The impact of endogenous Avian Leukosis Viruses (ALVE) on production traits in elite layer lines

Fulton, Janet E.; Mason, Andrew S.; Wolc, Anna; Arango, Jesus; Settar, Peter; Lund, Ashlee R.; Burt, David W.

doi:10.1016/j.psj.2021.101121

Cited by 6 publications

(5 citation statements)

References 59 publications

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“…However, direct and indirect selection against these elements, particularly in commercial layers, has largely eradicated these effects. A recent association analysis suggested only linkage disequilibrium in ALV-E/trait associations, even for integrations such as ALVE3 [Fulton et al, 2021]. The full picture is less simple, as ALV-Es fixed in a population cannot be measured in such studies.…”

Section: Alv-e Representation In Reference Genomesmentioning

confidence: 99%

“…These sequence and SNP chips have also been utilized to identify copy number variants (CNV) [Kranis et al, 2013;Boschiero et al, 2015;Drobik-Czwarno et al, 2018]. This information also has "non-genomic" uses including line characterization, identification of variation within specific genes of interest, development of SNP sets to identify MHC haplotypes [Fulton et al, 2016], identification of retroviral inserts in the chicken genome [Mason et al, 2020b] and their effects on phenotypes [Fulton et al, 2021]. Until recently, deep sequencing had limited use in applied breeding due to its prohibitive cost.…”

Section: Application Of Genomic Information In Layermentioning

confidence: 99%

See 1 more Smart Citation

Fourth Report on Chicken Genes and Chromosomes 2022

Smith¹,

Alfieri²,

Anthony³

et al. 2022

Cytogenet Genome Res

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Section: Alv-e Representation In Reference Genomesmentioning

confidence: 99%

Section: Application Of Genomic Information In Layermentioning

confidence: 99%

Fourth Report on Chicken Genes and Chromosomes 2022

Smith¹,

Alfieri²,

Anthony³

et al. 2022

Cytogenet Genome Res

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show abstract

“…Though devoid of possible pathogenic ability by itself, ALV-E can also boost the incidence of certain lymphomas when present in coinfections with the Marek disease virus, including attenuated vaccine viruses [68], or even to reactivate otherwise-silenced ALV-E in the genome and increase the incidence of spontaneous lymphoid tumors [69]. It has even been reported that ALV-E may be associated with the development of ovarian adenocarcinoma in older hens [70], and the reduction in productivity traits, such as growth rate and body weight in broilers [71][72][73][74][75], as well as albumen height, egg weight, egg production, and sexual maturity in laying hens [71][72][73].…”

Section: Endogenous Alv Subgroupmentioning

confidence: 99%

Avian Leukosis: Will We Be Able to Get Rid of It?

Fandiño,

Gomez-Lucia,

Benítez

et al. 2023

Animals

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Avian leukosis viruses (ALVs) have been virtually eradicated from commercial poultry. However, some niches remain as pockets from which this group of viruses may reemerge and induce economic losses. Such is the case of fancy, hobby, backyard chickens and indigenous or native breeds, which are not as strictly inspected as commercial poultry and which have been found to harbor ALVs. In addition, the genome of both poultry and of several gamebird species contain endogenous retroviral sequences. Circumstances that support keeping up surveillance include the detection of several ALV natural recombinants between exogenous and endogenous ALV-related sequences which, combined with the well-known ability of retroviruses to mutate, facilitate the emergence of escape mutants. The subgroup most prevalent nowadays, ALV-J, has emerged as a multi-recombinant which uses a different receptor from the previously known subgroups, greatly increasing its cell tropism and pathogenicity and making it more transmissible. In this review we describe the ALVs, their different subgroups and which receptor they use to infect the cell, their routes of transmission and their presence in different bird collectivities, and the immune response against them. We analyze the different systems to control them, from vaccination to the progress made editing the bird genome to generate mutated ALV receptors or selecting certain haplotypes.

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“…In addition, the presence of ERVs can also affect the performance of chickens. ALV-E reduces growth rate and body weight in broilers [ 46 , 47 ], as well as albumen height, egg weight, egg production, and sexual maturity in laying hens [ 48 – 50 ]. Not surprisingly, the immune effects of ERVs in poultry genes are contradictory.…”

Section: Endogenous Retroviruses Can Affect Innate Immunitymentioning

confidence: 99%

Advances on genetic and genomic studies of ALV resistance

Wei

et al. 2022

J Animal Sci Biotechnol

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Avian leukosis (AL) is a general term for a variety of neoplastic diseases in avian caused by avian leukosis virus (ALV). No vaccine or drug is currently available for the disease. Therefore, the disease can result in severe economic losses in poultry flocks. Increasing the resistance of poultry to ALV may be one effective strategy. In this review, we provide an overview of the roles of genes associated with ALV infection in the poultry genome, including endogenous retroviruses, virus receptors, interferon-stimulated genes, and other immune-related genes. Furthermore, some methods and techniques that can improve ALV resistance in poultry are discussed. The objectives are willing to provide some valuable references for disease resistance breeding in poultry.

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The impact of endogenous Avian Leukosis Viruses (ALVE) on production traits in elite layer lines

Cited by 6 publications

References 59 publications

Fourth Report on Chicken Genes and Chromosomes 2022

Fourth Report on Chicken Genes and Chromosomes 2022

Avian Leukosis: Will We Be Able to Get Rid of It?

Advances on genetic and genomic studies of ALV resistance

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