The impact of immune-inflammation-nutritional parameters on the prognosis of non-small cell lung cancer patients treated with atezolizumab

Matsubara, Taichi; Takamori, Shinkichi; Haratake, Naoki; Toyozawa, Ryo; Miura, Naruhisa; Shimokawa, Mototsugu; Yamaguchi, Masafumi; Seto, Takashi; Takenoyama, Mitsuhiro

doi:10.21037/jtd.2020.02.27

Cited by 61 publications

(67 citation statements)

References 27 publications

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“…Preoperative nutritional evaluation and support by ERAS nursing program can reduce the incidence of insulin resistance and postoperative hyperglycemia, and reduce preoperative anxiety. The improvement of nutritional status is widely reported to be associated with improved systemic immune function and better prognosis [27,28]. Stoma formation is also a great threat to QOL for LRC patients due to the low acceptance rate, troublesome stoma nursing, and psychological burden.…”

Section: Discussionmentioning

confidence: 99%

Enhanced recovery after surgery nursing program, a protective factor for stoma-related complications in patients with low rectal cancer

et al. 2020

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Background This study aimed to investigate the association between enhanced recovery after surgery (ERAS) nursing program and stoma-related complications (SRCs) and prognosis in patients with low rectal cancer (LRC) undergoing abdominoperineal resection with sigmoidostomy. Methods LRC patients who underwent elective abdominoperineal resection with sigmoidostomy between May 2016 and May 2019 were retrospectively enrolled. The occurrence of early major or minor SRCs (within postoperative 30 days) was set as the primary end-point. Clinicopathological variables and laboratory tests were compared between patients with or without SRCs. The univariate and multivariate logistic regression analyses were performed to investigate risk factors for SRCs. Hospitalization satisfaction-related and prognosis-related variables were compared between LRC patients with or without ERAS nursing program. Results A total of 288 patients were enrolled and the incidence of SRCs was 26.7% (77/288). ERAS nursing program was the only independent risk factor for SRCs in LRC patients (OR 2.04, 95%CI 1.31–3.12, P = 0.016) by the multivariate logistic regression analysis. Moreover, ERAS nursing program was associated with higher hospitalization satisfaction rate, faster bowel function recovery, better psychological status, and higher quality of life. Conclusions ERAS nursing program was a protective factor for SRCs and associated with improved prognosis in LRC patients undergoing elective abdominoperineal resection with sigmoidostomy.

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Section: Discussionmentioning

confidence: 99%

Enhanced recovery after surgery nursing program, a protective factor for stoma-related complications in patients with low rectal cancer

et al. 2020

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show abstract

“…Preoperative nutritional evaluation and support by ERAS nursing can reduce the incidence of insulin resistance and postoperative hyperglycemia, and reduce preoperative anxiety. The improvement of nutritional status is widely reported to be associated with improved systemic immune function and better prognosis (27,28). Stoma formation is also a great threat to QOL for LRC patients due to the low acceptance rate, troublesome stoma nursing, and psychological burden.…”

Section: Discussionmentioning

confidence: 99%

Enhanced recovery after surgery nursing, a risk factor for stoma-related complications in patients with low rectal cancer

Shao

Wang

Chen

et al. 2020

Preprint

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Background: This study aimed to investigate the association between enhanced recovery after surgery (ERAS) nursing and stoma-related complications (SRCs) and prognosis in patients with low rectal cancer (LRC) undergoing abdominoperineal resection with sigmoidostomy.Methods: LRC patients who underwent elective abdominoperineal resection with sigmoidostomy between May 2016 and May 2019 were retrospectively enrolled. The occurrence of early major or minor SRCs (within postoperative 30 days) was set as the primary end-point. Clinicopathological variables and laboratory tests were compared between patients with or without SRCs. The univariate and multivariate logistic regression analyses were performed to investigate risk factors for SRCs. Hospitalization satisfaction-related and prognosis-related variables were compared between LRC patients with or without ERAS nursing.Results: A total of 288 patients were enrolled and the incidence of SRCs was 26.7% (77/288). ERAS nursing was the only independent risk factor for SRCs in LRC patients (OR: 2.04, 95%CI: 1.31-3.12, P=0.016) by the multivariate logistic regression analysis. Moreover, ERAS nursing was associated with higher hospitalization satisfaction rate, faster bowel function recovery, better psychological status, and higher quality of life.Conclusions: ERAS nursing was a risk factor for SRCs and associated with improved prognosis in LRC patients undergoing elective abdominoperineal resection with sigmoidostomy.

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“…Many studies have shown that in ammation is related to the occurrence, development and metastasis of malignant tumors [7][8][9][10][11]. Because the leukocyte count and various types of white blood cells are indicators of systemic in ammation and immune response, these values may be good candidate biomarkers for predicting aggressive tumors.…”

Section: Discussionmentioning

confidence: 99%

The Value of Inflammatory Cell Count and Its Ratio in the Diagnosis of Prostate Cancer

Duan¹,

Xu²,

Deng³

et al. 2020

Preprint

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Background: Inflammatory cells play an important role in the occurrence and development of cancer. In recent years, the value of inflammatory cell count and its ratio in the diagnosis of prostate cancer has been controversial.Methods: A retrospective analysis of 475 patients with transrectal prostate puncture with TPSA>4 ng/ml in the Third Affiliated Hospital of Xi’an Jiaotong University. Univariate analysis, multivariate analysis and Receiver Operating Characteristics curve analysis were performed to analysis the factor of age, TPSA, FPSA, PV, NC, LC, PC, NLR, PLR in the diagnosis value of prostate cancer, and further analysis the value of inflammatory cell count and its ratio in different TPSA groups of prostate cancer (4 ng/ml <TPSA ≤ 10 ng/ml, 10 ng/ml ＜TPSA ≤ 20 ng/ml, TPSA ＞ 20 ng/ml). Results: The results of Univariate analysis in the overall data showed that Age, TPSA, PV, NC, PLC were influencing factors in the diagnosis of prostate cancer. The Area Under the Curve (AUC) of NC was 56.2% with a sensitivity of 72.2% and specificity of 41.5% in the cut -off point of 4.52 (p = 0.021). The PLC cut-off point of 205.5 gives 55.6% AUC with 67.2% sensitivity and 4.2% specificity. Multivariate binary logistic regression analysis results showed that Age, TPSA, PV, NC were independent influencing factors for the diagnosis of prostate cancer; In different TPSA group studies, it was found that NC, NLR, and PLR were valuable for the diagnosis of prostate cancer when TPSA>20 ng/ml，at the NC cut-off point of 4.52 with 67.3% AUC, 71.2% sensitivity and 62.5% specificity(p＜0.001), at the NLR cut-off point of 3.14 with 65.4% AUC, 67.2% sensitivity and 61.1% specificity (p＜0.001), and at the PLR cut-off point of 135.8 with 62.8% AUC , 57.6% sensitivity and 66.7% specificity (p＜0.001). Multivariate binary logistic regression analysis results showed that when TPSA>20 ng/ml, the higher Age, TPSA , Low PV and NC are independent risk factors affecting the diagnosis of prostate cancer. Conclusion: NC has promising value in predicting prostate cancer, especially when TPSA>20 ng/ml. A further prospective study in validating its diagnostic value was needed.

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The impact of immune-inflammation-nutritional parameters on the prognosis of non-small cell lung cancer patients treated with atezolizumab

Cited by 61 publications

References 27 publications

Enhanced recovery after surgery nursing program, a protective factor for stoma-related complications in patients with low rectal cancer

Enhanced recovery after surgery nursing program, a protective factor for stoma-related complications in patients with low rectal cancer

Enhanced recovery after surgery nursing, a risk factor for stoma-related complications in patients with low rectal cancer

The Value of Inflammatory Cell Count and Its Ratio in the Diagnosis of Prostate Cancer

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