The impact of infection and tissue damage in solid-organ transplantation

Chong, Anita S.; Alegre, Maria‐Luisa

doi:10.1038/nri3215

Cited by 138 publications

(114 citation statements)

References 112 publications

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“…These considerations have been largely discussed in the context of organ transplantation by Alegre et al 80 and Chong and Alegre, 81 where infections and/or tissue damage directly or indirectly affect alloreactivity and the outcome of transplanted allografts. Hence, three scenarii can be envisioned to explain how T-cell responses elicited by commensals could influence antitumor immunity.…”

Section: Ly6cmentioning

confidence: 99%

Gut microbiome and anticancer immune response: really hot Sh*t!

Viaud¹,

Daillère²,

Boneca³

et al. 2014

Cell Death Differ

113

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Section: Ly6cmentioning

confidence: 99%

Gut microbiome and anticancer immune response: really hot Sh*t!

Viaud¹,

Daillère²,

Boneca³

et al. 2014

Cell Death Differ

113

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“…Tissue damage posttransplantation can occur through cold ischemia during organ transport and warm ischemia during organ removal and subsequent reperfusion. A central aim in transplantation is to reduce the amount of reperfusion injury 12. IRI posttransplantation is associated with induction of inflammatory cytokines such as TNF‐alpha and IL‐1 13 by graft endothelium, which further triggers polymorphonuclear leukocytes, chemokines, and complement proteins 14, 15.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive Imaging of Activated Complement in Ischemia-Reperfusion Injury Post–Cardiac Transplant

Sharif‐Paghaleh

Yap

Meader

et al. 2015

American Journal of Transplantation

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Ischemia‐reperfusion injury (IRI) is inevitable in solid organ transplantation, due to the transplanted organ being ischemic for prolonged periods prior to transplantation followed by reperfusion. The complement molecule C3 is present in the circulation and is also synthesized by tissue parenchyma in early response to IRI and the final stable fragment of activated C3, C3d, can be detected on injured tissue for several days post‐IRI. Complement activation post‐IRI was monitored noninvasively by single photon emission computed tomography (SPECT) and CT using 99mTc‐recombinant complement receptor 2 (99mTc‐rCR2) in murine models of cardiac transplantation following the induction of IRI and compared to 99mTc‐rCR2 in C3−/− mice or with the irrelevant protein 99mTc‐prostate–specific membrane antigen antibody fragment (PSMA). Significant uptake with 99mTc‐rCR2 was observed as compared to C3−/− or 99mTc‐PSMA. In addition, the transplanted heart to muscle ratio of 99mTc‐rCR2 was significantly higher than 99mTc‐PSMA or C3−/−. The results were confirmed by histology and autoradiography. 99mTc‐rCR2 can be used for noninvasive detection of activated complement and in future may be used to quantify the severity of transplant damage due to complement activation postreperfusion.

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“…There are three types of organ rejection, which are dependent on the speed of rejection following organ transplantation hyperacute, acute and chronic [23]. The main cause of hyperacute rejection is the presence of recipient alloantibodies because of a previous transplantation, blood transfusion, pregnancy, or infection [11].…”

Section: Types Of Rejectionmentioning

confidence: 99%

Untitled

2017

JABB

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Chronic kidney disease (CKD) is the leading cause of death for individuals suffering from end-stage kidney failure. While kidney transplantation is the most viable solution to CKD, it has many challenges and limitations. This review evaluates kidney transplant rejection and the various transplantation methods that may be employed to treat CKD. Kidney rejection and long-term transplant survival is the main concern regarding transplantation attempts. Thus, scientist must screen and strategize appropriately to ensure kidney transplant survival. Tissue engineering techniques are explored as means to improve upon transplantation attempts. Research into ensuring adequate organ scaffold design has become crucial in the field of regenerative medicine. Furthermore, the role of integrins is discussed as a central component for future tissue engineering techniques, by taking the study of scaffold design to the molecular level. Finally, a glimpse into the current advancements of three-dimensional bioprinting highlights the future of tissue engineering and shows how the field of regenerative medicine is taking another step closer to developing "home-grown" kidneys. With the prospect of generating a fully lab-created, personalized kidney, CKD may one day be treated without encountering any of the limitations that have hindered previous attempts.

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The impact of infection and tissue damage in solid-organ transplantation

Cited by 138 publications

References 112 publications

Gut microbiome and anticancer immune response: really hot Sh*t!

Gut microbiome and anticancer immune response: really hot Sh*t!

Noninvasive Imaging of Activated Complement in Ischemia-Reperfusion Injury Post–Cardiac Transplant

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