The impact of HSF on endometrium

Bao, Hongchu; Wang, Guichan; Huang, Xin; Wang, Meimei; Wang, Xinrong; Hao, Cuifang

doi:10.1590/1806-9282.63.12.1069

Cited by 10 publications

(12 citation statements)

References 16 publications

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“…Currently, avb3 is one of the strongest evidences of endometrial receptivity markers (37). CE can affect endometrial receptivity in patients with hydrosalpinx (38). In this study, we found that the average AOD of avb3 in the CE group was lower than that in the NCE group (P ¼ .001), indicating that patients with CE have decreased endometrial receptivity.…”

Section: The Influence Of Ce On Endometrial Receptivity and Reproductive Prognosismentioning

confidence: 53%

The impact of chronic endometritis on endometrial fibrosis and reproductive prognosis in patients with moderate and severe intrauterine adhesions: a prospective cohort study

Liu

Yang

Guo

et al. 2019

Fertility and Sterility

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Objective: To study the effect of chronic endometritis (CE) diagnosed by CD138 immunohistochemical (IHC) staining on endometrial fibrosis and reproductive prognosis in patients with moderate or severe intrauterine adhesions (IUAs). Design: Prospective cohort study (Canadian Task Force classification II-2). Setting: University-affiliated hospital. Patient(s): One hundred sixty-seven women with moderate to severe IUAs. Intervention(s): Transcervical resection of adhesions (TCRA) and endometrial biopsy were performed in all patients. According to results of IHC staining with anti-syndecan-1 antibodies to identify CD138 cells, participants were classified into two groups: 78 patients with CE (CE group) and 89 women without CE (NCE group). IHC staining for fibrosis markers transforming growth factor beta 1, antifibrosis markers matrix metalloproteinase 9, and endometrial receptivity marker integrin alpha v beta 3 was later applied to all tissue samples. Main Outcome Measure(s): Endometrial fibrosis, endometrial receptivity, and reproductive prognosis. Result(s): CE diagnosed by CD138 IHC staining has a high incidence, 46%, in moderate and severe IUAs. In the CE group, the expression of transforming growth factor beta 1 was higher than that in the NCE group, and the expression of matrix metalloproteinase 9 and alpha v beta 3 was lower than that in the NCE group. The pregnancy rate and live birth rate in the NCE group were higher than those in the CE group (42.7% vs. 31.5%, 26.9% vs. 17.9%). Conclusion(s): CE may affect the endometrial fibrosis homeostasis in IUAs. Women with CE were more likely to experience recurrence of adhesions and had poorer reproductive outcomes.

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Section: The Influence Of Ce On Endometrial Receptivity and Reproductive Prognosismentioning

confidence: 53%

The impact of chronic endometritis on endometrial fibrosis and reproductive prognosis in patients with moderate and severe intrauterine adhesions: a prospective cohort study

Liu

Yang

Guo

et al. 2019

Fertility and Sterility

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show abstract

“…8 Patients with hydrosalpinx had significantly higher expression of interleukin-2 and tumor necrosis factorα mRNA in endometrial tissue, which play a very important role in inflammatory responses. 8 Chronic endometritis is frequently asymptomatic, and hysteroscopy and immunohistochemistry staining for CD138 of the endometrial biopsy specimens were the main methods in the diagnosis of CE. 12,15 Endometrial hyperemia and micro-polyps might be suggestive of CE.…”

Section: Discussionmentioning

confidence: 97%

“…Hydrosalpinx reduces endometrial receptivity, which lowers the embryo implantation rate 14 . As a type of pelvic inflammatory disease, hydrosalpinx may have strong connection with CE 8 . Patients with hydrosalpinx had significantly higher expression of interleukin‐2 and tumor necrosis factor‐α mRNA in endometrial tissue, which play a very important role in inflammatory responses 8 …”

Section: Discussionmentioning

confidence: 99%

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Correlation between hysteroscopy findings in patients with hydrosalpinx and chronic endometritis

Peng

Guo

Liu

et al. 2021

Intl J Gynecology & Obste

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Chronic endometritis (CE) is a local inflammation of the endometrium that is recognized as the infiltration of plasma cells into endometrial stromal area. 1 The review by Kimura et al. 2 showed that CE occurs in 2.8%-56.8% of infertile patients and in 14%-67.5% of patients with recurrent implantation failure. It was still unclear whether CE had a negative effect on infertility. Research by Kasius et al. 3 showed no

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“…However, when chronic endometritis is identified, antibiotic treatment is associated with resolution in most cases, and subsequent fertility is improved (28). At least one study has identified an association between biomarkers of chronic endometrial inflammation in the presence of a communicating hydrosalpinx (29). If antibiotics resolve hydrosalpinx-related chronic endometritis, surgery may become unnecessary, at least not in some cases.…”

mentioning

confidence: 99%

Is removal of hydrosalpinges prior to in vitro fertilization the standard of care?

Voorhis

Mejia

Schlaff

et al. 2019

Fertility and Sterility

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The impact of HSF on endometrium

Abstract: Chronic endometritis is related to HSF and may therefore affect endometrial receptivity.

Cited by 10 publications

References 16 publications

The impact of chronic endometritis on endometrial fibrosis and reproductive prognosis in patients with moderate and severe intrauterine adhesions: a prospective cohort study

The impact of chronic endometritis on endometrial fibrosis and reproductive prognosis in patients with moderate and severe intrauterine adhesions: a prospective cohort study

Correlation between hysteroscopy findings in patients with hydrosalpinx and chronic endometritis

Is removal of hydrosalpinges prior to in vitro fertilization the standard of care?

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