Non-communicable diseases have become the leading cause of death worldwide, the origin of which remains unclear. At the same time, in the methodology of hygienic diagnostics and socio-hygienic monitoring, the search for good indicators testifying to the influence of environmental factors on human health is of considerable difficulty. 85-90% of management errors are recognized due to the unreasonable choice of these indicators. The continued growth of non-infectious morbidity in the Russian population indicates the inefficiency of the existing system of socio-hygienic (epidemiological) monitoring and, in general, the state of hygiene as human health science. To obtain reliable monitoring data, it is necessary to introduce a systematic homeostatic indicator that reflects changes in human health, regardless of the nature and origin of external factors, including vital and social factors. In this regard, the goals of this review were to analyze the systemic homeostatic action of the body’s associated water phase and the mechanisms of its electronic exchange interaction with the environment in a relationship that reflects the root causes of metabolic disorders in cellular structures and the subsequent occurrence of chronic non-infectious human diseases. According to quantum notions, an organism is a macroscopic quantum system, each organ and each cell of which is in electronic interaction with each other and with similar structures in the environment. It is precise because of non local connections that health and diseases are significantly dependent on the electrophysical state of the environment. A systemic indicator that reflects the effectiveness of electronic metabolic processes and human health is the proportion of the associated water phase in the body and the associated intensity of electromagnetic emission in the low-frequency and high-frequency spectral regions. In pathological conditions of organs (disease), adaptation is disrupted, which from a physical perspective is regarded as a “gap” in quantum correlation with external sources of electrons. During this process, a sharp decrease in the proportion of the associated water phase occurs, accompanied by the release of excess heat and metabolic shifts. Electron-deficient environmental conditions require the early introduction of measures to counteract dangerous trends in the nation health and the social and hygienic monitoring methodological aspects revision, which can have a significant impact on the “water factor,” through which realized one of the main ways of electron-deficient states the body compensation is implemented.

Introduction. This work is devoted to the study of the effect of peroxide anion radicals in submicromol concentrations and the structural organization of the associated water phase in drinking waters, activated by physical methods on the viability of a number of microorganisms in the human gastrointestinal tract. Materials and methods. Studies were carried out using standard methods of microbiological analysis of drinking water on microorganisms of Escherichia coli 1257, Pseudomonas aeruginosa, Salmonella enteritidis 5765, Enterococcus faecalis ATCC 29212, Klebsiela pneumoniae subsp. pneumoniae ATCC 700603, Citrobacter freundii 101/57. Evaluation of changes in the physical parameters of water before and after treatment with the studied technologies was carried out using electrophysical and physical-chemical parameters (hydrogen index, redox potential, content of peroxide anion radical); structural and energy indicators (by the share of the associated water phase and the density of its distribution by energy levels). Results. The data obtained indicate the strongest stabilizing effect on the viability of microorganisms implementing ATP-phase energy metabolism to be µexerted by associates of peroxide anion radicals controlling metabolic processes and providing an extra-substrate channel for maintaining the energy function of microorganisms. We assume that catalytically active waters have a systemic regulatory effect, ensuring the maintenance of homeostasis of microorganisms. Similar regulation is also possible in the intestinal microbiota of the body to maintain or suppress the activity of competing microorganisms when a person uses biocatalytically active (in the range of concentrations of peroxide anion radicals in drinking water from 0.1 to 40 drinking water µg/L) drinking water. We assume that this will solve a number of issues related to the etiology and pathophysiology of a number of gastroenterological diseases caused by changes in the electrophysical state of the internal environment of the gastrointestinal tract, promoting the emergence and development of a competing, adapted to an environment with low electron-donor capacity, bacterial microbiota. Limitations. The data obtained as a result of the experiment on biota similar to the human intestinal microbiota are of scientific interest and research involving warm-blooded animals is necessary to continue work in this direction. Conclusion. Physically treated waters affect the growth or inhibition of intestinal biota colonies, which may be associated with the controlling role of peroxide anion radicals on intracellular metabolic processes in microorganisms

Introduction. The work is devoted to the study of associated water phase magnetic state influence, represented by amorphous ice with a modified ratio of isomers in the increasing of para-water proportion, and non-local water activation based on the technology of non-local quantum water conjugation with the production activating process, on the vital hydrobionts Daphnia magna signs. Material and methods. The studies were carried out using non-locally activated drinking water “Si” and a para-water concentrate prepared in hypomagnetic conditions at a residual magnetic flux density not more than 20ntl according to the manufacturer’s technology. The para-water concentrate was introduced into the hydrobionts medium in the ratio of 9 ml per 1 liter of water under study. To obtain offspring, individuals were used, derived on the settled tap water (1st generation) and individuals, derived on the water “Si” - 2nd generation. One-day individuals of Daphnia magna were placed in the amount of 20pcs/l of the studied water and the entire life cycle were kept in optimal conditions: climatostat P-2 (temperature - 20±1°C, illumination - 1200-2500lux, photoperiod - 12/12) hour. Feeding of Daphnia was carried out by Chlorella microalgae grown on the medium “Tamiya”-50% with a density D=0.65-0.72. Results. The life expectancy of Daphnia magna hydrobionts in the non-locally activated environment (water “Si”) increases by an average of 38 days in the first generation and 50 days in the second generation, and in an environment with a potentiating additive para-water associates for 58 days (first generation) and 41 days (second generation).The life expectancy of aquatic animals is related by negative correlation with the change in values of the oxidation-reductant potential (Eh) of the environment of hydrobionts development (Corr.=-0.993 (1st generation). Both non-local water activation and spin-modification of its associated phase by para-isomers demonstrate an increase in the hydrobionts productivity: - in non-locally activated water - 1.20 (1st generation) and 2.68 (2nd generation); - in non-locally activated water with the addition of para-water - 1.39 (1st generation) and 1.97 (2nd generation) times. Conclusion. From the results it follows that the determining factor in the hydrobionts medium is its quantum coupling with electron sources in the external environment. This determines the importance of water quantum coupling with natural ecosystems, affecting cellular metabolism. Spin para modification of the associated water phase leads to an additional increase in the hydrobionts life expectancy in the first generation. In the second generation, the influence of para-water is accompanied by some decrease in both the life hydrobionts expectancy and their productivity.