The impact of obesity and adiponectin signaling in patients with renal cell carcinoma: A potential mechanism for the “obesity paradox”

Ito, Ryuzo; Narita, Shintaro; Huang, Mingguo; Nara, Taketoshi; Numakura, Kazuyuki; Takayama, Kenji; Maeno, Akihiro; Saito, Mitsuru; Inoue, Takamitsu; Tsuchiya, Norihiko; Satoh, Shigeru; Habuchi, Tomonori

doi:10.1371/journal.pone.0171615

Cited by 37 publications

(26 citation statements)

References 30 publications

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“…Of interest, it is also recently reported that circulating adiponectin levels are inversely correlated with BMI and directly correlated with the obesity paradox observed in patients with renal cell carcinoma. 48 This is in line with a previous report on patients with renal cell carcinoma showing that tumor development in an obesogenic environment may become less aggressive. 49 This epidemiological study also correlated genomewide signatures of tumor with BMI and survival; fatty acid metabolic genes, especially the fatty acid synthase gene (FASN), were found to underlie the differential outcomes of tumor.…”

Section: Adipokines and Endocrine Changessupporting

confidence: 91%

“…This is clearly problematic given the existence of obese patients who are metabolically healthy and patients who are metabolically obese but of normal weight. 48 These limitations of BMI in the evaluation of obesity may explain in part the discrepancy in the effect of obesity in lung cancer and many other types of cancer. 9 Given the biological complexity of obesity and current knowledge gaps, dual body weight and body composition assessment seems necessary to provide accurate information about the type and severity of obesity.…”

Section: Clinical Implications and Future Perspectivesmentioning

confidence: 99%

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Obesity Paradox in Lung Cancer Prognosis: Evolving Biological Insights and Clinical Implications

Zhang

Liu

Shao

et al. 2017

Journal of Thoracic Oncology

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The survival rate of lung cancer remains low despite the progress of surgery and chemotherapy. With the increasing comorbidity of obesity in patients with lung cancer, new challenges are emerging in the management of this patient population. A key issue of interest is the prognostic effect of obesity on surgical and chemotherapeutic outcomes in patients with lung cancer, which is fueled by the growing observation of survival benefits in overweight or obese patients. This unexpected inverse relationship between obesity and lung cancer mortality, called the obesity paradox, remains poorly understood. The evolving insights into the heterogeneity of obesity phenotypes and associated biological connections with lung cancer progression in recent years may help explain some of the seemingly paradoxical relationship, and well-designed clinical studies looking at the causal role of obesity-associated molecules are expected. Here, we examine potential biological mechanisms behind the protective effects of obesity in lung cancer. We highlight the need to clarify the clinical implications of this relationship toward an updated intervention strategy in the clinical care of patients with lung cancer and obesity.

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Section: Adipokines and Endocrine Changessupporting

confidence: 91%

Section: Clinical Implications and Future Perspectivesmentioning

confidence: 99%

Obesity Paradox in Lung Cancer Prognosis: Evolving Biological Insights and Clinical Implications

Zhang

Liu

Shao

et al. 2017

Journal of Thoracic Oncology

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“…Recently, it has been demonstrated that adipocytes contribute to EMT, invasion, proliferation and progression, in several cancer types [83][84][85][86][87]. Nie et al, [88] found that co-culture with adipocytes led CCA cells to express mesenchymal biomarkers overexpression and cell-to-cell adhesion alteration.…”

Section: Lipid Metabolism In Ccamentioning

confidence: 99%

Multifaceted Aspects of Metabolic Plasticity in Human Cholangiocarcinoma: An Overview of Current Perspectives

Pastore

Lori

Gentilini

et al. 2020

Cells

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Cholangiocarcinoma (CCA) is a deadly tumor without an effective therapy. Unique metabolic and bioenergetics features are important hallmarks of tumor cells. Metabolic plasticity allows cancer cells to survive in poor nutrient environments and maximize cell growth by sustaining survival, proliferation, and metastasis. In recent years, an increasing number of studies have shown that specific signaling networks contribute to malignant tumor onset by reprogramming metabolic traits. Several evidences demonstrate that numerous metabolic mediators represent key-players of CCA progression by regulating many signaling pathways. Besides the well-known Warburg effect, several other different pathways involving carbohydrates, proteins, lipids, and nucleic acids metabolism are altered in CCA. The goal of this review is to highlight the main metabolic processes involved in the cholangio-carcinogeneis that might be considered as potential novel druggable candidates for this disease.

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“…In the course of some malignancies a paradoxical phenomenon has been observed, indicating that obesity may be an oncogenic factor and -at the same time -may constitute a favorable prognostic factor (4,5). The dual and opposite influence of obesity on the course of the same disease has been called the obesity paradox and has been described in some chronic diseases, including cardiovascular (6) and cerebrovascular diseases (7).…”

mentioning

confidence: 99%

Influence of Obesity on the Course of Malignant Neoplastic Disease in Patients After Pulmonary Metastasectomy

Rzechonek

Błasiak

Pniewski³

et al. 2018

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Abstract. Background (82.1±83.5 months vs. 43.0±44.4, p<0.01 and 110.7±81.3 months vs. 69.9±52.9 p<0.005, respectively). Survival after pulmonary metastasectomy was 27.2±25.6 months and was longer in obese and overweight patients than in normal weight patients (20.2±18.4 months vs. 29.4±26.5, p<0.05). Conclusion: Being obese or overweight is a favorable prognostic factor in patients after surgical resection of lung metastases of different malignancies.With the increasing epidemic of obesity in the world, the incidence of malignancies related to obesity also increases (1). Obesity-related cancers include breast cancer in postmenopausal women, colon cancer, cancer of the lower esophagus, gastric cancer, liver cancer, gall bladder cancer, pancreatic cancer, uterine cancer, ovarian cancer and renal cancer (2). Obesity is also associated with increased risk of metastases, including lung metastases, in some cancers (3).In the course of some malignancies a paradoxical phenomenon has been observed, indicating that obesity may be an oncogenic factor and -at the same time -may constitute a favorable prognostic factor (4, 5). The dual and opposite influence of obesity on the course of the same disease has been called the obesity paradox and has been described in some chronic diseases, including cardiovascular (6) and cerebrovascular diseases (7). These paradoxical effects of obesity may occur also in patients with metastases, including patients with malignancies not related to obesity. In a recent large-scale study of 4,010 cancer patients in good general condition, with distant metastases, median OS was twice as high in obese patients as in normal weight patients (8). However, there are also reports stating that there is no beneficial effect of obesity on metastatic neoplastic disease (9-11).The problem of the influence of obesity on the course of metastatic malignancies has not yet been unequivocally explained. Especially, there are no studies on the influence of obesity on survival of patients with operable lung metastases. Therefore, this study was undertaken to evaluate the long-term outcome of surgical treatment of obese and non-obese patients who after resection of primary neoplasm had lung metastases removed. Materials and MethodsData from 99 patients who had a resection of lung metastasis from different primary malignancies between 2001 and 2016 were analyzed. The study was retrospective, and the condition for including patients in the study was access to anesthesia documentation containing body weight and height prior to performing pulmonary metastasectomy. Analysis was performed in the groups depending on body mass index (BMI). Underweight was diagnosed when the BMI 197

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The impact of obesity and adiponectin signaling in patients with renal cell carcinoma: A potential mechanism for the “obesity paradox”

Cited by 37 publications

References 30 publications

Obesity Paradox in Lung Cancer Prognosis: Evolving Biological Insights and Clinical Implications

Obesity Paradox in Lung Cancer Prognosis: Evolving Biological Insights and Clinical Implications

Multifaceted Aspects of Metabolic Plasticity in Human Cholangiocarcinoma: An Overview of Current Perspectives

Influence of Obesity on the Course of Malignant Neoplastic Disease in Patients After Pulmonary Metastasectomy

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