The Impact of Neoadjuvant Hormonal Therapy on the Outcome of Laparoscopic Radical Prostatectomy: A Matched Pair Analysis

Maldonado-Valadez, Rafael; Teber, Doğu; Erdoğru, Ti̇bet; Safi, Khalid C.; Frede, Thomas; Rassweiler, Jens

doi:10.1016/s0022-5347(06)00260-6

Cited by 15 publications

(13 citation statements)

References 17 publications

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“…Brown et al (2004) described 0% positive surgical margins in Wve patients who received androgen deprivation before LRP compared to 17% in 60 without hormonal treatment. However, Maldonado-Valadez et al (2006) recently did not see any diVerence in the rate of positive surgical margins between 3-month NHT group and direct LRP group (18% vs. 16%, P = 1.000). The study group matched patients according to pathological stage and considered there is minor impact of neoadjuvant hormonal deprivation on positive surgical margins.…”

Section: Discussionmentioning

confidence: 93%

“…Injury to the epigastric vessels, postoperative ileus, hemoperitoneum, acute urinary retentions, anastomotic leakages, anastomotic stricture, hydrocele and urinary tract infections were observed. Brown et al (2004) compared 5 patients who did and 60 who did not receive neoadjuvant hormonal -Valadez et al (2006) evaluated the eVect of 3-month NHT on LRP operative and postoperative parameters through a matched pair analysis. There were no signiWcant diVerences between the neoadjuvant and non-neoadjuvant groups with respect to mean operative time, mean blood loss, transfusion rate, median catheter time, the complication rate and diYcult dissection level.…”

Section: Discussionmentioning

confidence: 99%

“…Few comments can be found in the literature with respect to the impact of NHT on LRP operative parameters. Recently, Maldonado-Valadez et al (2006) evaluated the impact of NHT on the outcome of LRP; however, only the 3-month NHT is determined. In this study, we Wrst comparatively study the impact of 3-versus 8-month NHT on outcome of LRP.…”

Section: Introductionmentioning

confidence: 99%

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Comparative study of the impact of 3- versus 8-month neoadjuvant hormonal therapy on outcome of laparoscopic radical prostatectomy

Wang

et al. 2007

J Cancer Res Clin Oncol

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Comparative study of the impact of 3- versus 8-month neoadjuvant hormonal therapy on outcome of laparoscopic radical prostatectomy

Wang

et al. 2007

J Cancer Res Clin Oncol

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“…However, they had no follow-up data as to whether or not prolonged (8-months) NHT prior to LRP altered BCR rates. Table 3 reviews the impact of NHT prior to LRP on PSM and BCR rate [6,7,16-18]. Brown et al [7] studied the safety and efficacy of LRP after NHT.…”

Section: Discussionmentioning

confidence: 99%

Neoadjuvant hormonal therapy is a feasible option in laparoscopic radical prostatectomy

et al. 2012

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BackgroundFew reports can be found in the literature with respect to the impact of neoadjuvant hormonal therapy (NHT) on operative parameters on laparoscopic radical prostatectomy (LRP) in a large study. The aim of this study was to evaluate the safety and efficacy of NHT prior to LRP for locally confined prostate cancer.MethodsFrom January 2004 to September 2009, 342 patients undergoing LRP were analyzed, specifically comparing 72 patients who received NHT to 270 who did not. All patients were in clinical stage T2 and nerve sparing LRP were not included.ResultsThe mean patient age, preoperative prostate specific antigen (PSA), clinical stage, and biopsy Gleason grade were similar for the NHT and the non-NHT LRP groups. The median blood loss and the median operative time were also similar. There were no differences in the intraoperative complication rate of rectum injury, blood transfusion, and open surgery conversion. The positive surgical margin rate was significantly improved in NHT patients. Moreover, PSA recurrence within two years was significantly less in long-term NHT than in non-NHT patients.ConclusionsLRP was shown as a safe and efficacious procedure in patients who have received NHT. Perioperative morbidity of NHT patients undergoing LRP appears equivalent to non-NHT patients, with lower positive surgical margin, and PSA recurrence rate.

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“…Specifically, inflammation caused by this apoptotic change might make surgical exfoliation of tissues difficult by causing adhesion between the prostate and prostate capsule or prostate capsule and peri-prostatic fascia 35. Regarding the effects of NHT on operative procedures in RRP, Yang, et al36 stated that a mean of 3 months of NHT led to longer surgical times than those required for the RRP-alone group, while Selli and Milesi25 reported that NHT did not cause any adverse surgical events.…”

Section: Discussionmentioning

confidence: 99%

Significance of Neoadjuvant Hormonal Therapy in Radical Retropubic Prostatectomy: A Retrospective Single-Surgeon Study

et al. 2013

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PurposeThe purpose of this study was to evaluate whether neo-adjuvant hormonal therapy (NHT) prior to radical retropubic prostatectomy (RRP) for prostate cancer (PCa) is beneficial in terms of surgical outcomes and for preventing or delaying biochemical recurrence via single-surgeon case series study.Materials and MethodsFifty-three men underwent RRP by a single surgeon. The patients were divided into two groups according to whether or not NHT was performed prior to RRP. The study was analyzed retrospectively. We evaluated clinical parameters, surgical parameters, and biochemical recurrence rate. Group 1 (n=34) was treated with RRP only, while Group 2 (n=19) underwent RRP along with NHT.ResultsThere were no significant differences in clinical, operation-related and pathological factors between the two groups (p>0.05). There was also no significant difference in biochemical recurrence rate between the two groups at the last follow-up, although Group 2 tended to have a lower PCa recurrence rate than Group 1 and the initial prostate-specific antigen (PSA) level was significantly higher in Group 2 than Group 1 (p=0.0496).ConclusionThe present single-surgeon case series study revealed a trend toward a lower rate of PCa recurrence in NHT+RRP treated patients compared to those treated with RRP alone, but this did not reach statistical significance, despite the fact that NHT+RRP patients exhibited higher serum PSA levels preoperatively. Prospective studies with a longer duration of observation and a greater number of patients would be helpful in evaluating NHT more definitively.

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The Impact of Neoadjuvant Hormonal Therapy on the Outcome of Laparoscopic Radical Prostatectomy: A Matched Pair Analysis

Cited by 15 publications

References 17 publications

Comparative study of the impact of 3- versus 8-month neoadjuvant hormonal therapy on outcome of laparoscopic radical prostatectomy

Comparative study of the impact of 3- versus 8-month neoadjuvant hormonal therapy on outcome of laparoscopic radical prostatectomy

Neoadjuvant hormonal therapy is a feasible option in laparoscopic radical prostatectomy

Significance of Neoadjuvant Hormonal Therapy in Radical Retropubic Prostatectomy: A Retrospective Single-Surgeon Study

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