THE IMPACT of RAMADAN on PEPTIC ULCER PERFORATION

Gökakın, Ali Kağan; Kurt, Atilla; Atabey, Mustafa; Koyuncu, Ayhan; Topçu, Ömer; Aydın, Cengiz; Şen, Metin; Akgöl, Gündüz

doi:10.5505/tjtes.2012.61257

Cited by 14 publications

(24 citation statements)

References 24 publications

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“…A diurnal peak of ulcer perforations has been observed with more perforations occurring in the morning, possibly related to circadian variation in acid-secretion. Perforation risk is increased by fasting, such as during Ramadan, 35 which may also be due to variation in acid release and exposure. Ulcer perforation is noted to occur after bariatric surgery, 36 after crack-cocaine or amphetamine use, 37 , 38 and after chemotherapy with angiogenesis inhibitors such as bevacizumab.…”

Section: Pathogenesis Aetiology and Risk Factors For Perforationmentioning

confidence: 99%

Perforated peptic ulcer

et al. 2015

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SummaryPerforated peptic ulcer (PPU) is a frequent emergency condition worldwide with associated mortality up to 30%. A paucity of studies on PPU limits the knowledge base for clinical decision-making, but a few randomised trials are available. While Helicobacter pylori and use of non-steroidal anti-inflammatory drugs are frequent causes of PPU, demographic differences in age, gender, perforation location and aetiology exist between countries, as do mortality rates. Clinical prediction rules are used, but accuracy varies with study population. Early surgery, either by laparoscopic or open repair, and proper sepsis management are essential for good outcome. Selected patients can perhaps be managed non-operatively or with novel endoscopic approaches, but validation in trials is needed. Quality of care, sepsis care-bundles and postoperative monitoring need further evaluation. Adequate trials with low risk of bias are urgently needed for better evidence. Here we summarize the evidence for PPU management and identify directions for future clinical research.

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Section: Pathogenesis Aetiology and Risk Factors For Perforationmentioning

confidence: 99%

Perforated peptic ulcer

et al. 2015

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“…Gökakin et al [25] performed a retrospective study of 229 patients (195 males, 34 females; 16-85 years, median 45 years; 107 with at least one comorbidity; only 44 patients regularly taking medication with perforated peptic ulcers from January 1999 to December 2009. A total of 41 patients had undergone operations during Ramadan, with 4.1 operations per month compared with 188 patients with 1.7 operations per month.…”

Section: Ulcer Diseasementioning

confidence: 99%

Ramadan fasting and infectious diseases: a systematic review

Bragazzi

Briki

Khabbache

et al. 2015

J Infect Dev Ctries

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Ramadan represents the fourth of the five pillars of the Islamic creed. Although patients are exempted from observing this duty, they may be eager to share this moment of the year with their peers. However, there are no guidelines that can help physicians to address the concerns of patients with infectious diseases fasting during Ramadan. For this purpose, we performed a systematic review. of 51 articles. Our main findings are that: 1) patients suffering from diabetes at risk of developing infectious complications should not fast; 2) Ramadan fasting has little impact on diarrheal patients; 3) HIV represents a challenge, and ad hoc drug combinations should be recommended to patients, and the patients should be advised not to take fatty meals that could interfere with the treatment; 4) Ramadan has no effect on the effectiveness of anti-helminthic therapy; and 5) patients with active ulcers should not fast, as they have a higher probability of developing complications.

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“…The Boey scoring system is used to predict the prognosis of patients with PUP. The calculation evaluates the risk factors of time since perforation, the presence of preoperative shock, and concomitant disease [1] . The patients were divided into 2 groups based on survival, and the differences between those who survived and those who did not were assessed.…”

Section: Methodsmentioning

confidence: 99%

“…A s a result of developments in medical treatment, the need for elective surgery for uncomplicated peptic ulcer disease (PUD) has decreased [1] . Peptic ulcer perforation (PUP) is a complication of PUD that requires emergency surgery [2] .…”

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confidence: 99%

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Factors affecting mortality in patients who underwent primary suture repair for peptic ulcer perforation

Işık¹,

Dündar²,

Bakar³

et al. 2017

Haydarpasa Numune Med J

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Introduction: Primary suture is the most commonly used emergency surgery procedure for peptic ulcer perforation (PUP). The aim of this study was to evaluate factors affecting mortality in patients who underwent primary suture for PUP. Methods: In total, 103 patients underwent primary suture for PUP between September 2009 and December 2016. Patient demographics, comorbidities, the time interval between symptom onset and hospital admission, the length of hospital stay, and morbidity and mortality data were retrospectively collected. Results: The median age of the patients was 63 years (min: 22, max: 99 years) and 74.8% were male. In all, 45 patients had at least 1 comorbidity. The median time interval between symptom onset and hospital admission was 1 day (min: 1, max: 10 days). The mortality rate was 10.7%. Non-surviving patients were older, more frequently presented with shock, and more often had postoperative pneumonia, compared with survivors. Older age (Odds ratio [OR]: 1.22; p=0.0015) and postoperative pneumonia (OR: 84.2; p=0.0031) were independent risk factors associated with increased mortality. Discussion and Conclusion: Advanced age and postoperative pneumonia were the factors associated with an increased risk of mortality in patients who underwent primary suture for PUP.

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THE IMPACT of RAMADAN on PEPTIC ULCER PERFORATION

Cited by 14 publications

References 24 publications

Perforated peptic ulcer

Perforated peptic ulcer

Ramadan fasting and infectious diseases: a systematic review

Factors affecting mortality in patients who underwent primary suture repair for peptic ulcer perforation

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