The impact of hypertension on retinal nerve fiber layer thickness and its association with carotid intima media thickness

Şahin, Osman; Şahin, Serap Baydur; Ayaz, Teslime; Karadağ, Zakir; Türkyılmaz, Kemal; Aktas, Ezgi; Bostan, Mehmet

doi:10.3109/08037051.2014.1000562

Cited by 27 publications

(26 citation statements)

References 38 publications

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“…Previous studies reported contradictory results on the impact of hypertension and blood pressure on pRNFLT 9,23,24 . Our results show reduced pRNFLT in hypertensive patients, but no association of pRNFLT with actual systolic blood pressure.…”

Section: Discussionmentioning

confidence: 94%

Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

et al. 2018

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Section: Discussionmentioning

confidence: 94%

Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

et al. 2018

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“…However, in our study population, age and a history of systemic hypertension generally predicted a considerable decrease in pRNFL thickness. Atherosclerosis in the setting of systemic hypertension appears to be associated with pRNFL thinning [ 21 ]. In addition, the relationship between aging and pRNFL thinning appears robust despite the presence of several confounders.…”

Section: Discussionmentioning

confidence: 99%

Normative Values of Peripapillary Retinal Nerve Fiber Layer Thickness in a Middle Eastern Population

Alsaad

Shatarat

Amarin

et al. 2018

Journal of Ophthalmology

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Purpose Peripapillary retinal nerve fiber layer (pRNFL) thickness is subject to high variability. Normative values of pRNFL thickness remain undocumented in the Middle East. The aim of our study is to assess the normative values of pRNFL thickness in a Middle Eastern population. Methods A retrospective chart review of 74 patients was conducted. Outpatients who had presented to the ophthalmology clinic at the Jordan University Hospital between January 2016 and July 2018 were consecutively sampled. Measurements had been recorded using Fourier-domain optical coherence tomography. Multivariable regression models were developed to generate predicted normative values with adjustments to candidate confounders. Results The mean global pRNFL thickness was 99 ± 11 μm. The mean quadrantic pRNFL thickness increased from the nasal quadrant (75 ± 16 μm) to the temporal (82 ± 20 μm), superior (114 ± 20 μm), and inferior (125 ± 20 μm) quadrants. Gender and eye sidedness did not contribute to the variability in pRNFL thickness. The relationship between aging and pRNFL thinning is independent of diabetes mellitus type 2 and systemic hypertension. Both systemic conditions significantly predicted pRNFL changes despite negative fundoscopic findings. Conclusions Our set of predicted normative data may be used to interpret measurements of pRNFL thickness in Middle Eastern patients. Our findings suggest that systemic conditions with potential ocular manifestations may require consideration in predictive models of pRNFL thickness, even in the absence of gross fundoscopic findings. Normative data from additional Middle Eastern populations are required to appraise our models, which adjust for common clinical confounders.

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“…It provides up to 9 sector measurements rather than average thickness alone for different layers. To date, there are few reports of evaluation of macular thickness and RNFL in patients with systemic sHT (10, 11). All of these reports included the patients with sHT who were receiving antihypertensive medication.…”

Section: Introductionmentioning

confidence: 99%

Retinal Structural Changes in Systemic Arterial Hypertension: An OCT Study

Akay

Gündoğan

Yolcu³

et al. 2016

European Journal of Ophthalmology

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The impact of hypertension on retinal nerve fiber layer thickness and its association with carotid intima media thickness

Abstract: RNFL thickness is reduced in hypertensive patients and may be associated with atherosclerosis.

Cited by 27 publications

References 38 publications

Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

Normative Values of Peripapillary Retinal Nerve Fiber Layer Thickness in a Middle Eastern Population

Retinal Structural Changes in Systemic Arterial Hypertension: An OCT Study

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