The impact of murine cytomegalovirus (MCMV) on enclosure populations of house mice (Mus domesticus)

Farroway, L.N.; Singleton, Grant R.; Lawson, Malcolm; Jones, Dean A.

doi:10.1071/wr01066

Cited by 12 publications

(18 citation statements)

References 23 publications

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“…(6) There was no additional mortality due to disease, i.e. α = 0 (Shellam 1994;Farroway et al 2002). (7) The rate of vertical/pseudovertical transmission to offspring is uncertain so we modelled the two extremes of 0% and 100% vertical/pseudovertical transmission.…”

Section: Disease Modelmentioning

confidence: 99%

Predicting the effect of immunocontraceptive recombinant murine cytomegalovirus on population outbreaks of house mice (Mus musculus domesticus) in mallee wheatlands

2005

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Virally vectored immunocontraception using a modified murine cytomegalovirus (MCMV) is being developed for the control of house mice in Australia. In this paper, we develop disease-host models using a combination of laboratory and field data. We then combine these models with a model of a previous mouse population outbreak to explore the likely effectiveness of modified MCMV for controlling mice. Models of homogeneous mixing with and without vertical/pseudovertical transmission provided reasonable fits to field serological data collected during the onset and development of a mouse population outbreak in south-eastern Australia. Both models include the high transmission rate of MCMV suggested by the data. We found no strong support for non-linear contact rates or heterogeneous mixing. When applied to a past outbreak of mice both models gave similar results and suggested that immunocontraceptive MCMV could be effective at reducing agricultural damage to acceptable levels. Successful control was still possible when lags in the development of infertility of up to 10 weeks were added to the model, provided high levels of infertility were achieved. These lags were added because mice can become pregnant just before becoming infertile -the resultant litter would not emerge for 6-7 weeks. Trade-offs between two parameters that could be altered by engineering strains of MCMV -the level of infertility in infected mice and the virus transmission rate -were explored and suggest that a variety of parameter combinations could produce successful control. Our results are encouraging for the future development of virally vectored immunocontraception control of house mice, but future work will need to consider some of the assumptions of these single-strain models.

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Section: Disease Modelmentioning

confidence: 99%

Predicting the effect of immunocontraceptive recombinant murine cytomegalovirus on population outbreaks of house mice (Mus musculus domesticus) in mallee wheatlands

2005

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“…Between the first isolation of the Smith strain of MCMV and 2007, there have been almost 3,000 studies published on various aspects of MCMV biology. However, fewer than 1% of these (including references 4,9,11,12,14,20, and 32) use a virus strain other than Smith or K181. In order to extend the MCMV model to other low-passage isolates of MCMV, we sequenced the viral genomes and mapped the in vivo growth capacity of three low-passage strains of MCMV in susceptible (BALB/c) and resistant (C57BL/6 and CBA) mice.…”

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confidence: 99%

Laboratory Strains of Murine Cytomegalovirus Are Genetically Similar to but Phenotypically Distinct from Wild Strains of Virus

Smith

McWhorter

Masters

et al. 2008

J Virol

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Murine cytomegalovirus (MCMV) is widely used to model human cytomegalovirus (HCMV) infection.However, it is known that serially passaged laboratory strains of HCMV differ significantly from recently isolated clinical strains of HCMV. It is therefore axiomatic that clinical models of HCMV using serially passaged strains of MCMV may not be able to fully represent the complexities of the system they are attempting to model and may not fully represent the complex biology of MCMV. To determine whether genotypic and phenotypic differences also exist between laboratory strains of MCMV and wild derived strains of MCMV, we sequenced the genomes of three low-passage strains of MCMV, plus the laboratory strain, K181. We coupled this genetic characterization to their phenotypic characteristics. In contrast to what is seen with HCMV (and rhesus CMV), there were no major genomic rearrangements in the MCMV genomes. In addition, the genome size was remarkably conserved between MCMV strains with no major insertions or deletions. There was, however, significant sequence variation between strains of MCMV, particularly at the genomic termini. These more subtle genetic differences led to considerable differences in in vivo replication with some strains of MCMV, such as WP15B, replicating preferentially in otherwise-MCMV-resistant C57BL/6 mice. CBA mice were no more resistant to MCMV than C57BL/6 mice and for some MCMV strains appeared to control infection less well than C57BL/6 mice. It is apparent that the previously described host resistance patterns of inbred mice and MCMV are not consistently applicable for all MCMV strains.

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“…The strains are acquired by immunocompetent mice through simultaneous or successive infections (12). A study on enclosure populations of M. m. domesticus has shown that MCMV had minimal or no impact on mouse survival or breeding when individuals were infected with a single strain but that young males infected with two viral strains had a 20% reduction in survival (13). The Mus musculus species group comprises 5 species (Mus musculus, Mus spretus, Mus spicilegus, Mus macedonicus, and Mus cypriacus) (14).…”

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confidence: 99%

Murine Cytomegalovirus Is Not Restricted to the House Mouse Mus musculus domesticus: Prevalence and Genetic Diversity in the European House Mouse Hybrid Zone

Bellocq

Baird

Albrechtová

et al. 2015

J Virol

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Murine cytomegalovirus (MCMV) is a betaherpesvirus of the house mouse, Mus musculus domesticus. It is a common infectious agent of wild mice and a highly studied pathogen of the laboratory mouse. Betaherpesviruses are specific to their hosts, and it is not known if other Mus taxa carry MCMV or if it is restricted to M. m. domesticus. We sampled mice over a 145-km transect of Bavaria-Bohemia crossing a hybrid zone between M. m. domesticus and Mus musculus musculus in order to investigate the occurrence of MCMV in two Mus subspecies and to test the limits of the specificity of the virus for its host. We hypothesized that if the two subspecies carry MCMV and if the virus is highly specific to its host, C ytomegaloviruses (CMVs) are enveloped double-stranded DNA viruses (family Herpesviridae, subfamily Betaherpesvirinae) that have coevolved with their vertebrate hosts. Murine cytomegalovirus 1 (MCMV), also called Murid herpesvirus 1 (MuHV-1), is a betaherpesvirus of the house mouse and one of its most studied pathogens, because it serves as a laboratory model for human cytomegalovirus (HCMV) infection, which can be highly pathogenic for immunocompromised individuals (1). Almost all laboratory research on MCMV uses either the Smith or the K181 strain of the virus (2). The Smith strain was originally isolated from salivary gland tissue of laboratory mice in the United States in 1954 (3), and the K181 strain was selected by repeated passage of the prototype Smith strain in mouse submaxillary glands (2). These strains have been serially passaged in vivo and in vitro-in the case of the Smith virus, for more than 50 years. Apart from the two standard MCMV laboratory strains, several strains have been isolated from wild house mice in Australia, Beacon Island, and Macquarie Island, and their whole genomes have been sequenced (2, 4, 5). These strains are genetically different from strains Smith and K181 (4) and show in vivo replication kinetics different from those of the standard strains (5), suggesting that the patterns of host resistance to MCMV described for inbred mice are not applicable to all MCMV strains (2). All of these strains have been isolated either from a single subspecies of mouse, Mus musculus domesticus, or from lab mice, which are derived mostly from M. m. domesticus stocks (6).Several studies have investigated the occurrence of antibodies

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The impact of murine cytomegalovirus (MCMV) on enclosure populations of house mice (Mus domesticus)

Cited by 12 publications

References 23 publications

Predicting the effect of immunocontraceptive recombinant murine cytomegalovirus on population outbreaks of house mice (Mus musculus domesticus) in mallee wheatlands

Predicting the effect of immunocontraceptive recombinant murine cytomegalovirus on population outbreaks of house mice (Mus musculus domesticus) in mallee wheatlands

Laboratory Strains of Murine Cytomegalovirus Are Genetically Similar to but Phenotypically Distinct from Wild Strains of Virus

Murine Cytomegalovirus Is Not Restricted to the House Mouse Mus musculus domesticus: Prevalence and Genetic Diversity in the European House Mouse Hybrid Zone

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