The Impact of Normal Range of Serum Phosphorus on the Incidence of End-Stage Renal Disease by A Propensity Score Analysis

Chang, Wenxiu; Xu, Ning; Kumagai, Toru; Shiraishi, Takeshi; Kikuyama, Takahiro; Omizo, Hiroki; Sakai, Kazuhiro; Arai, Shigeyuki; Tamura, Yoshifuru; Ota, Tatsuru; Shibata, Shigeru; Fujigaki, Yoshihide; Shen, Zhongyang; Uchida, Shunya

doi:10.1371/journal.pone.0154469

Cited by 27 publications

(21 citation statements)

References 40 publications

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“…The meta-analysis suggested that every 1 mg/dL increase in serum Pi was independently associated with an increased risk for kidney failure (HR 1.36; 95% CI 1.20–1.55) [37]. An increased phosphate load can result in tubular injury, interstitial fibrosis, endothelial dysfunction, and vascular calcification via the direct effect of either phosphate or calciprotein particles [38]. Such findings suggest that not only a decrease in serum indoxyl sulfate but also a decrease in serum Pi might contribute to ameliorate kidney function in the current study.…”

Section: Discussionmentioning

confidence: 99%

Dietary Changes Involving Bifidobacterium longum and Other Nutrients Delays Chronic Kidney Disease Progression

et al. 2018

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Background: Recent studies suggest that prebiotic and/or probiotic treatments ameliorate kidney function in humans and animals by improving the gut environment. However, the gut microbiota and kidney disease interactions remain to be determined. This study investigated whether synbiotics modulate the gut microbiota and ameliorate kidney function using a rat model of chronic kidney disease (CKD). As uremic toxins are associated with CKD-related mineral and bone disorder, the secondary aim was to evaluate the relationship between synbiotics and secondary hyperparathyroidism (SHPT). Methods: 5/6 nephrectomy (Nx) rats were developed as the CKD model. Sham-operated (sham) rats were used as the control. To investigate the effectiveness of prebiotics (glutamine, dietary fiber, and oligosaccharide) and probiotics (Bifidobacterium longum strain; GFOB diet), rats were randomly assigned to 4 groups: Nx group fed the GFOB diet (n = 10); Nx group fed the control (CON) diet (n = 10); sham group fed the GFOB diet (n = 5); and sham group fed the control diet (n = 5). Blood, feces, and kidney samples were collected and analyzed. Results: Serum creatinine (Cre) and blood urea nitrogen in the Nx GFOB group were significantly lower than those in the Nx CON group. Serum indoxyl sulfate in the Nx GFOB group was lower than that in the Nx CON group, and significantly correlated with serum Cre. Inorganic phosphorus and intact parathyroid hormone in the Nx GFOB group were significantly lower than those in the Nx CON group. Conclusion: Improving the gut environment using synbiotics ameliorated kidney function and might be a pharmacological treatment for SHPT without any serious adverse events.

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Section: Discussionmentioning

confidence: 99%

Dietary Changes Involving Bifidobacterium longum and Other Nutrients Delays Chronic Kidney Disease Progression

et al. 2018

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“…Thus, evidence shows that hyperphosphatemia in CKD is associated with poor renal prognoses. Moreover, a study of 803 CKD patients showed that higher serum phosphate levels were associated with an increased risk of ESRD, where the HR was about 17.6 at a time-averaged phosphorus level of 3.4 mg/dL, even in patients with normal serum phosphate levels [14].…”

Section: Discussionmentioning

confidence: 99%

High Serum Phosphate Level as a Risk Factor to Determine Renal Prognosis in Autosomal Dominant Polycystic Kidney Disease: A Retrospective Study

et al. 2020

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Background: Serum phosphate levels, which are associated with the progression of renal dysfunction in chronic kidney disease, in patients with autosomal dominant polycystic kidney disease (ADPKD) are lower than those in patients with other kidney diseases. However, their role in ADPKD remains unclear. This study aimed to determine whether serum phosphate levels could have an association with renal prognoses among patients with ADPKD. Methods: In total, 55 patients with PKD1 or PKD2 mutations but not undergoing dialysis were evaluated. Data regarding serum phosphate levels were collected, and Cox regression analyses were used to calculate hazard ratios (HRs) with renal replacement therapy as the endpoint. Results: The median (quartile 1; quartile 3) serum phosphate concentration was 3.4 (3.1; 3.9) mg/dL, and the estimated glomerular filtration rate (eGFR) was 39.5 (17.6; 65.7) mL/min/1.73 m2. The multivariate analysis that included age, PKD1 mutation, eGFR, urinary protein excretion, hyperuricemia, and serum phosphate determined that eGFR (HR, 0.82; 95% confidence interval (CI), 0.74–0.90; p < 0.0001) and serum phosphate (HR, 6.78; 95% CI, 1.94–34.02; p = 0.0021) were independently associated with renal replacement therapy. Conclusions: We found that serum phosphate levels were significantly associated with poor renal prognoses in patients with ADPKD.

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“…Depend on studies the important risk factors for involving in ESRD are hyperphosphatemia, hypercalcemia, dyslipidemia, and hypoalbuminemia which impact on CVD morbidity directly. Especially, over normal range of P is a great risk factor of CKD patients [24,25]. Recent study indicated that 52.9% and 52% had hyperphosphatemia and hyperkalemia, respectively.…”

Section: Several Studies Have Shown An Association Between Increased mentioning

confidence: 99%

Study of Related Biochemical Tests and PTH in End Stage Renal Disease Patients in Iran

S¹,

Zarebavani²,

Einollahi³

et al. 2018

Biochem Anal Biochem

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Introduction: End-stage renal disease (ESRD) patients usually have abnormalities in various laboratory tests. The aim of this study is evaluating of the rate of various laboratory tests in ESRD patient to reduce the risk of mortality and prevent them of other diseases. Methods: In this cross-sectional study a total of 300 patients who had ESRD and had been on hemodialysis treatment for at least 6 months were selected. The laboratory tests consisted of measurement of high density lipoprotein, triglyceride, cholesterol, fasting blood sugar, parathyroid hormone, alanine transferase, aspartate transferase, alkaline phosphatase, creatinine, blood urea nitrogen, calcium, phosphorous, sodium, potassium, and albumin. Results: The study population included 52.3% males and 47.7% females with average age of 41.5 ± 14.3 years. The high serum level of Chol (˃200 mg/dL) and TG (˃160 mg/dL) are 48.7%, 32.3%, respectively. About 98% were in high risk of range HDL (˂45 mg/dL). All of participants had over normal range of BUN and about 96% of them were over normal range of Cr. Rate of high serum level of Na, K, P, and Ca were 3.7%, 52%, 54.3%, and 14.6%, respectively. Discussion: Depend the result of this study, can understand that great group of patients with ESRD have high risk serum level of lipid indexes. Recent studies showed that there is a clear correlation between HDL cholesterol and cardiovascular risk in ESRD patients and there is correlation between level of triglyceride level and CKD progression. The important risk factors for involving in ESRD are hyperphosphatemia, hypercalcemia, dyslipidemia, and hypoalbuminemia which impact on CVD morbidity directly. Conclusion: In this study observed that most of patient with ESRD have abnormality in their lipid profiles factors, mineral electrolytes factors, and PTH. Regular laboratory checkup can control renal failure (especially ESRD patients) patients. Proper care of body, balanced diet intake, plenty water intake during the day can help them to control these diseases.

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The Impact of Normal Range of Serum Phosphorus on the Incidence of End-Stage Renal Disease by A Propensity Score Analysis

Cited by 27 publications

References 40 publications

Dietary Changes Involving <b><i>Bifidobacterium</i></b> <b><i>longum</i></b> and Other Nutrients Delays Chronic Kidney Disease Progression

Dietary Changes Involving <b><i>Bifidobacterium</i></b> <b><i>longum</i></b> and Other Nutrients Delays Chronic Kidney Disease Progression

High Serum Phosphate Level as a Risk Factor to Determine Renal Prognosis in Autosomal Dominant Polycystic Kidney Disease: A Retrospective Study

Study of Related Biochemical Tests and PTH in End Stage Renal Disease Patients in Iran

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