The impact of intrauterine infection on fetal brain damage assessed by S100B protein concentrations in umbilical cord arteries

Masaoka, Naoki; Nakajima, Yoshiyuki; Morooka, Masako; Tashiro, Hidefumi; Wada, M.; Maruta, Kana; Iwane, Eriko; Yamashiro, Miwako

doi:10.3109/14767058.2015.1087501

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…Later, further studies are needed to confirm whether intrauterine infection in pregnant women can also regulate miR-182 expression level through this mechanism. Present studies have confirmed (18–22) that intrauterine infection can cause brain damage in premature infants. Therefore, expression level of miR-182 is closely related to brain injury in premature infants.…”

Section: Discussionsupporting

confidence: 78%

Association of miR-182 expression in amniotic fluid with intrauterine infection and brain injury in premature infants

Gao

Jiang

et al. 2018

Exp Ther Med

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Changes of micro-ribonucleic acid-182 (miR-182) level in cases of intrauterine infection were investigated to explore the association between miR-182 level change and brain injury in premature infants. A total of 257 preterm infants born in obstetrics department of Jinan Maternity and Child Care Hospital from February 2015 to February 2017 were enrolled in this study. These preterm infants were divided into infected group (n=113) and uninfected group (n=144) based on pathological diagnosis results. Quantitative polymerase chain reaction (qPCR) was employed to detect miR-182 level in amniotic fluid. Bregmatic sagittal and coronal plus lateral fontanel craniocerebral ultrasound, craniocerebral computed tomography (CT) and craniocerebral magnetic resonance imaging examinations were conducted in these preterm infants within one week after birth, and the results were recorded. The relationship between intrauterine infection and brain injury in premature infants was analyzed, and the association of miR-182 level with brain injury was explored. According to pathological diagnoses, brain injury was found in 61 of 113 infants in the infected group, with an incidence rate of 54.0%; and 28 of 144 infants in uninfected group, with an incidence rate of 19.4%; among them, 3 had placental infection caused by intrauterine infection in pregnant women, and all preterm infants had brain damage. Risk value of brain injury in premature infants due to intrauterine infection was hazard ratio (HR) = 2.2611, χ2=33.798, P<0.02. Infected group had a higher miR-182 level in comparison with uninfected group, and the difference in miR-182 level between infected group and uninfected group was statistically significant (P<0.05). Intrauterine infection can lead to an increase in miR-182 level; growth in miR-182 level is closely related to brain injury in premature infants.

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Section: Discussionsupporting

confidence: 78%

Association of miR-182 expression in amniotic fluid with intrauterine infection and brain injury in premature infants

Gao

Jiang

et al. 2018

Exp Ther Med

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“…[6] As cytokines can go through the placenta and the blood-brain barrier to affect the fetal development, the adverse effects of IAI on the fetal development are mediated by proinflammatory cytokines to a large extent. [7] In recent years, more literatures have confirmed that IAI can lead to the inflammatory responses, fetal anomaly, dead fetus, fetal dysplasia and so on. [8,9] However, there are few researches on the effects of IAI in different periods of pregnancy on pregnant and fetal rats.…”

Section: Introductionmentioning

confidence: 99%

Effects of intrauterine infection in different periods on the placenta and endometrial blood vessel formation of pregnant mice and the growth and development of fetal rats

Xiao-li¹,

Zhang

Ren

2021

DCC

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Objective: To investigate the effects of intrauterine infection in different periods on the placenta and endometrial blood vessel formation of pregnant rats and the growth and development of fetal rats.Methods: According to the random number table method, 32 pregnant rats were divided into the early infection group, the mid-term infection group, the late infection group and the control group, with 8 rats in each group. On the 3rd, 9th and 15th day of pregnancy, lipopolysaccharide was injected intraperitoneally to construct intrauterine infection models. The pregnant rats in the control group were intraperitoneally injected with the same dose of 0.9% sodium chloride solution. On the 18th day of pregnancy, the inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)], the blood vessel density of placenta and endometrium in the placental tissues of pregnant rats, dead fetus + absorbed fetus, the inflammatory factors IL-6, TNF-α and oxidation reaction indicators [malondialdehyde (MDA) and myeloperoxidase (MPO)] in the fetal rat lung and brain tissues were detected.Results: The changing trend of IL-6 and TNF-α levels in the placental tissues of pregnant rats with intrauterine infection in different periods was: the control group < the late infection group < the mid-term infection group < the early infection group, the differences were statistically significant (p <.05). The changing trend of fetal rat weight, placental weight and placental coefficient in the intrauterine infection groups in different periods was: the control group > the late infection group > the mid-term infection group > the early infection group, the differences were statistically significant (p < .05). The blood vessel density of placenta and endometrium, the mean number of fetuses, brain coefficient and lung coefficient in the late infection group were significantly increased in comparison with the early infection group and the mid-term infection group. The total number and the ratio of dead fetus + absorbed fetus, the levels of IL-6, TNF-α, MDA and MPO in brain and lung tissues were significantly reduced, and the differences were statistically significant (p < .05). The blood vessel density of placenta and endometrium, brain coefficient and lung coefficient of pregnant rats in the mid-term infection group were significantly increased in comparison with the early infection group, and the differences were statistically significant (p < .05). There was no statistically significant difference in the other indicators between the two groups (p > .05).Conclusions: Intrauterine infection in different periods can inhibit placental and endometrial angiogenesis, and affect the survival rate of fetal rats and the growth and development of brain and lung. The reason may be related to the aggravation of fetal inflammatory responses and oxidative stress. The earlier the intrauterine infection occurs, the severer the adverse effects on the fetal rats will be.

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Relationship between cytokine profiles of cord blood and cord S100B levels in preterm infants

Niwa

Imai

Kotani

et al. 2019

Early Human Development

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The impact of intrauterine infection on fetal brain damage assessed by S100B protein concentrations in umbilical cord arteries

Abstract: Higher concentration of S100B protein in Group I suggests that intrauterine infection itself has a serious risk factor on fetal brain damage.

Cited by 3 publications

References 17 publications

Association of miR-182 expression in amniotic fluid with intrauterine infection and brain injury in premature infants

Association of miR-182 expression in amniotic fluid with intrauterine infection and brain injury in premature infants

Effects of intrauterine infection in different periods on the placenta and endometrial blood vessel formation of pregnant mice and the growth and development of fetal rats

Relationship between cytokine profiles of cord blood and cord S100B levels in preterm infants

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