The Impact of Microbiota on the Pathogenesis of Amyotrophic Lateral Sclerosis and the Possible Benefits of Polyphenols. An Overview

Abstract

The relationship between gut microbiota and neurodegenerative diseases is becoming clearer. Among said diseases amyotrophic lateral sclerosis (ALS) stands out due to its severity and, as with other chronic pathologies that cause neurodegeneration, gut microbiota could play a fundamental role in its pathogenesis. Therefore, polyphenols could be a therapeutic alternative due to their anti-inflammatory action and probiotic effect. Thus, the objective of our narrative review was to identify those bacteria that could have connection with the mentioned disease (ALS) and to analyze the benefits produced by administering polyphenols. Therefore, an extensive search was carried out selecting the most relevant articles published between 2005 and 2020 on the PubMed and EBSCO database on research carried out on cell, animal and human models of the disease. Thereby, after selecting, analyzing and debating the main articles on this topic, the bacteria related to the pathogenesis of ALS have been identified, among which we can positively highlight the presence mainly of Akkermansia muciniphila, but also Lactobacillus spp., Bifidobacterium spp. or Butyrivibrio fibrisolvens. Nevertheless, the presence of Escherichia coli or Ruminococcus torques stand out negatively for the disease. In addition, most of these bacteria are associated with molecular changes also linked to the pathogenesis of ALS. However, once the main polyphenols related to improvements in any of these three ALS models were assessed, many of them show positive results that could improve the prognosis of the disease. Nonetheless, epigallocatechin gallate (EGCG), curcumin and resveratrol are the polyphenols considered to show the most promising results as a therapeutic alternative for ALS through changes in microbiota.

Convergent pathways of the gut microbiota–brain axis and neurodegenerative disorders

“…Mediated by the gut microbiota, polyphenols were already shown to effectively attenuate AD Aβoligomerization [ 170 ] and the gut microbiota has been hypothesized as one of the potential contributions for resveratrol in mediating neuroprotection and promoting cognition. While the impact of the gut microbiota on ALS and the potential benefits of polyphenols seem promising [ 171 ], so far, no study has directly investigated them.…”

Organ on a Chip: A Novel in vitro Biomimetic Strategy in Amyotrophic Lateral Sclerosis (ALS) Modeling

“…In contrast, the existence of some bacteria such as Akkermansia muciniphila can have beneficial effects on ALS patients. (19,20) ALS, Amyotrophic lateral sclerosis; BMAA, Beta methyl-amino-alanine; BMI, Body mass index; Chl-a, Chlorophyll-a; EVs, Enterovirus; SD, Secchi depth; TN, Total nitrogen.…”

The Microbiota-Gut-Brain Axis as a Key to Neuropsychiatric Disorders: A Mini Review

“…In some studies, it was observed that transgenic mice, even at the presymptomatic stage, show evidence of dysbiosis. Among a few types of different bacteria which can be related to the pathogenesis of ALS Akkermansia muciniphila should be highlighted [54,55].…”