Background The coronavirus disease 2019 (COVID-19) pandemic has brought hardship. With the pandemic, there is a need for more health care professionals; yet, premedical students face additional hurdles in applying to medical school. The process of applying to US medical schools before the COVID-19 pandemic was competitive, with an average acceptance rate of 6.7% in 2019. 1 Now with many unforeseen challenges, premedical students applying during 2020, 2021, and subsequent application cycles should be prepared for the changes that the pandemic has necessitated. The COVID-19 pandemic has resulted in a lack of in-person science courses and laboratories, reduced ability for face-toface experiences in shadowing or volunteering, sudden changes to the Medical College Admission Test (MCAT), and changes to deadlines. These changes may impact the next generation of medical students, who will become the next generation of residents, surgeons, and surgeon educators. This perspective will highlight the challenges of applying to medical school during the COVID-19 pandemic and propose evidence-based recommendations to ease the additional burden on the medical school admissions process.