2020
DOI: 10.4149/bll_2020_131
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The impact of propranolol on apoptosis in cutaneous squamous cell carcinomas

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“…In a mouse model of ovarian cancer, it was shown that propranolol treatment reversed the β-adrenergic activation-induced tumor angiogenesis by blocking cAMP-PKA signaling pathway (40). Propranolol exerts its antitumorigenic effects not only by blocking angiogenesis but also through triggering apoptosis and/or suppressing anti-apoptotic mediators and inhibiting proliferation, invasion/metastasis of tumor cells (41,42).…”
Section: Discussionmentioning
confidence: 99%
“…In a mouse model of ovarian cancer, it was shown that propranolol treatment reversed the β-adrenergic activation-induced tumor angiogenesis by blocking cAMP-PKA signaling pathway (40). Propranolol exerts its antitumorigenic effects not only by blocking angiogenesis but also through triggering apoptosis and/or suppressing anti-apoptotic mediators and inhibiting proliferation, invasion/metastasis of tumor cells (41,42).…”
Section: Discussionmentioning
confidence: 99%