The impact of gallium content on degradation, bioactivity, and antibacterial potency of zinc borate bioactive glass

Yazdi, Alireza Rahimnejad; Torkan, Lawrence; Stone, Wendy; Towler, Mark R.

doi:10.1002/jbm.b.33856

Cited by 36 publications

(24 citation statements)

References 59 publications

(137 reference statements)

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“…A better fit of CTE values was obtained for borate-based glass. This is important to prevent thermal stresses between the glass coatings and this alloy when used in medical implants, which is common.Gallium oxide has been explored as an additive to zinc borate bioactive glasses to confer them with antibacterial properties [199]. The same authors also investigated the suitability of gallium-releasing zinc borate bioactive glasses for osteosarcoma-related bone graft operations using MTT and live/dead assay [200].…”

Section: Bioactive Glasses and Glass-ceramicsmentioning

confidence: 99%

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Bioactive Glasses and Glass-Ceramics for Healthcare Applications in Bone Regeneration and Tissue Engineering

et al. 2018

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The discovery of bioactive glasses (BGs) in the late 1960s by Larry Hench et al. was driven by the need for implant materials with an ability to bond to living tissues, which were intended to replace inert metal and plastic implants that were not well tolerated by the body. Among a number of tested compositions, the one that later became designated by the well-known trademark of 45S5 Bioglass® excelled in its ability to bond to bone and soft tissues. Bonding to living tissues was mediated through the formation of an interfacial bone-like hydroxyapatite layer when the bioglass was put in contact with biological fluids in vivo. This feature represented a remarkable milestone, and has inspired many other investigations aiming at further exploring the in vitro and in vivo performances of this and other related BG compositions. This paradigmatic example of a target-oriented research is certainly one of the most valuable contributions that one can learn from Larry Hench. Such a goal-oriented approach needs to be continuously stimulated, aiming at finding out better performing materials to overcome the limitations of the existing ones, including the 45S5 Bioglass®. Its well-known that its main limitations include: (i) the high pH environment that is created by its high sodium content could turn it cytotoxic; (ii) and the poor sintering ability makes the fabrication of porous three-dimensional (3D) scaffolds difficult. All of these relevant features strongly depend on a number of interrelated factors that need to be well compromised. The selected chemical composition strongly determines the glass structure, the biocompatibility, the degradation rate, and the ease of processing (scaffolds fabrication and sintering). This manuscript presents a first general appraisal of the scientific output in the interrelated areas of bioactive glasses and glass-ceramics, scaffolds, implant coatings, and tissue engineering. Then, it gives an overview of the critical issues that need to be considered when developing bioactive glasses for healthcare applications. The aim is to provide knowledge-based tools towards guiding young researchers in the design of new bioactive glass compositions, taking into account the desired functional properties.

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Section: Bioactive Glasses and Glass-ceramicsmentioning

confidence: 99%

“…Gallium oxide has been explored as an additive to zinc borate bioactive glasses to confer them with antibacterial properties [199]. The same authors also investigated the suitability of gallium-releasing zinc borate bioactive glasses for osteosarcoma-related bone graft operations using MTT and live/dead assay [200].…”

Section: Bioactive Glasses and Glass-ceramicsmentioning

confidence: 99%

Bioactive Glasses and Glass-Ceramics for Healthcare Applications in Bone Regeneration and Tissue Engineering

et al. 2018

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“…Ions such as silver and gallium have demonstrated antibacterial properties [19,20], whereas cobalt can stimulate new blood vessel formation [21,22], similar effect observed in copper-doped glasses [23]. Those ions can be released during the glass dissolution process, improving the glass biological effect.…”

Section: Introductionmentioning

confidence: 96%

Osteogenic potential of sol–gel bioactive glasses containing manganese

Barrioni

Norris

et al. 2019

J Mater Sci: Mater Med

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We report that the release of manganese ions from bioactive glass provoked human mesenchymal stem cell (hMSC) differentiation down a bone pathway, whereas hMSCs exposed to the Mn-free glass did not differentiate. Bioactive glasses (BGs) are widely used for bone regeneration, and allow the incorporation of different ions with therapeutic properties into the glass network. Amongst the different ions with therapeutic benefits, manganese (Mn) has been shown to influence bone metabolism and activate human osteoblasts integrins, improving cell adhesion, proliferation and spreading. Mn has also been incorporated into bioceramics as a therapeutic ion for improved osteogenesis. Here, up to 4.4 mol% MnO was substituted for CaO in the 58S composition (60 mol% SiO2, 36 mol% CaO, 4 mol% P2O5) and its effects on the glass properties and capability to influence the osteogenic differentiation were evaluated. Mncontaining BGs with amorphous structure, high specific surface area and nanoporosity were obtained. The presence of Mn 2+ species was confirmed by X-ray photoelectron spectroscopy (XPS). Mn-containing BGs presented no cytotoxic effect on human mesenchymal stem cells (hMSCs) and enabled sustained ion release in culture medium. hMSCs osteogenic differentiation stimulation and influence on the mineralisation process was also confirmed through the alkaline phosphatase (ALP) activity, and expression of osteogenic differentiation markers, such as collagen type I, osteopontin and osteocalcin, which presented higher expression in the presence of Mn-containing samples compared to control. Mn incorporation offers great promise for obtaining glasses with superior properties for bone tissue regeneration.

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“…Since 1969, when Larry L. Hench discovered 45S5 glass (also known as Bioglass ® ) with nominal composition of: 46.1 SiO 2 , 2.6 P 2 O 5 , 24.4 Na 2 O, 26.9 CaO (in mol %), glass materials have been considered very promising for biomedical applications with their outstanding ability to bond to bone and soft tissues 1,2 . For over 50 years, researchers explored variety of glass compositions, not only silicate 3,4 but also borate‐ 5,6 and phosphate 7 ‐based glasses. However, only two compositions: 45S5 (NovaMin ® , Biogran ® , Novabone ® , Perioglas ® ) 8 and S53P4 (53% SiO 2 , 4% P 2 O 5 , 23% Na 2 O, 20% CaO (in wt.…”

Section: Introductionmentioning

confidence: 99%

Development of microfibers for bone regeneration based on alkali‐free bioactive glasses doped with boron oxide

et al. 2021

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In this paper, we present a new series of alkali‐free bioactive glasses (BG) based on FastOs® composition (38.49 SiO2 – 36.07 CaO – 19.24 MgO – 5.61 P2O5 – 0.59 CaF2, expressed in mol %), which was modified by partially replacing silicon dioxide network‐former with boron trioxide network‐former, utilizing calcium oxide as a charge compensator. The main objective of this study was to obtain a new family of bioactive glasses suitable for the fabrication of glass fibers. The BGs were prepared by melt quenching technique and their structural and thermal properties were determined. Glass rods were used to obtain fibers by the classic drawing technique. The bioactivity of the fibers was subsequently assessed through immersion tests in simulated body fluid (SBF) to establish their ability to form hydroxyl carbonated (HCA) apatite onto their surfaces. Glasses with moderate substitution of SiO2 with B2O3 exhibited enhanced thermal properties, allowing to significantly suppress the crystallization trend, and favoring to draw the fibers. The structure of the studied glasses was obtained by NMR spectroscopy. The structure‐property correlations were established by their relationship to the configurational entropy. Smaller amounts of substitution resulted in larger entropy of the glasses. Moreover the SBF tests revealed an extensive formation of HCA, comparable to the parent FastOs®BG composition, which assures fast bonding to the bone. Thus, presented glass fibers may be considered as promising materials for wool‐like bone implants or as reinforcing constituent of biopolymer matrix composites.

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The impact of gallium content on degradation, bioactivity, and antibacterial potency of zinc borate bioactive glass

Cited by 36 publications

References 59 publications

Bioactive Glasses and Glass-Ceramics for Healthcare Applications in Bone Regeneration and Tissue Engineering

Bioactive Glasses and Glass-Ceramics for Healthcare Applications in Bone Regeneration and Tissue Engineering

Osteogenic potential of sol–gel bioactive glasses containing manganese

Development of microfibers for bone regeneration based on alkali‐free bioactive glasses doped with boron oxide

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