Non-communicable diseases have become the leading cause of death worldwide, the origin of which remains unclear. At the same time, in the methodology of hygienic diagnostics and socio-hygienic monitoring, the search for good indicators testifying to the influence of environmental factors on human health is of considerable difficulty. 85-90% of management errors are recognized due to the unreasonable choice of these indicators. The continued growth of non-infectious morbidity in the Russian population indicates the inefficiency of the existing system of socio-hygienic (epidemiological) monitoring and, in general, the state of hygiene as human health science. To obtain reliable monitoring data, it is necessary to introduce a systematic homeostatic indicator that reflects changes in human health, regardless of the nature and origin of external factors, including vital and social factors. In this regard, the goals of this review were to analyze the systemic homeostatic action of the body’s associated water phase and the mechanisms of its electronic exchange interaction with the environment in a relationship that reflects the root causes of metabolic disorders in cellular structures and the subsequent occurrence of chronic non-infectious human diseases. According to quantum notions, an organism is a macroscopic quantum system, each organ and each cell of which is in electronic interaction with each other and with similar structures in the environment. It is precise because of non local connections that health and diseases are significantly dependent on the electrophysical state of the environment. A systemic indicator that reflects the effectiveness of electronic metabolic processes and human health is the proportion of the associated water phase in the body and the associated intensity of electromagnetic emission in the low-frequency and high-frequency spectral regions. In pathological conditions of organs (disease), adaptation is disrupted, which from a physical perspective is regarded as a “gap” in quantum correlation with external sources of electrons. During this process, a sharp decrease in the proportion of the associated water phase occurs, accompanied by the release of excess heat and metabolic shifts. Electron-deficient environmental conditions require the early introduction of measures to counteract dangerous trends in the nation health and the social and hygienic monitoring methodological aspects revision, which can have a significant impact on the “water factor,” through which realized one of the main ways of electron-deficient states the body compensation is implemented.