The Impact of Partial Vascular Occlusion on Oxidative Stress Markers during Resistance Exercise

Garten, Ryan S.; Goldfarb, Allan H.; Crabb, B.; Waller, Justin D.

doi:10.1055/s-0034-1396827

Cited by 14 publications

(32 citation statements)

References 48 publications

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“…Oxidative stress can occur when the generation of reactive oxygen species (ROS) exceeds the ability of the antioxidant system to reduce the molecules (Garten et al, 2015). Deflation of a tourniquet cuff is associated with an increase in ROS and has been directly associated with ischemic reperfusion injuries after orthopedic surgery (Cheng et al, 2003).…”

Section: Application Of Bfrmentioning

confidence: 99%

“…Furthermore, one exercise bout or 1 week of high-frequency BFR-RE (1–2 sessions per day/3 weeks; 20–30%-1RM) does not appear to augment oxidative stress or antioxidant enzyme response (Nielsen et al, 2017a; Centner et al, 2018b). However, moderate intensity (70% 1RM) exercise with or without BFR both significantly elevated oxidative stress (Garten et al, 2015). Thus, overall the addition of BFR to LL-RE does not appear to increase oxidative stress or antioxidant defense, thus oxidative stress formation may be load, rather than BFR-dependent.…”

Section: Application Of Bfrmentioning

confidence: 99%

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Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety

Patterson¹,

Hughes²,

et al. 2019

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The current manuscript sets out a series of guidelines for blood flow restriction exercise, focusing on the methodology, application and safety of this mode of training. With the emergence of this technique and the wide variety of applications within the literature, the aim of this review is to set out a current research informed guide to blood flow restriction training to practitioners. This covers the use of blood flow restriction to enhance muscular strength and hypertrophy via training with resistance and aerobic exercise and preventing muscle atrophy using the technique passively. The authorship team for this article was selected from the researchers focused in blood flow restriction training research with expertise in exercise science, strength and conditioning and sports medicine.

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Section: Application Of Bfrmentioning

confidence: 99%

Section: Application Of Bfrmentioning

confidence: 99%

Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety

Patterson¹,

Hughes²,

et al. 2019

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“…In resistance-trained men, Goldfarb et al (2008) demonstrated an increase in protein carbonyls and GSSG/GSH ratio after arm curl resistance exercise (70% 1-RM) to failure, while no change was observed with a partial BFR protocol (30% 1-RM). Evidence indicates that moderate to high-load resistance exercise can acutely elevate biomarkers of oxidative stress ( Garten et al, 2015 ; da Silva et al, 2016 ). Our results reveal that performing RT with total BFR may elicit comparable metabolic disturbance and ROS generation during exercise versus high-load RT ( Suga et al, 2012 ; Kim et al, 2014 ) despite the lower external load.…”

Section: Discussionmentioning

confidence: 99%

Effect of Resistance Training With Total and Partial Blood Flow Restriction on Biomarkers of Oxidative Stress and Apoptosis in Untrained Men

et al. 2021

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Introduction: The characterization of immune and oxidative stress responses to acute and chronic exercise training is important because it may aid in the safety and dose–response prescription of resistance training (RT) in many populations.Purpose: The present study compared changes in acute oxidative stress and markers of apoptosis in immune cells before and after 8 weeks of low-load RT with total or partial blood flow restriction (BFR) versus high-load traditional RT.Methods: Twenty-seven untrained men were randomly divided into three groups: traditional RT [75% one-repetition maximum (1-RM)], RT with partial (20% 1-RM), and total BFR (20% 1-RM). Over an 8-week period, participants performed six sets of arm curls until failure with 90 seconds of recovery for 3 days/week. Blood samples were obtained before and after the first and last training sessions.Results: Data indicated that all training groups showed similar increases in muscular strength (p < 0.001), reduction in mitochondrial membrane potential (MMP) after exercise in neutrophils (p < 0.001), and increase in caspase-3 activity after exercise (p < 0.001). Traditional RT and total BFR showed increased plasma lipid peroxidation (p < 0.001) and protein carbonyls (p < 0.001) and lower levels of reduced glutathione (GSH) (p < 0.001) after exercise. No change was observed in oxidative stress biomarkers in response to partial BFR (p > 0.05).Conclusion: Data show that RT with partial BFR can increase muscular strength but still does not augment biomarkers of oxidative stress in untrained men. In addition, RT with total BFR promoted similar responses of oxidative stress and markers of immune cell apoptosis versus traditional RT.

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“…According to Garten et. al., (2015) [23] this appears to occur because the continued arterial flow may change circulating antioxidants, reducing the accumulation in ROS proceeding from vasculature and muscle. However, this mechanism is debatable because the flow is constantly altered during the contractions with or without occlusion.…”

Section: Discussionmentioning

confidence: 99%

Effects of Acute Exercise with Blood Flow Restriction on Oxidative Stress Biomarkers

Ramis¹,

Medeiros²,

Muller³

et al. 2017

sports

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The aim of this study was to assess the effects of an acute session of resistance exercise with blood flow restriction in modulation of oxidative stress parameters at different moments. Eleven participants (23.72 ± 3.49 years and 81.51 ± 6.10 kg) were recruited to perform a crossover design with three protocols: high intensity resistance exercise (HI 80% 1RM), low intensity resistance exercise (LI 30% 1RM), and with blood flow restriction (LI-BFR 30% 1RM). The oxidative profile in an acute session at four moments was assessed: baseline, immediately after exercise, and 24 and 48 hours later. The Ethics Committee at the Methodist University Center-IPA (Porto Alegre, Brazil) approved this study. The results did not show statistical significance (p>0.05) among moments and among groups for TBARS and protein carbonyls. Likewise, for the antioxidant activity there was also no difference (p>0.05) among moments and groups for sulfhydryl groups. The superoxide dismutase enzyme demonstrated a significant reduction (p<0.05) between baseline and immediately after exercise in the LI-BFR group. After group comparison, the HI group showed a significant increase (p<0.05) in baseline and 24 hours when compared to the LI-BFR. An equal increase was observed in the HI group at the moment of 24 hours later when compared to the LI group. The catalase enzyme levels in the LI group were significantly higher than in the LI-BFR and HI groups at baseline and 24 hours (p<0.05) later. Lastly, the low intensity resistance exercise with blood flow restriction in maximum repetition appears not to have modified the oxidative profile in young and healthy subjects, suggesting that the hypertrophy mechanism of that methodology of training occurred in other molecular ways.

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The Impact of Partial Vascular Occlusion on Oxidative Stress Markers during Resistance Exercise

Cited by 14 publications

References 48 publications

Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety

Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety

Effect of Resistance Training With Total and Partial Blood Flow Restriction on Biomarkers of Oxidative Stress and Apoptosis in Untrained Men

Effects of Acute Exercise with Blood Flow Restriction on Oxidative Stress Biomarkers

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