The impact of micronized purified flavonoid fraction on the treatment of acute haemorrhoidal episodes

Jiang, Zhu-Ming; Cao, Ji

doi:10.1185/030079906x104803

Cited by 37 publications

(57 citation statements)

References 8 publications

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“…Drei Th eorien werden in der Literatur kontroversiell diskutiert [8,9] [23,24]. Eine Reihe von prospektiv-randomisierten Studien haben einen positiven Eff ekt für Diosmin hinsichtlich der Studienendpunkte Schmerz, Blutung und Pruritus ergeben [25][26][27][28][29][30].…”

Section: Pathophysiologie Und Symptomatikunclassified

Konsensusbericht Hämorrhoidalleiden

Aigner

Conrad²,

Haunold

et al. 2012

Wien Klin Wochenschr

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Haemorrhoidal disease belongs to the most common benign disorders in the lower gastrointestinal tract. Treatment options comprise conservative as well as surgical therapy still being applied arbitrarily in accordance with the surgeon's expertise. The aim of this consensus statement was therefore to assess a stage-dependent approach for treatment of haemorrhoidal disease to derive evidence-based recommendations for clinical routine. The most common methods are discussed with respect of haemorrhoidal disease in extraordinary conditions like pregnancy or inflammatory bowel disease and recurrent haemorrhoids. Tailored haemorrhoidectomy is preferable for individualized treatment with regard to the shortcomings of the traditional Goligher classification in solitary or circular haemorrhoidal prolapses.

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Section: Pathophysiologie Und Symptomatikunclassified

Konsensusbericht Hämorrhoidalleiden

Aigner

Conrad²,

Haunold

et al. 2012

Wien Klin Wochenschr

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“…Tribenoside or bromelain are effective for inflammatory edema; 59) local anesthetic agents are effective for pain; and bismuth-based agents are effective for bleeding. There are some reports from abroad indicating that pain, swelling, and bleeding can be addressed with flavonoids 60,61) .…”

Section: ) Drug Treatmentmentioning

confidence: 99%

Japanese Practice Guidelines for Anal Disorders I. Hemorrhoids

Yamana

2017

J Anus Rectum Colon

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The pathogenesis of hemorrhoids is a weakening of the anal cushion and spasm of the internal sphincter. Bowel habits and lifestyles can be risk factors for hemorrhoids. The prevalence of hemorrhoids can encompass 4 to 55% of the population. Symptoms include bleeding, pain, prolapsing, swelling, itching, and mucus soiling. The diagnosis of hemorrhoids requires taking a thorough history and conducting an anorectal examination. Goligher's classification, which indicates the degree of prolapsing with internal hemorrhoids, is useful for choosing treatment. Drug therapy for hemorrhoids is typically utilized for bleeding, pain, and swelling. Ligation and excision (LE) is considered for Grade III and IV internal and external hemorrhoids. Rubber band ligation is used to treat up to Grade III internal hemorrhoids. Phenol almond oil is effective for internal hemorrhoids up to Grade III, while aluminum potassium sulfate and tannic acid have shown efficacy in treating prolapsing in internal hemorrhoids at Grades II, III, and IV. Procedure for prolapse and hemorrhoids (PPH) is surgically effective for Grade III internal hemorrhoids; however, the long-term prognosis is not favorable, with high recurrence rates. Separating ligation is effective surgical treatment for internal/external hemorrhoids Grade III and Grade IV. The basic approach to thrombosed external hemorrhoids and incarcerated hemorrhoids is conservative treatment; however, in some acute or severe cases, surgical resection is considered. Comparing the different instruments used for hemorrhoid surgery, all reduce operating time, blood loss, post-operative pain, and length of time until the return to normal activity. They do, of course, increase the cost of the procedure.

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“…There is no evidence that treatment with Daflon 500 mg modifies blood pressure or laboratory parameters [79,80,[88][89][90]95]. Systolic or diastolic blood pressure and laboratory values did not change during treatment with two tablets of Daflon 500 mg daily for 1 year in a clinical trial (n=215) that monitored these parameters every 4 months [80].…”

Section: Daflon 500 Mg Tolerabilitymentioning

confidence: 99%

Essentials of Daflon 500 mg: From Early Valve Protection to Long-Term Benefits in the Management of Chronic Venous Disease

Pascarella¹

2007

CPD

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Primary chronic venous disease (CVD) is a common condition that can cause significant morbidity for sufferers and considerable burden on health care systems. Prolonged venous hypertension in conjunction with valvular incompetence and venous reflux is responsible for the diverse clinical manifestations of CVD and links all theories regarding CVD pathogenesis.Recent data suggest that valve damage may be acquired rather than congenital, and caused by inflammatory factors, notably leukocyte activation triggered by venous hypertension. Valve incompetence leads to reflux, reinforcing venous pressure elevation and initiating a vicious circle of disease progression. Loss of venous tone and lymphatic overload also play a role. Valve failure in superficial and perforating veins leads to elevated pressure in the veins and venules of the skin and subcutaneous tissue, resulting in skin hyperpigmentation, induration and ultimately ulceration.The inflammatory cascade may be ameliorated by pharmacologic intervention to decrease leukocyte activation and leukocyte endothelial interactions at both macro-and microcirculatory levels. Daflon 500 mg (micronized purified flavonoid fraction) offers great potential for achieving this with demonstrated efficacy in reducing inflammation and thus providing tissue protection at all stages of the disease. Experiments in animal and human models of CVD have shown that Daflon 500 mg modulates leukocyte rolling and adhesion and prevents endothelial damage in both veins and capillaries. Such treatment is useful for first-line management of edema as well as associated symptoms of CVD. A recent meta-analysis has confirmed that venous leg ulcer healing is accelerated by adding Daflon 500 mg to conventional treatment.

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The impact of micronized purified flavonoid fraction on the treatment of acute haemorrhoidal episodes

Cited by 37 publications

References 8 publications

Konsensusbericht Hämorrhoidalleiden

Konsensusbericht Hämorrhoidalleiden

Japanese Practice Guidelines for Anal Disorders I. Hemorrhoids

Essentials of Daflon 500 mg: From Early Valve Protection to Long-Term Benefits in the Management of Chronic Venous Disease

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