From the perspective of innovation of manufacturing links, this paper conducted research on the current situation of manufacturing development and the relationship between regional economy development and digital transformation, aiming to offer suggestions and reference for relevant policy making. Firstly, taking the INCOPAT patent database as the data source, a quantitative analysis was conducted on the patent data of five key links in the manufacturing industry, which obtained the current situation and digital characteristics of the manufacturing industry development from the perspective of link innovation. Then, based on the relevant economic panel data of regions in China, coupling coordination analysis was conducted to investigate the current characteristics of digital transformation of the five links and the coordinated development of the regional economy from 2017 to 2021. The development level and characteristic relations of 31 provinces or cities in these two systems were analyzed. On the whole, the coordinated development level of the two systems in China is steadily rising but varies among different regions, that is, economically developed regions tend to have better digital transformation development. In general, manufacturing digital transformation in China highly relates to regional economy development. Moreover, the development speed of the two systems tends to be stable from 2017 to 2021. The regions with different coordinated development types should formulate corresponding policies to accelerate manufacturing digital transformation and regional economy development.