The Impact of Lidocaine on Flap Survival Following Reperfusion Injury

Eskitaşçıoğlu, Teoman; Karaci, Selman; Canöz, Özlem; Kilic, Eser; Günay, Galip K.

doi:10.1016/j.jss.2009.05.046

Cited by 21 publications

(16 citation statements)

References 25 publications

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“…Testicular T/D‐induced I/R results in testicular damage (Mogilner et al ., ). Tissue is damaged by various mechanisms during reperfusion in an ischaemia/reperfusion period (Eskitascioglu et al ., ). Levels of mCa 2+ increase via mCa 2+ uniporter channels that increase intracellular Ca 2+ levels.…”

Section: Discussionmentioning

confidence: 97%

“…Thus, many groups have focused on the role of Ca 2+ channel blockers in the prevention of I/R injury in several organs (Trocha & Szelag, ; Vercesi et al ., ) as well as cellular Ca 2+ accumulation, cytochrome c release and cell death after I/R injury in organs. Previous studies have reported that Ca 2+ /Na + channel blockers, verapamil and lidocaine, respectively, ameliorate the effect of I/R (Uchida et al ., ; Eskitascioglu et al ., ; Popp et al ., ). The mechanism of verapamil may be related to a blockade of voltage‐dependent Ca 2+ channels (Fleckenstein, ).…”

Section: Discussionmentioning

confidence: 99%

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Effects of amlodipine on ischaemia/reperfusion injury in the rat testis

et al. 2015

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The aim of this study was to examine the effects of amlodipine (AML) in rat testicular torsion/detorsion damage. In this study, rats were divided into eight groups: (i) sham; (ii) testicular ischaemia, 2 h of ischaemia; (iii) testicular ischaemia/reperfusion (I/R), 2 h of ischaemia followed by 2 h of reperfusion; (iv) ischaemia + AML (5 mg kg(-1)) administered 30 min before ischaemia; (v) ischaemia + AML (10 mg kg(-1)) administered 30 min before ischaemia; (vi) and (vii) I/R + AML (5 mg kg(-1)) and I/R + AML (10 mg kg(-1)) administered 1.5 h after the induction of ischaemia, respectively, and at the end of a 2-h ischaemia period and a 2-h reperfusion period applied; and (viii) sham + AML (10 mg kg(-1)). Significant decreases in levels of superoxide dismutase and glutathione were observed in ischaemia and reperfusion groups when compared with healthy controls. These antioxidant levels increased in AML groups while malondialdehyde levels significantly decreased. While increases in tumour necrosis factor-alpha and transforming growth factor-beta levels were found in the torsion and detorsion groups, significant decreases in the levels of these inflammatory cytokines were observed in the treatment groups. These results demonstrate that AML significantly produced protective effects on testis tissue damage that occurs in the torsion/detorsion model via biochemical, histopathological and molecular pathways.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Effects of amlodipine on ischaemia/reperfusion injury in the rat testis

et al. 2015

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“…I/R injury is a complex inflammatory process and is considered to be the main pathogenic factor associated with random flap survival [3]. Oxygen-delivered free radicals contribute greatly to I/R injury [23].…”

Section: Discussionmentioning

confidence: 99%

“…The lengthewidth ratio cannot be >2:1, greatly limiting therapy applications of random skin flaps. Previous studies [3,4] have confirmed that ischemiaereperfusion (I/R) injury and neutrophil infiltration result in flap necrosis. Various kinds of agents have been tested to prevent skin flap ischemia, such as resveratrol [5], heparin [6], and vascular endothelial growth factor (VEGF) [7].…”

Section: Introductionmentioning

confidence: 92%

Beneficial effects of Xuebijing injection on random skin flap survival in rats

Cao

Lin

Cai

et al. 2015

Journal of Surgical Research

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“…During I/R, damage occurs due to accumulation of intercellular Ca 2+ and free radicals (48). The Ca 2+ /Na + channel blockers verapamil, lidocaine and nifedipine ameliorate the effect of I/R (49)(50)(51)(52). Recently, it was demonstrated that amlodipine decreases free radical levels and increases the levels antioxidants including SOD and GSH (14).…”

Section: Calcium Channel Blockersmentioning

confidence: 99%

Medical perspective in testicular ischemia-reperfusion injury

Arena

Iacona

Antonuccio

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Testicular torsion or torsion of the spermatic cord is one of the most serious urological conditions. It causes testicular injury, which potentially leads to male subfertility. The turning of the spermatic cord and spermatic structures around themselves results in biochemical and histological changes; however, following testicular detorsion, tissues undergo reperfusion that causes more severe damage than that induced by ischemia. Since the primary causes of testicular damage are reactive oxygen species production, an increase in intra-mitochondrial calcium concentration and an increased rate of cellular apoptosis, different medications may potentially be effective. It seems that several medications, experimentally and sometimes clinically, serve an adjuvant role in the cellular damage that occurs following ischemia-reperfusion. Antioxidants, calcium channel blockers, phytotherapeutical medicinals, anaesthetics, hormones and platelet inhibitors may potentially create a solid basis for an adjuvant restoring therapy and ameliorate testicular function following torsion. The current study aimed to review the relevant literature and discuss the actions of a number of molecules that may protect the testes during ischemia/reperfusion injury.

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The Impact of Lidocaine on Flap Survival Following Reperfusion Injury

Cited by 21 publications

References 25 publications

Effects of amlodipine on ischaemia/reperfusion injury in the rat testis

Effects of amlodipine on ischaemia/reperfusion injury in the rat testis

Beneficial effects of Xuebijing injection on random skin flap survival in rats

Medical perspective in testicular ischemia-reperfusion injury

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