechanisms of quercetin’s anti-hypertensive action via activation of NKCC1 in detail.

show abstract

The impact of different flavonoid classes on colonic CI− secretion in rats11Abbreviations: Gt tissue conductance; and Isc short-circuit current.

Cited by 13 publications

References 25 publications

Polyphenols from Bee Pollen: Structure, Absorption, Metabolism and Biological Activity

Polyphenols from Bee Pollen: Structure, Absorption, Metabolism and Biological Activity

In Vivo and In Vitro Effects of Tea Extracts on Enterotoxigenic Escherichia coli‐induced Intestinal Fluid Loss in Animal Models

Actions of Quercetin, a Polyphenol, on Blood Pressure

Contact Info

Product

Resources

About