The impact of microwave-assisted organic chemistry on drug discovery

Wathey, Bernard; Tierney, Jason; Lidström, Pelle; Westman, Jacob

doi:10.1016/s1359-6446(02)02178-5

Cited by 194 publications

(55 citation statements)

References 35 publications

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“…Microwaves have also shown an advantage when products may decompose under prolonged reaction conditions. The possibilities offered by microwave-assisted reactions are particularly attractive for multi-step synthesis 17 and drug discovery process 18,19 where purification are highly …”

Section: Figurementioning

confidence: 99%

Efficient Niementowski synthesis of novel 1,3,10,12-tetra-substituted-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-ones

Laddha¹,

BHATNAGAR²

2007

Arkivoc

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Novel 1,3,10,3':4,5]pyrimido [6,1-b]quinazolin-8-ones were synthesised by a Niementowski reaction involving condensation of substituted anthranilic acids with a 5,7-disubstituted-3H-pyrido[2,3-d]pyrimidin-4-ones. Microwave irradiation in polyphosphoric acid media was used in order to improve reactions where classical or direct fusion method was limited. The synthesis of title compounds highlights a comparative study of the classical, microwave technique and direct fusion methods.

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Section: Figurementioning

confidence: 99%

Efficient Niementowski synthesis of novel 1,3,10,12-tetra-substituted-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-ones

Laddha¹,

BHATNAGAR²

2007

Arkivoc

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“…Major aim of this integrated technology is to exploit high degree of molecular diversity and high throughput organic synthesis to rapid access greatly expanded drug-like compound collection without tedious or time-consuming processes. 15,16 In recent years, the use of heterogeneous catalysts has received considerable intrest in various disciplines including organic synthesis. Synthetic organic routes followed by using heterogeneous catalysts have advantages over their counterparts in which, used catalyst can be easily recycled.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Catalytic Activity of Ce₁Mg_xZr_1-xO₂(CMZO) Solid Heterogeneous Catalyst for the Synthesis of 5-Arylidine Barbituric acid Derivatives

Rathod¹,

Gambhire²,

Arbad³

et al. 2010

Bulletin of the Korean Chemical Society

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A series of Ce1MgxZr1-xO2 (CMZO) mixed metal oxide with different molar ratio were prepared by simple co-precipitation method. The prepared materials were tested for their catalytic activity performance using Knoevenagel condensation of various aromatic aldehydes with barbituric acid under solvent-free condition in microwave. The best catalytic activity was obtained with CMZO (1:0.6:0.4). The synthesized materials were characterized by using XRD, FT-IR, SEM-EDS techniques.

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“…The advantages of microwave assisted organic synthesis are high speed, increased yield and clear chemistry [18]. Nowadays, microwave assisted organic synthesis has become a new era in the field of synthetic chemisty [20]. Through cyclization reactions, substituted benzimidazole derivatives have been synthesized in a variety of conditions, using solvents, such as dry benzene and toluene, and ring-closing agents, such as polyphosphoric acid (PPA) and p-toluene sulfonic acid [21,22].…”

Section: Introductionmentioning

confidence: 99%

Comparative studies on conventional and microwave-assisted synthesis of a series of 2,4-di and 2,3,4-trisubstituted benzimidazo[1,2-a] pyrimidines and their antimicrobial activities

et al. 2009

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Comparative studies were performed on a series of 2,4-di and 2,3,4-trisubstituted benzimidazo[1,2-a]pyrimidines, which were synthesized with conventional and microwave heating methods. In microwave irradiation method, approximately, 95–97.5% of the reaction time was increased and 1–45% yield increase was obtained. All compounds were able to inhibit the growth of the screened microorganisms in vitro with MIC values between 3.9–250 μg mL−1. The highest activity was expressed by compound IIId (2,4-diphenyl-benzo[4,5]imidazo[1,2-a] pyrimidine), which has the MIC value of 3.9 μg mL−1 and 31.2 μg mL-1 for Penicillium natatum ATCC 24791 and E. faecalis ATCC 29212, respectively.

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The impact of microwave-assisted organic chemistry on drug discovery

Cited by 194 publications

References 35 publications

Efficient Niementowski synthesis of novel 1,3,10,12-tetra-substituted-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-ones

Efficient Niementowski synthesis of novel 1,3,10,12-tetra-substituted-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-ones

Synthesis, Characterization and Catalytic Activity of Ce₁Mg_xZr_1-xO₂(CMZO) Solid Heterogeneous Catalyst for the Synthesis of 5-Arylidine Barbituric acid Derivatives

Comparative studies on conventional and microwave-assisted synthesis of a series of 2,4-di and 2,3,4-trisubstituted benzimidazo[1,2-a] pyrimidines and their antimicrobial activities

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The impact of microwave-assisted organic chemistry on drug discovery

Cited by 194 publications

References 35 publications

Efficient Niementowski synthesis of novel 1,3,10,12-tetra-substituted-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-ones

Efficient Niementowski synthesis of novel 1,3,10,12-tetra-substituted-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-ones

Synthesis, Characterization and Catalytic Activity of Ce1MgxZr1-xO2(CMZO) Solid Heterogeneous Catalyst for the Synthesis of 5-Arylidine Barbituric acid Derivatives

Comparative studies on conventional and microwave-assisted synthesis of a series of 2,4-di and 2,3,4-trisubstituted benzimidazo[1,2-a] pyrimidines and their antimicrobial activities

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Synthesis, Characterization and Catalytic Activity of Ce₁Mg_xZr_1-xO₂(CMZO) Solid Heterogeneous Catalyst for the Synthesis of 5-Arylidine Barbituric acid Derivatives