The impact of exercise duration and intensity on the release of cardiac biomarkers

Abstract

Numerous studies have observed cardiac biomarker release with prolonged exercise. Despite this, we are unsure as to the constituent aspects of any given exercise bout that may be important in promoting cardiac biomarker release. This study examined the influence of exercise duration and intensity on the appearance of cardiac biomarkers. Twenty-one subjects ran for 45, 90 and 180 min at 85% and 95% of their individual anaerobic threshold on six different days randomized. Cardiac troponin I (cTnI) and N-terminal pro-brain natiuretic peptide (NT-proBNP) were assayed from blood samples collected before, 30 min and 3 h post-exercise. NT-proBNP was elevated after all exercise trials (range before: 21-32; range post: 38-67 ng/L). Peak post-exercise concentrations of NT-proBNP were associated with exercise duration (P=0.049), but not exercise intensity (P=0.451). cTnI was elevated after all exercise trials (range before: 0.007-0.011; range post: 0.008-0.021 μg/L). Peak post-exercise concentrations of cTnI were associated with exercise duration (P=0.003) and intensity (P=0.037). Data suggest that while both cTnI and NT-proBNP increased after all exercise trials, the mediating effect of duration influenced both NT-proBNP and cTnI while intensity influenced only cTnI.

Individual variability of high-sensitivity cardiac troponin levels after aerobic exercise is not mediated by exercise mode

“…The factors that influence the marked inter-and intra-subject variability in the exercise-associated cTn response are not fully understood but could not be explained in our data by exercise mode, duration, intensity, time of day, environment, or number of blood samples. Several previous studies observed a significant association between peak post-exercise cTnI and baseline level Serrano-Ostáriz et al, 2011). This was not the case for hs-cTnT in our study or in others (Legaz-Arrese et al, 2015;Saravia et al, 2010;Tian et al, 2014).…”

The validity of incremental exercise testing in discriminating of physiological profiles in elite runners

“…This increase was found to correlate with exercise intensity (i.e. the more intense the exercise, the larger the increase) (11,25). A protocol involving gradual increases of 2 km.h -1 is not likely to provide enough data density to discriminate between the physiological profiles of elite athletes.…”

“…The determination of the Tlim at the VMLSS or at a specific absolute velocity close to the VMLSS, the determination of the %VO 2max , %VMLSS, and/ or velocity developed for a two-hours duration would be probably more specific tests to evaluate marathon runners. It should be kept in mind that the performance of these types of tests is subject to a large degree of inter-subject variability (6,7,25) and is also sensitive to the effects of training (5). Interestingly, it has been shown that during a two-hour effort, swimmers select a strategy that allows them to develop the highest possible velocity and keep their serum lactate concentration stable (1).…”

Changes of Cardiac Biomarkers after High-intensity Exercise in Male and Female Elite Athletes of Dragon Boating

“… Prolonged strenuous exercise leads to an elevation of cardiac specific biomarkers such as troponin T (TnT), troponin I (TnI), MB-creatine kinase (CKMB) and N-terminal pro brain natriuretic peptide (NT-pro BNP) in apparently healthy endurance athletes [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. These parameters are assumed to indicate cardiac injury or dysfunction [5,18] since troponin T and troponin I are highly specific markers of myocardial cell damage, even in the presence of simultaneous skeletal muscle damage [16].…”