The Impact of Microinvasion on Axillary Node Metastases and Survival in Patients With Intraductal Breast Cancer

Wong, Jan H.; Kopald, Kelly H.; Morton, Donald L.

doi:10.1001/archsurg.1990.01410220082011

Cited by 103 publications

(60 citation statements)

References 22 publications

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“…Since LCIS is neither a ''precursor'' nor ''premalignant,'' the current prevailing view is that it does not progress to ''microinvasive'' or invasive lobular carcinoma. In our experience as well as that of others, rare cases of lobular carcinoma in situ with microinvasion were noted or reported [5,6]. In this report we describe six case of LCIS encountered between January 1996 and December 1996 bearing the feature of microinvasion.…”

Section: Introductionsupporting

confidence: 53%

Lobular carcinoma in situ with microinvasion

et al. 1998

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Section: Introductionsupporting

confidence: 53%

Lobular carcinoma in situ with microinvasion

et al. 1998

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“…Another subgroup with low potential of axillary metastases is microinvasive carcinoma. Most of the papers 19,20 show a 5% incidence of axillary metastases, even though Schuh et al 21 and Kinne et al 22 found axillary damage rates between 20 and 10%, respectively. The different definitions of what a microinvasive or invasive tumor is would result in this frequency variation of the axillary metastasis process.…”

Section: Discussionmentioning

confidence: 99%

Frequency and factors associated with injury to the axillary vein in women that underwent axillary lymphadenectomy during breast cancer surgical treatment

Corrêa¹,

Hubie²,

Ribeiro³

et al. 2017

Rev. Bras. Mastol. (Impr.)

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Objetivo: Avaliar quais variáveis se apresentam como fatores de risco associados à lesão da veia axilar durante a linfadenectomia no tratamento cirúrgico de pacientes portadoras de câncer de mama. Métodos: Estudo retrospectivo realizado por meio da análise de prontuário eletrônico de 1.007 pacientes submetidas a esvaziamento axilar no Hospital Erasto Gaertner, no período de janeiro de 2010 a dezembro de 2014. Foram avaliados, por meio de um questionário padrão, os seguintes possíveis fatores de risco: idade, índice de massa corpórea (IMC), presença de metástase axilar palpável no exame clínico, linfonodo sentinela pré-linfadenectomia, presença de metástase axilar no transoperatório, tamanho da metástase e se estava aderida aos vasos axilares, presença de invasão do músculo peitoral, ressecção do músculo peitoral menor, incisão axilar separada da incisão mamária, radioterapia prévia, quimioterapia neoadjuvante e estadiamento pré e pós-operatório. Para cada paciente que apresentou lesão de veia axilar foi realizado pareamento com dois controles homogêneos (idade, IMC, estadiamento pré-operatório, proposta cirúrgica e tratamento neoadjuvante). Resultados: Treze pacientes apresentaram lesão da veia axilar. Na avaliação transoperatória, em sua grande maioria, RESUMO ABSTRACTObjective: To evaluate which variables are considered risk factors associated with injury to the axillary vein during lymphadenectomy in the surgical treatment of breast cancer patients. Methods: Retrospective study performed through the electronic record analysis of 1,007 patients who underwent axillary lymph node dissection at Hospital Erasto Gaertner, from January 2010 to December 2014. We assessed the following risk factors using a standard questionnaire: age, body mass index (BMI), presence of palpable axillary metastasis in the clinical examination, sentinel lymph node pre-lymphadenectomy, presence of axillary metastasis in the perioperative period, size of metastasis and if it was adhered to axillary vessels, presence of pectoralis muscle invasion, resection of the pectoralis minor muscle, axillary incision separated from breast incision, prior radiotherapy, neoadjuvant chemotherapy, and pre and postoperative staging. For each patient who presented injury to the axillary vein, we paired them with two homogeneous controls (age, BMI, preoperative staging, surgical proposal, and neoadjuvant treatment). Results: Thirteen patients had injury to the axillary vein. In the perioperative evaluation, in most of them, the axilla was positive in the injury group (10 cases = 76.9%) and control group (12 cases = 46.1%), and it was adhered to axillary vessels in 10 cases in the injury group (76.9%) and 7 in the control group (26.9%). Conclusion: In this study, the presence of axillary metastasis in the perioperative evaluation, as well as that adhered to the axillary vessels, is associated with an increased risk of injury to the axillary vein during lymphadenectomy.

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“…Tal como acontece com câncer invasivo e CDIS puro, a CCM seguida de RT para toda a mama é a abordagem mais comum com taxas de sobrevida equivalentes. O risco de recorrência após CCM para a doença microinvasora aumenta com margens cirúrgicas positivas, CDIS extenso e características histopatológicas desfavoráveis, como subtipo comedo e alto grau nuclear [11][12][13][14] . A introdução da biópsia de linfonodo sentinela (BLS) permitiu um novo pensamento acerca da investigação do status axilar nos casos de microinvasão, pois este procedimento tem menor morbidade e permite um estadiamento mais preciso usando cortes seriados e estudo imuno-histoquímico do linfonodo sentinela.…”

Section: Discussionunclassified

Carcinoma microinvasor de mama: resultados em longo prazo

Gioia¹,

Marinho²,

Murteira³

et al. 2016

Rev. Bras. Mastol. (Impr.)

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A aparência radiológica das calcificações encontrada nas lesões de CMM (68%) mimetizou os achados vistos no CDIS. Axila positiva foi encontrada em 9,6% dos casos. Após um seguimento médio de oito anos, foi observado um caso de recidiva loco regional e quatro casos de recidiva à distancia. A sobrevida global foi de 95,6% e a sobrevida livre de doença, de 96,5%. Conclusão: Apesar do potencial de metástase nodal no nosso estudo, o CMM possui um bom prognóstico e é associado ao baixo risco de metástase para linfonodos axilares. O conhecimento da clínica e da radiologia de lesões com CDIS poderá alertar ao médico sobre a possibilidade de microinvasão e orientação do manejo adequado para cada paciente. ABSTRACT Objective: Microinvasive breast carcinoma (MBC) is an uncommon breast carcinoma subtype although an increase of screening mammography in recent decades has resulted in a higher incidence of ductal carcinoma in situ (DCIS), as well as invasive carcinomas at early stages. The objective of this research study was to review 115 cases of MBC from Brazilian National Cancer

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The Impact of Microinvasion on Axillary Node Metastases and Survival in Patients With Intraductal Breast Cancer

Cited by 103 publications

References 22 publications

Lobular carcinoma in situ with microinvasion

Lobular carcinoma in situ with microinvasion

Frequency and factors associated with injury to the axillary vein in women that underwent axillary lymphadenectomy during breast cancer surgical treatment

Carcinoma microinvasor de mama: resultados em longo prazo

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