The Impact of Intraoperative Manipulation of the Prostate on Total and Free Prostate-Specific Antigen

Oberpenning, F.; Schmid, Hans‐Peter; Fuchs-Surdel, W.; Hertle, L.; Semjonow, Axel

doi:10.1177/172460080201700302

Cited by 13 publications

(7 citation statements)

References 33 publications

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“…The present study demonstrated that four (P = 0.00) and six (P = 0.00) weeks of prostatic massage improve PSA in patients with PC, and this is inconsistent with other studies examining the individual effects of prostatic massage after ADT, chronic prostatitis, and radiation therapy (5,26). Likewise, it has been reported that free PSA is the most increased form after prostatic manipulation (5,27). In addition, the current study demonstrated that four (P = 0.00) and eight (P = 0.00) weeks of resistance training reduce PSA.…”

Section: Discussioncontrasting

confidence: 54%

Investigating the Effects of Regular Resistance Training and Prostatic Massage on Proinflammatory Markers and Serum Prostate-Specific Antigen Levels in Males with Prostate Cancer

Shoorabeh

dabidiroshan

Saraf

et al. 2016

Middle East J Rehabil Health

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Background: Prostate cancer (PC) is one of the most common cancers worldwide. Some studies support that chronic inflammation of prostate tissue plays a role in the development of PC. A variety of growth factors and cytokines may lead to proinflammatory processes within the prostate. Objectives: The aim of the present study was to investigate the effects of eight weeks of regular resistance training and prostatic massage on proinflammatory markers) CRP, IL-6, TNF-α, and IL-10 and serum prostate-specific antigen (PSA levels in males with PC). Patients and Methods: Forty-five patients with PC were selected for this study. They were randomized into either the resistance training intervention group (n = 15), the massage intervention group (n = 15), or the control group (n = 15). Resistance-training patients participated in resistance training for eight weeks, and massage was performed for six weeks on the massage group. Repeated measures analysis of variance (ANOVA) was used to analyze the data (P ≤ 0.05). Results: In the resistance training group, IL-10 levels significantly increased after four (P = 0.055) and eight weeks (P = 0.000). Four and eight weeks of resistance training showed a significant reduction in PSA, CRP, IL-6, and TNF-α levels (P < 0.05). Patients of massage intervention showed an increase in IL-10 after four (P = 0.045) and six weeks (P = 0.005). In addition, four and six weeks of massage intervention showed a significant reduction in PSA, CRP, IL-6, and TNF-α levels (P < 0.05). Conclusions: Regular resistance training and prostatic massage can improve proinflammatory markers and PSA levels in men with PC.

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Section: Discussioncontrasting

confidence: 54%

Investigating the Effects of Regular Resistance Training and Prostatic Massage on Proinflammatory Markers and Serum Prostate-Specific Antigen Levels in Males with Prostate Cancer

Shoorabeh

dabidiroshan

Saraf

et al. 2016

Middle East J Rehabil Health

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“…If prior collection is not possible, then it is prudent to delay several days after DRE before drawing blood for PSA, although in most men DRE does not cause a clinically relevant change in circulating PSA concentration (166 ). Following prostate biopsy or surgery, the recommended delay is several weeks to permit sufficient time for the PSA bound as a stable complex to ␣-1-antichymotrypsin to be eliminated from the blood circulation, although the kidneys rapidly clear from the blood any fPSA that was liberated from the prostate by the procedure (208,209 To eliminate in vitro artifacts, blood should be centrifuged within 3 h of collection to isolate the serum or plasma (210 ). Serum and plasma may be kept at refrigerated temperatures for up to 24 h without loss of PSA.…”

Section: Preanalytical Specimen Processing and Storagementioning

confidence: 99%

National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Testicular, Prostate, Colorectal, Breast, and Ovarian Cancers

et al. 2008

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Background: Updated National Academy of Clinical Biochemistry (NACB) Laboratory Medicine Practice Guidelines for the use of tumor markers in the clinic have been developed. Methods: Published reports relevant to use of tumor markers for 5 cancer sites—testicular, prostate, colorectal, breast, and ovarian—were critically reviewed. Results: For testicular cancer, α-fetoprotein, human chorionic gonadotropin, and lactate dehydrogenase are recommended for diagnosis/case finding, staging, prognosis determination, recurrence detection, and therapy monitoring. α-Fetoprotein is also recommended for differential diagnosis of nonseminomatous and seminomatous germ cell tumors. Prostate-specific antigen (PSA) is not recommended for prostate cancer screening, but may be used for detecting disease recurrence and monitoring therapy. Free PSA measurement data are useful for distinguishing malignant from benign prostatic disease when total PSA is <10 μg/L. In colorectal cancer, carcinoembryonic antigen is recommended (with some caveats) for prognosis determination, postoperative surveillance, and therapy monitoring in advanced disease. Fecal occult blood testing may be used for screening asymptomatic adults 50 years or older. For breast cancer, estrogen and progesterone receptors are mandatory for predicting response to hormone therapy, human epidermal growth factor receptor-2 measurement is mandatory for predicting response to trastuzumab, and urokinase plasminogen activator/plasminogen activator inhibitor 1 may be used for determining prognosis in lymph node–negative patients. CA15-3/BR27–29 or carcinoembryonic antigen may be used for therapy monitoring in advanced disease. CA125 is recommended (with transvaginal ultrasound) for early detection of ovarian cancer in women at high risk for this disease. CA125 is also recommended for differential diagnosis of suspicious pelvic masses in postmenopausal women, as well as for detection of recurrence, monitoring of therapy, and determination of prognosis in women with ovarian cancer. Conclusions: Implementation of these recommendations should encourage optimal use of tumor markers.

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“…f-PSA is more sensitive to manipulation and is also cleared from serum faster than t-PSA. Studies evaluating biological clearance rates of f-PSA after surgical removal of the prostate gland suggest a shorter half-life of 22 h (13,14). Studies evaluating biological clearance rates of f-PSA after surgical removal of the prostate gland suggest a shorter half-life of 22 h (13,14).…”

Section: Discussionmentioning

confidence: 99%

The effects of extracorporeal cardiopulmonary circulation on serum total and free prostate specific antigen levels

Aksoy

Aksoy²,

Ceviz³

et al. 2005

Clinical Chemistry and Laboratory Medicine (CCLM)

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The aim of this study was to investigate whether or not there is an increase in serum total and free prostate specific antigen levels (t-PSA, f-PSA) in patients with and without benign prostatic hyperplasia (BPH) undergoing extracorporeal circulation during cardiovascular bypass. The study included a total of 50 men. Of these, 35 patients underwent elective coronary artery bypass grafting with extracorporeal circulation [with (n=20, group I) and without (n=15, group II) BPH]. Another 15 patients underwent renal or ureteral surgery (group III) and served as a control group. Serum t-PSA and f-PSA levels were measured before surgery and 3 h and 3 days after surgery. All patients underwent urethral catheterization 24 h before surgery. In groups I and II, patients had an increase in t-PSA 3 h after surgery compared to baseline values (p=0.0001 and p=0.011, respectively). Also, 3 days after surgery, mean t-PSA levels were higher than baseline levels (p=0.004) in group I. Serum t-PSA levels were higher at 3 h than at day 3 in groups I and II (p=0.003 and p=0.02, respectively). Mean serum f-PSA levels obtained 3 h after surgery were increased in both groups I and II when compared to baseline values (p=0.0001 and p=0.001, respectively). There was no significant difference between f-PSA values before and 3 days after surgery in all groups. In the control group, there was no significant increase in either serum t-PSA or f-PSA levels obtained at different times. There was a modest increase in the percentage of free prostate specific antigen (% f-PSA) 3 h after the operation in group II (p=0.025); the values returned to baseline within 3 days. It was suggested that t-PSA and f-PSA serum levels increase due to extracorporeal cardiopulmonary circulation as a consequence of ischemic damage to the prostate. In patients with BPH, this rise may be higher than in those without BPH, because BPH patients generally have larger prostate volumes that may be more vulnerable to ischemic damage. Because f-PSA has a shorter half-life, postsurgical levels of f-PSA may not show this ischemic damage to the prostate during the late postoperative period and f-PSA appears to be cleared more rapidly than t-PSA.

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The Impact of Intraoperative Manipulation of the Prostate on Total and Free Prostate-Specific Antigen

Cited by 13 publications

References 33 publications

Investigating the Effects of Regular Resistance Training and Prostatic Massage on Proinflammatory Markers and Serum Prostate-Specific Antigen Levels in Males with Prostate Cancer

Investigating the Effects of Regular Resistance Training and Prostatic Massage on Proinflammatory Markers and Serum Prostate-Specific Antigen Levels in Males with Prostate Cancer

National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Testicular, Prostate, Colorectal, Breast, and Ovarian Cancers

The effects of extracorporeal cardiopulmonary circulation on serum total and free prostate specific antigen levels

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