The Impact of Gastric Atrophy on the Incidence of Diabetes

Yu, Tse-Ya; Wei, Jung-Nan; Kuo, Chun‐Heng; Liou, Jyh–Ming; Lin, Ming‐Chung; Shih, Shyang–Rong; Hua, Cyue-Huei; Hsein, Yenh-Chen; Hsu, Ya-Wen; Chuang, Lee‐Ming; Lee, Mei-Kuei; Hsiao, Ching-Hsiang; Wu, Ming–Shiang; Li, Chung‐Yi

doi:10.1038/srep39777

Cited by 12 publications

(10 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The relationship between H. pylori infection and diabetes remained controversial for the last years. Several studies supported our results on the lack of association between H. pylori infection and diabetes [ 17 , 20 , 26 ]. In contrast, others found H. pylori infection to be positively associated with diabetes [ 19 , 21 , 27 , 28 ].…”

Section: Discussionsupporting

confidence: 91%

Association between Helicobacter pylori Infection and Diabetes: A Cross-Sectional Study in China

Man

Jin

et al. 2020

Journal of Diabetes Research

View full text Add to dashboard Cite

Background. Studies suggest an association between H. pylori infection and extragastrointestinal disease. Limited studies provided conflicting results on the association between H. pylori infection and diabetes. The present study was aimed at examining the association between H. pylori infection and diabetes in a large health checkup population in China. Methods. A cross-sectional study was conducted; participants who attended health checkups at Beijing MJ Health Screening Center during 2017-2018 were included. H. pylori infection was diagnosed by 13C-urea breath test. Multivariate logistic regression analysis was performed to evaluate the association between H. pylori infection and diabetes. Results. The mean age of 13,397 participants was 43.8±12 years. The prevalence of H. pylori infection and diabetes was 28.2% and 8.1%, respectively. The prevalence of diabetes was higher among H. pylori-positive participants compared with their counterparts (8.9% vs 7.8%, p=0.05). After adjustment of age, sex, family history of diabetes, smoking, education, stroke, coronary heart disease, BMI, SBP, TG, HDL-C, and LDL-C, multivariate logistic regression analysis found no association between H. pylori infection and diabetes (OR 1.02, 95% CI 0.88-1.18). Additionally, subgroup analysis indicated that H. pylori infection was significantly associated with increased risk of diabetes in the female group (OR 1.09, 95% CI 1.08-1.09). Conclusions. No significant association was found between H. pylori infection and diabetes. However, the subgroup analysis suggested that H. pylori infection was possibly associated with increased risk of diabetes among females. Future cohort studies are needed to verify this association in females and to address possible implication in the prevention of diabetes.

show abstract

Section: Discussionsupporting

confidence: 91%

Association between Helicobacter pylori Infection and Diabetes: A Cross-Sectional Study in China

Man

Jin

et al. 2020

Journal of Diabetes Research

View full text Add to dashboard Cite

show abstract

“…Regarding the association of smoking and H. pylori infection, Endoh and Leung (29) suggested that nicotine reduces gastric mucosal blood flow, epidermal growth factor secretion, and mucus secretion, thus facilitating H. pylori colonization (30). Not every H. pylori infected participant will develop gastric atrophy (11). This aspect could also have influenced our results in the longitudinal analysis, where we did not observe a significant association of H. pylori seropositivity and incident metabolic diseases/risk factors.…”

Section: Discussionmentioning

confidence: 99%

“…A prospective study over 10 years including Latino elderlies living in California found a positive association between seropositive H. pylori status and incident diabetes (10). However, Yu et al reported an impact of gastric atrophy but not of H. pylori infection on the incidence of diabetes (11). Further, the influence of H. pylori infection on the incidence of other metabolic disorders, gastrointestinal diseases without gastric cancer and as well extra-gastric diseases, such as neurological or hematological diseases, asthma, allergies, immune disorders or skin diseases, has been studied widely (3, 9, 12).…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori Seropositivity: Prevalence, Associations, and the Impact on Incident Metabolic Diseases/Risk Factors in the Population-Based KORA Study

Wawro

Amann

Butt

et al. 2019

Front. Public Health

View full text Add to dashboard Cite

Introduction: Helicobacter pylori ( H. pylori ) is a common infection and known risk factor for gastric cancer. We assessed cross-sectional and longitudinal associations to study the impact of H. pylori seropositivity on metabolic diseases. Methods: Helicobacter pylori seropositivity in serum samples of the KORA study was analyzed by multiplex serology. We calculated sex-specific prevalence of H. pylori seropositivity for the year 2007 based on the first follow-up survey (termed F4) of the KORA study S4. We identified factors associated with H. pylori seropositivity in the F4 survey. Further, we assessed relative risks of incident metabolic diseases/risk factors at the time of the second follow-up survey of S4 (termed FF4) and H. pylori seropositivity at the F4 survey as a determinant. Models were adjusted for age, sex, overweight status, physical activity, smoking status, education level, alcohol intake, and other metabolic diseases. Results: Based on 3,037 persons aged 32 to 82 years, the H. pylori prevalence for 2007 was 30.2% in men ( n = 1,465) and 28.1% in women ( n = 1,572). Increasing age, current smoking, low education and no alcohol intake were significantly associated with H. pylori seropositivity in the F4 survey. However, no association between H. pylori seropositivity and BMI, metabolic diseases (type 2 diabetes, hypertension and dyslipidemia, gout or increased uric acid) and gastrointestinal diseases (gastritis, inflammatory bowel disease, and gastric or duodenal ulcer) was observed. No significant associations between H. pylori seropositivity and one of the five investigated incident metabolic diseases/risk factors were detected in the longitudinal analysis. Conclusion: We identified associations between age, smoking, education and alcohol intake and H. pylori seropositivity but no impact of H. pylori seropositivity on incident metabolic diseases/risk factors.

show abstract

“…Gastrointestinal (GI) diseases are the leading cause of morbidity and have a great impact on life 1 – 3 . Stomach disorders of the acid-base balance and various pathogens 4 , 5 can cause many lesions, increasing the probability of triggering cancers 6 – 8 . Hypoacidity of the gastric juice is a dangerous state, which leads to dysbiosis, putrefactive processes, suppression of proteolytic enzyme activation and stomach cancer 9 .…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, it is unknown in which type of stomach cells the NMDARs relevant for GAS regulation are expressed. New insights are needed for understanding the GAS regulating mechanisms and role of NMDARs in the GI tract overall that might allow for targeted selective treatment of stomach diseases 2 , 4 , 5 and oncology 6 – 8 . The significance of GluR research has increased since the discovery that GluRs and, especially, NMDARs are involved in the tumor suppression mechanism 21 , 22 and may be affected by light or so-called low-level laser therapy 23 .…”

Section: Introductionmentioning

confidence: 99%

Peripheral N-methyl-D-aspartate receptor localization and role in gastric acid secretion regulation: immunofluorescence and pharmacological studies

Golovynska

Берегова

Falalyeyeva

et al. 2018

Sci Rep

View full text Add to dashboard Cite

The enteric nervous system (ENS) and a glutamate receptor (GluR), N-methyl-D-aspartate receptor (NMDAR), participate in gastric acid secretion (GAS) regulation. NMDARs are localized in different stomach cells; however, knowledge of NMDAR expression and function in the ENS is limited. In the present study, we clarified the types of stomach cells that express the NMDARs that are involved in GAS regulation. The pharmacological method of isolated stomach perfusion by Ghosh and Shild combined with direct mapping of NMDARs by fluorescence microscopy in the rat stomach was employed. By immunofluorescence labeling with an anti-NMDA-NR1 antibody, NMDARs were found to be highly expressed in nerve cells of the submucosal and myenteric plexuses in the stomach. The exact localization of the NMDARs relevant to GAS and its mechanism of action were determined by stimulating different receptors of neuronal and stomach cells using specific secretagogues for NMDA and by selectively blocking those receptors. NMDARs relevant to GAS stimulation are mainly localized in cholinergic interneurons; however, all of the nerve cells of the submucosal ganglia are involved in the stimulating process. In addition, the NMDARs in parietal cells are involved in gastric acid inhibition via influencing H2-histamine receptors.

show abstract

The Impact of Gastric Atrophy on the Incidence of Diabetes

Cited by 12 publications

References 40 publications

Association between Helicobacter pylori Infection and Diabetes: A Cross-Sectional Study in China

Association between Helicobacter pylori Infection and Diabetes: A Cross-Sectional Study in China

Helicobacter pylori Seropositivity: Prevalence, Associations, and the Impact on Incident Metabolic Diseases/Risk Factors in the Population-Based KORA Study

Peripheral N-methyl-D-aspartate receptor localization and role in gastric acid secretion regulation: immunofluorescence and pharmacological studies

Contact Info

Product

Resources

About