The Impact of Obesity and Metabolic Syndrome in COPD

Sava, Francesco; Maltais, François; Poirier, Paul

doi:10.5772/21011

Cited by 2 publications

(2 citation statements)

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“…One study found no difference between normal-weight and obese patients in terms of FEV 1 and FEV 1 /Forced vital capacity (FVC) values (18), whereas another study found FEV 1 values to be significantly lower in normal-weight patients as compared to the overweight and obese patients (19). Moreover, in another study both FEV 1 and FEV 1 /FVC values were found to be significantly higher in obese versus non-obese patients (20). In our study, there was no significant difference between the groups in terms of FEV 1 values, but the FEV 1 / FVC value was significantly higher in the obese patients.…”

Section: Discussionmentioning

confidence: 95%

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Does Increased Body Mass Index Effect the Gains of Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease Patients?

Şahin¹,

Naz²,

Varol³

et al. 2017

Eurasian J Pulmonol

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Obesity is one of the most important public health problems, and it is increasing in prevalence worldwide (1,2). Obesity is an inflammatory disease that involves many systems in the body, especially the respiratory system, causing changes in pulmonary functions (2). Chronic obstructive pulmonary disease (COPD) is also an important public health problem usually accompanied by nutritional abnormalities (3, 4). The majority of COPD patients are overweight or obese rather than normal or low-weight (4). Obesity and COPD cause mortality and morbidity all over the world, and this global outbreak is predicted to be much higher in the future (5). Obesity might be the reason for respiratory symptoms alone due to decreased pulmonary compliance, increased work in breathing, and increased need for oxygen, even without airway obstruction. However, obesity might also increase the numbers of obstructed peripheral airways (6). It was determined that dyspnea perception is enhanced, health status is impaired, and quality of life (QOL) is reduced in obese COPD patients compared to non-obese COPD patients (7,8). It has been shown that pulmonary rehabilitation (PR) reduces dyspnea, enhances exercise performance, improves QOL, and decreases psychological symptoms in COPD patients (9). The present study aimed to compare the gains of PR in obese, pre-obese, and normal-weight COPD patients who completed an 8-week outpatient PR program. AbstractObjective: We aimed to compare the gain of pulmonary rehabilitation (PR) in obese, pre-obese, and normal-weight patients with chronic obstructive pulmonary disease (COPD) who underwent a PR program.Methods: COPD patients (n=137) underwent pulmonary and cardiac system examination and pulmonary function tests (PFTs) before PR. Chest X-rays, arterial blood gases, body mass index, quality of life (QOL) questionnaires, anxiety and depression scores, and Modified Medical Research Council dyspnea scale (MMRC) scores were evaluated in all patients. A 6-min walk test was performed to determine the exercise capacity of the patients. All patients underwent an 8-week outpatient PR program. The patients were reevaluated at the end of 8th week in terms of all parameters. Results:The study group consisted of 44 normal-weight, 52 pre-obese, and 41 obese COPD patients. Before PR, there was no significant difference in terms of 6-min walk distance (6MWD), PFT, MMRC, or QOL scores between the groups (p>0.05 for all). After PR, partial arterial oxygen pressure and arterial saturation, MMRC, and QOL scores improved significantly in all three groups (p<0.05 for all). 6MWD and walkwork significantly increased after PR in all three groups (p<0.001 for all), but the gain in 6MWD was significantly lower in obese patients compared to pre-obese and normal-weight patients (p=0.049). Conclusion:Pre-obese and obese patients benefit from PR similarly to the normal-weight patients in terms of gas exchange, dyspnea perception, and QOL. But it seems to be that exercise capacity improves less in obese COPD patients compared to pre-o...

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Section: Discussionmentioning

confidence: 95%

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mentioning

confidence: 99%

Does Increased Body Mass Index Effect the Gains of Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease Patients?

Şahin¹,

Naz²,

Varol³

et al. 2017

Eurasian J Pulmonol

View full text Add to dashboard Cite

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Obesity and metabolic disorders in COPD patients: opportunities for phenotyping

Самулеева¹,

Задионченко²,

Ли³

et al. 2014

Pulʹmonologiâ (Mosk.)

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1 -ГБОУ ВПО "Московский государственный медико стоматологический университет им. А.И.Евдокимова" Минздрава России: 127473, Москва, ул. Делегатская, 20 / 1; 2 -ГБУЗ "Городская клиническая больница № 11" Департамента здравоохранения г. Москвы: 127018, Москва, ул. Двинцев, 6 РезюмеЦелью исследования явилось изучение клинико функциональных параметров и качества жизни (КЖ) больных хронической обструк тивной болезнью легких (ХОБЛ) c сопутствующим ожирением и метаболическими нарушениями с оценкой возможности их феноти пирования. На основании кластерного анализа, проведенного по методу k средних МакКуина, выделены 4 группы пациентов с отличи тельными особенностями течения ХОБЛ. Установлено, что наличие сопутствующего ожирения у больных ХОБЛ ассоциировано со значительным снижением легочной функции, переносимости физической нагрузки, показателей КЖ и выживаемости, частыми обост рениями, развитием инсулинорезистентности и активацией системных воспалительных реакций. Предполагается, что клинический вариант ХОБЛ с сопутствующим ожирением целесообразно рассматривать в качестве отдельного фенотипа заболевания, характеризу ющегося тяжелым течением. Ключевые слова: хроническая обструктивная болезнь легких, ожирение, инсулинорезистентность, фенотип, тяжелое течение, кластер ный анализ. Obesity and metabolic disorders in COPD patients: opportunities for phenotyping SummaryThe aim of the study was to compare clinical and functional features and health related quality of life (HRQoL) in patients with chronic obstructive pulmonary disease (COPD) regarding to co morbid obesity as a phenotypic sign. Methods. Patient classification was performed using K means clus tering analysis (MacQueen). It resulted in the classification of subjects into four clinical groups with marked differences in COPD symptoms. Results. Subjects with obesity had severe airflow limitation and dyspnoea, frequent exacerbations, severely impaired HRQoL, poor survival, decreased physical activity, insulin resistance and increased systemic inflammation. Conclusion. Thus, COPD with co morbid obesity could be con sidered as a distinct phenotype of COPD with severe symptoms.

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The Impact of Obesity and Metabolic Syndrome in COPD

Cited by 2 publications

References 42 publications

Does Increased Body Mass Index Effect the Gains of Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease Patients?

Does Increased Body Mass Index Effect the Gains of Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease Patients?

Obesity and metabolic disorders in COPD patients: opportunities for phenotyping

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