The impact of nodal status in major salivary gland carcinoma: A multicenter experience and proposal of a novel N-classification

Lombardi, Davide; Tomasoni, Michele; Paderno, Alberto; Mattavelli, Davide; Ferrari, Marco; Battocchio, Simonetta; Missale, Francesco; Mazzola, Francesco; Peretti, Giorgio; Mocellin, Davide; Borsetto, Daniele; Fussey, Jonathan; Nankivell, Paul; Skalidi, Nikoleta; Bussi, Mario; Giordano, Leone; Galli, Andrea; Arrigoni, Gianluigi; Raffetti, Elena; Pracy, Paul; Poorten, Vincent Vander; Nicolai, Piero

doi:10.1016/j.oraloncology.2020.105076

Cited by 30 publications

(48 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The function of the TNM staging system is not only to describe tumor size, regional lymph nodes, and distant metastasis but staging classification should also reflect the prognosis of individual patients. The N classification describing the neck nodal involvement in parotid cancer is a strong predictor for overall survival (OS) of patients in univariate analyses, but the results in multivariate analyses are controversial [ 1 , 2 , 3 , 4 , 5 ]. Hence, it is not clear if the N classification in parotid cancer is an independent predictor for OS.…”

Section: Introductionmentioning

confidence: 99%

“…LODDS has been demonstrated to be a prognostic classification superior to others such as pN and LNR [ 8 , 9 ], but has not yet been tested in parotid cancer. Furthermore, the current TNM classification does not consider the involvement of intraparotid lymph nodes (PAR) [ 5 ]. Intraparotid lymph nodes can be the only involved lymph node station in a high proportion of patients with parotid cancer, i.e., these patients are classified as N0 [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Intraparotid lymph nodes can be the only involved lymph node station in a high proportion of patients with parotid cancer, i.e., these patients are classified as N0 [ 10 , 11 ]. Intraparotid metastasis (PAR+) seems to be an independent prognosticator for worse overall survival in parotid cancer [ 5 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…As is the case for many other types of head and neck cancer, there is a lack of detailed population-based studies on parotid cancer regarding the role of lymph node metastasis. Most knowledge results from larger monocentric series and retrospective studies and, therefore, has methodological limitations [ 1 , 5 , 6 , 7 ]. Clinical cancer registries allow one to explore the oncological outcome from a population-based perspective but do not allow to evaluate lymph node assessment and locoregional metastasis in detail [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Role of Intraparotid and Neck Lymph Node Metastasis in Primary Parotid Cancer Surgery: A Population-Based Analysis

Kouka

Koehler

Büntzel

et al. 2022

Cancers

View full text Add to dashboard Cite

This population-based study investigated the prognostic role of intraparotid (PAR) and cervical lymph node (LN) metastasis on overall survival (OS) of primary parotid cancer. All 345 patients (median age: 66 years; 43% female, 49% N+, 31% stage IV) of the Thuringian cancer registries with parotid cancer from 1996 to 2016 were included. OS was assessed in relation to the total number of removed PAR and cervical LN, number of positive intraparotid (PAR+), positive cervical LN, LN ratio, log odds of positive LN (LODDS), as well as including the PAR as LODDS-PAR. PAR was assessed in 42% of the patients (22% of these PAR+). T and N classification were not independent predictors of OS. When combining T with LODDS instead of N, higher T (T3/T4) became a prognosticator (hazard ratio (HR) = 2.588; CI = 1.329–5.040; p = 0.005) but not LODDS (p > 0.05). When combining T classification with LODDS-PAR, both higher T classification (HR = 2.256; CI = 1.288–3.950; p = 0.004) and the alternative classification with LODDS-PAR (≥median −1.11; HR 2.078; CI = 1.155–3.739; p = 0.015) became independent predictors of worse OS. LODDS-PAR was the only independent prognosticator out of the LN assessment for primary parotid cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Role of Intraparotid and Neck Lymph Node Metastasis in Primary Parotid Cancer Surgery: A Population-Based Analysis

Kouka

Koehler

Büntzel

et al. 2022

Cancers

View full text Add to dashboard Cite

show abstract

“…Still, these systems have limitations: only tumor size, lymph nodes, and distant metastasis were considered. Moreover, MSGC patients classified as in the same stage may have completely different survival outcomes (7). The nomogram is an effective and convenient tool based on a statistical model for quantitative prediction of clinical events using multiple selected prognostic factors.…”

Section: Introductionmentioning

confidence: 99%

Nomograms-based prediction of overall and cancer-specific survivals for patients diagnosed with major salivary gland carcinoma

Guo¹,

Wang²,

Liu³

et al. 2021

Ann Transl Med

View full text Add to dashboard Cite

Background: Major salivary glands carcinoma (MSGC) is a relatively rare cancer with diverse histological types and biological behavior. The treatment planning and prognosis prediction are challenging for clinicians. The aim of the current study was to establish a reliable and effective nomogram to predict the overall survival (OS) and cancer-specific survival (CSS) for MSGC patients.Methods: Patients pathologically diagnosed with MSGC were recruited from Surveillance, Epidemiology, and End Results (SEER) database and randomly divided into training and validation groups (7:3 ratio).Univariate, multivariate Cox proportional hazard models, and least absolute shrinkage and selection operator (LASSO) regression were adopted for the selection of risk factors. Nomograms were developed using R software. The model performance was evaluated by drawing receiver operating characteristic (ROC), overtime C-index curves, and calibration curves. Harrell C-index, areas under the curves (AUC), and Brier score were also calculated. The decision curve analysis (DCA) was conducted to measure the net clinical benefit.Results: A total of 11,362 patients were identified and divided into training (n=7,953) and validation (n=3,409) dataset. Sex, age, race, marital status, site, differentiation grade, American Joint Committee on Cancer (AJCC) stage, T/N/M stage, tumor size, surgery, and histological type were incorporated into the Cox hazard model for OS prediction after variable selection, while all predictors, except for marital status and site, were selected for CSS prediction. For 5-year prediction, the AUC of the nomogram for OS and CSS was 83.5 and 82.7 in the training and validation dataset, respectively. The C-index was 0.787 for OS and 0.798 for CSS in the validation group. The Brier score was 0.0153 and 0.0130 for OS and CSS, respectively. The calibration curves showed that the nomogram had well prediction accuracy. From the perspective of DCA, a nomogram was superior to the AJCC stage and TNM stage in net benefit. In general, the performance of the nomogram was consistently better compared to the AJCC stage and TNM stage across all settings.Conclusions: The performance of the novel nomogram for predicting OS and CSS of MSGC patients was further verified, revealing that it could be used as a valuable tool in assisting clinical decision-making.

show abstract

Elevated preradiotherapy serum lactate dehydrogenase predicts distant metastasis for lymphoepithelial carcinoma of major salivary gland following postoperative radiotherapy

et al. 2022

View full text Add to dashboard Cite

Background To evaluate the predicting factors associated with distant metastasis (DM) for lymphoepithelial carcinoma of salivary gland (LECSG) following postoperative radiotherapy (PORT). Methods We retrospectively collected 160 eligible patients from two cancer institutions. The DM rate was evaluated using competing risk method. Results The median follow‐up time was 65.6 months. Elevated preradiotherapy serum LDH (ratio >0.5) (p = 0.006) and N classification (N2‐3) (p = 0.001) were independently associated with DM for the LECSG. After the risk stratification, the high‐risk subgroup was defined as the patients presented higher risk score (score >0), whereas 5‐year cumulative incidence of DM in the high‐ and low‐risk group was 30.9% and 6.0%, respectively (p < 0.001). Moreover, a significantly worse overall survival (OS) was observed in the high‐risk patients compared with the low‐risk subgroup (5‐year OS: 83.9% vs. 97.8%, p = 0.006). Conclusion Elevated preradiotherapy serum LDH could serve as a predictive factor for DM in the LECSG following PORT.

show abstract

The impact of nodal status in major salivary gland carcinoma: A multicenter experience and proposal of a novel N-classification

Cited by 30 publications

References 38 publications

Role of Intraparotid and Neck Lymph Node Metastasis in Primary Parotid Cancer Surgery: A Population-Based Analysis

Role of Intraparotid and Neck Lymph Node Metastasis in Primary Parotid Cancer Surgery: A Population-Based Analysis

Nomograms-based prediction of overall and cancer-specific survivals for patients diagnosed with major salivary gland carcinoma

Elevated preradiotherapy serum lactate dehydrogenase predicts distant metastasis for lymphoepithelial carcinoma of major salivary gland following postoperative radiotherapy

Contact Info

Product

Resources

About