The impact of Platelet Rich Plasma (PRP) in osseointegration of oral implants in dental panoramic radiography: texture based evaluation

Georgakopoulos, Ioannis; Tsantis, Stavros; Georgakopoulos, Panagiotis; Korfiatis, Panagiotis; Fanti, Elena; Martelli, Marialaura; Costaridou, Lena; Petsas, Theodoros; Panayiotakis, George; Martelli, Francesco

doi:10.11138/ccmbm/2014.11.1.059

Cited by 22 publications

(23 citation statements)

References 29 publications

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“…These growth factors have shown their potentials to stimulate cell proliferation and differentiation(Badran, Abdallah, Torres, & Tamimi, 2018). The current results are consistent with some clinical findings(Gentile, Bottini, Spallone, Curcio, & Cervelli, 2010;Georgakopoulos et al, 2014), which indicate further that local application of PRP has positive effects on peri-implant trabecular bone remodeling in dental implant surgery, such as increased the numbers of osteogenic cells and faster rate of bone maturation, while the PPP could sufficiently maintain bone width and height with no depression for the preservation of socket with buccal dehiscence(Hatakeyama, Marukawa, Takahashi, & Omura, 2014).TA B L E 2 The average concentration of platelets in whole blood, PPP, and PRP (mean and SD, ×10 9 /L) *, *** significant differences indicate, respectively, p < .005 and p < .0001 while comparing with whole blood samples. Abbreviations: PPP, platelet-poor plasma; PRP, platelet-rich plasma.…”

supporting

confidence: 91%

Effect of platelet‐rich plasma on peri‐implant trabecular bone volume and architecture: A preclinical micro‐CT study in beagle dogs

Huang

Dessel

et al. 2019

Clinical Oral Implants Res

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Objectives To evaluate the peri‐implant trabecular bone volume and architecture changes with 6‐month follow‐up after local application of platelet‐rich plasma (PRP) and platelet‐poor plasma (PPP) using high‐resolution micro‐CT. Material and methods Seventy‐two dental implants were placed into healed mandibular sites of 9 beagle dogs. Implants were randomly divided into 4 groups following a split‐mouth design: control I; control II; PPP; and PRP. Primary and secondary stabilities were assessed using resonance frequency analyses. At 1, 3, and 6 months after implant loading, trabecular structural parameters were evaluated at 0.5, 1, and 1.5 mm away from implants using micro‐CT (voxel = 20 μm). Results Primary and secondary stabilities were equivalent in all conditions. PPP and PRP groups showed higher bone volume fraction (BV/TV) and trabecular thickness (Tb.Th) but lower trabecular separation (Tb.Sp) and total porosity percentage (Po (tot)) at all 3 time points. A significant decrease in BV/TV and Tb.Th was found for the control groups after 3 months of healing, while this was not observed in both the PPP and PRP groups. However, no distinct difference was found between the PRP and PPP groups over time. Moreover, as the investigated distance from the implant surface increased, BV/TV and Po (tot) within the same group and time point stayed the same, yet Tb.Th and Tb.Sp continued to increase. Conclusions Platelet‐rich plasma and PPP with conventional implant placement lead to similar primary and secondary implant stability, but improved peri‐implant bone volume and structural integration. The present research does not seem to suggest a different bone remodeling pattern when using PRP or PPP.

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supporting

confidence: 91%

Effect of platelet‐rich plasma on peri‐implant trabecular bone volume and architecture: A preclinical micro‐CT study in beagle dogs

Huang

Dessel

et al. 2019

Clinical Oral Implants Res

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“…Only one study performed GBR (ArRejaie et al., ). PRP enhancing bone formation was found in two studies (ArRejaie et al., ; Georgakopoulos et al., ). This was associated with larger bone width, higher bone density and less marginal bone loss (ArRejaie et al., ; Georgakopoulos et al., ).…”

Section: Resultsmentioning

confidence: 93%

“… SFE (Table ): n = 12 (Bettega et al., ; Cabbar, Guler, Kurkcu, Iseri, & Sencift, ; Consolo, Zaffe, Bertoldi, & Ceccherelli, ; Del Fabbro, Corbella, Ceresoli, Ceci, & Taschieri, ; Kumar, Shaik, Nadella, & Chintapalli, ; Schaaf, Streckbein, Lendeckel, Heidinger, Rehmann, et al., ; Schaaf, Streckbein, Lendeckel, Heidinger, Gortz, et al., ; Stenport, Ortorp, & Thor, ; Thor, Sennerby, Hirsch, & Rasmusson, ; Thor, Wannfors, Sennerby, & Rasmusson, ; Torres et al., ; Wiltfang et al., ). Alveolar bone regeneration (Table and ): (a) Alveolar ridge preservation (Table ) n = 4 (Alissa, Esposito, Horner, & Oliver, ; Anitua et al., ; Farina, Bressan, Taut, Cucchi, & Trombelli, ; Mozzati et al., ). (b) Alveolar ridge augmentation (Table ) n = 2 (Eskan et al., ; Torres et al., ). Dental implants (Table ): n = 4 (ArRejaie, Al‐Harbi, Alagl, & Hassan, ; Georgakopoulos et al., ; Kundu & Rathee, ; Monov et al., ). …”

Section: Resultsmentioning

confidence: 99%

The use of platelet‐rich plasma to enhance the outcomes of implant therapy: A systematic review

Stähli

Strauß

Gruber

2018

Clinical Oral Implants Res

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ObjectiveTo assess the effect of platelet‐rich plasma (PRP) on implant dentistry. The primary focused question was as follows: What are the clinical, histological, and radiographic outcomes of PRP administration for bone regeneration and implant therapy?MethodsA literature search was conducted involving three databases: MEDLINE, EMBASE and Cochrane database followed by a hand search of relevant scientific journals. Human studies using PRP for bone regeneration and implant therapy were considered and articles published up to December 31, 2017 were included. Eligible studies were selected based on the inclusion criteria, and quality assessments were conducted.ResultsIn total, out from the 9,497 titles meeting the original search criteria, 22 fulfilled the inclusion criteria and were chosen for data extraction. Among them were 15 randomized controlled trials (RCT) and seven controlled clinical trials (CCT). Overall, the risk of bias was moderate to high. A total of seven studies showed superior outcomes when PRP was added during sinus floor elevation and five showed no superior outcome. Three studies found a significant advantage of PRP for alveolar bone regeneration and another three studies for soft tissue healing. Three studies reported on beneficial effects of PRP directly during implant placement while another study failed to find significant differences. Due to the heterogeneity of study designs, no meta‐analysis could be performed.Summary and ConclusionsDespite the lack of consistent evidence supporting the clinical benefit of PRP in healthy patients, PRP might have a positive effect on wound healing and bone regeneration in compromised patients.

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“…The results showed that the addition of PRP may be beneficial since a significant positive effect occurred 43 . D'Aquino et al 44 performed autologous DPSC grafts in 7 patients (followed up for 1 year) who presented bone resorption in the second molar distal due to impacted inferior third molars.…”

Section: Therapies For the Regeneration Of Bone Tissuementioning

confidence: 75%

What is the clinical applicability of regenerative therapies in dentistry?

Demarco

Kirschnick

Watson

et al. 2017

RGO, Rev. Gaúch. Odontol.

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Regenerative therapies have been widely developed in dentistry and it is important to incorporate dentists' knowledge of these new therapies RESUMOTerapias regenerativas vem sendo amplamente desenvolvidas na odontologia e o conhecimento destas novas terapias por parte dos dentistas é importante para que elas sejam incorporadas na rotina clínica odontológica. Assim, este estudo revisou a literatura acerca das terapias regenerativas e suas aplicações clínicas. A engenharia tecidual tem contribuído na mudança do paradigma restaurador das ciências da saúde. Seus pilares embasam as técnicas de regeneração de tecidos e órgãos. Apesar da grande maioria dos estudos neste campo ser in vitro, uma gama de metodologias pré-clínicas foi consolidada e estudos utilizando estes princípios já estão sendo empregados em humanos. A utilização de plasma rico em plaquetas e plasma rico em fibrina como scaffolds naturais em cirurgias para reestabelecimento de tecido ósseo e periodontal são frequentemente relatadas na literatura e ensaios clínicos utilizando esta abordagem demonstram resultados promissores. Células-tronco da polpa dental autólogas já foram aplicadas com sucesso na regeneração de tecido ósseo utilizando scaffold naturais de colágeno em humanos. Além disto, a revascularização do canal radicular já aparece na literatura como uma alternativa promissora frente a opção de apecificação do canal radicular. Esta terapia utiliza como princípio o coágulo sanguíneo como scaffold e a migração das células-tronco da papila apical para regenerar o órgão pulpar. Considerações finais: Apesar de incipientes, as terapias regenerativas já podem ser utilizadas na prática clínica odontológica. O conhecimento dos princípios que regem estas terapias deve ser compreendido pelo dentista para que sejam utilizadas na prática clínica.Termos de indexação: Fibrina. Plasma rico em plaquetas. Células-tronco. Engenharia tecidual.

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The impact of Platelet Rich Plasma (PRP) in osseointegration of oral implants in dental panoramic radiography: texture based evaluation

Cited by 22 publications

References 29 publications

Effect of platelet‐rich plasma on peri‐implant trabecular bone volume and architecture: A preclinical micro‐CT study in beagle dogs

Effect of platelet‐rich plasma on peri‐implant trabecular bone volume and architecture: A preclinical micro‐CT study in beagle dogs

The use of platelet‐rich plasma to enhance the outcomes of implant therapy: A systematic review

What is the clinical applicability of regenerative therapies in dentistry?

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