The impact of skin disease following renal transplantation on quality of life

Moloney, Fergal J.; Keane, Stephen; O’Kelly, Patrick; Conlon, Peter J.; Murphy, Gillian

doi:10.1111/j.1365-2133.2005.06699.x

Cited by 79 publications

(54 citation statements)

References 17 publications

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“…Solid organ transplantation, however, carries an increased risk of cancer, and it is significant that the most frequent type of lesions that develop among transplant recipients is NMSC [4]. These represent approximately 40% to 53% of the diagnosed tumors in this group [5] and have a measurable impact upon patient morbidity and quality of life [6]. In a typical European renal transplant population, it is estimated that 1 patient in 5 will develop a neoplastic lesion by 15 years posttransplantation, rising to 2 in 5 by 20 years posttransplantation [7].…”

Section: Introductionmentioning

confidence: 99%

The higher incidence of squamous cell carcinoma in renal transplant recipients is associated with increased telomere lengths

et al. 2007

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Section: Introductionmentioning

confidence: 99%

The higher incidence of squamous cell carcinoma in renal transplant recipients is associated with increased telomere lengths

et al. 2007

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“…Also, patients who undergo renal transplantation require long-term immunosuppression and, as such, they are at risk of a number of skin complications. Studies have shown that these dermatological conditions, including dry skin, can have a considerable impact on the patients' quality of life [22] . Dermatological conditions are common in patients who have undergone renal (and other major organ) transplantations.…”

Section: Kidney Diseasesmentioning

confidence: 99%

The Role of Emollients in the Management of Diseases with Chronic Dry Skin

Proksch

2008

Skin Pharmacol Physiol

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Dry skin is a common skin condition as well as a key aspect of a number of diseases such as atopic dermatitis and psoriasis but also of other diseases and systemic conditions. Dry skin has an impact on the patient in terms of discomfort, pruritus and impaired quality of life. Within the overall treatment regimen for these diseases, the use of emollients to manage dry skin plays a considerable role in managing skin conditions. In atopic dermatitis and psoriasis, emollients help to improve skin condition and to reduce pruritus alongside more potent pharmacological agents. It is important to choose an emollient that not only soothes and rehydrates the skin but also offers numerous other dermatological supporting roles, especially induction of proper epidermal differentiation. This review will explain the role of emollients within the management of diseases with dry skin as a major symptom and the components of an ideal emollient.

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“…However, several studies highlighted an increased risk of developing skin and mucosal lesions in organ transplant patients receiving CspA or FK506 treatment [14], [15]. Under normal condition, re-epithelization of wounds requires keratinocyte migration, proliferation and differentiation.…”

Section: Resultsmentioning

confidence: 99%

T-Plastin Expression Downstream to the Calcineurin/NFAT Pathway Is Involved in Keratinocyte Migration

et al. 2014

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Cutaneous wound healing requires keratinocyte proliferation, migration and differentiation to restore the barrier function of the skin. The calcineurin/nuclear factor of activated-T-cell (NFAT) signaling pathway has been recently shown to be involved in keratinocyte growth, differentiation and migration. It is induced by an increased intracellular calcium rate and its inhibition results in decreased capacities of keratinocytes to migrate. Nevertheless, the link between calcineurin activation and keratinocyte migration remains unknown. Recently, Orai1, a pore subunit of a store-operated calcium channel that favors calcium influx, was shown to play a critical role to control proliferation and migration of basal keratinocytes. Of interest, the actin-bundling T-plastin is crucial in cell motility through cross-linking to actin filament and its synthesis was shown to be induced by calcium influx and regulated by the calcineurin/NFAT pathway in tumor Sezary cells. We investigated herein the role of the calcineurin/NFAT pathway-dependent T-plastin in keratinocyte migration, by quantifying T-plastin expression in keratinocytes and by analyzing their migration under calcineurin inhibition or knockdown of NFAT2 or T-plastin. We did confirm the role of the calcineurin/NFAT pathway in keratinocyte migration as shown by their decreased capacities to migrate after FK506 treatment or siNFAT2 transfection in both scratching and Boyden assays. The expression of NFAT2 and T-plastin in keratinocytes was decreased under FK506 treatment, suggesting that T-plastin plays a role in keratinocyte migration downstream to the calcineurin/NFAT pathway. Accordingly, siRNA knockdown of T-plastin expression also decreased their migration capacities. Actin lamellipodia formation as well as FAK and β6-integrin expression were also significantly decreased after treatment with FK506 or siRNA, reinforcing that NFAT2-dependent T-plastin expression plays a role in keratinocyte migration. These results indicate that T-plastin might be considered as a major actor in the mechanisms underlying calcineurin/NFAT-dependent keratinocyte migration and may explain wound-healing defects observed in patients under calcineurin inhibitor long-term treatment.

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The impact of skin disease following renal transplantation on quality of life

Cited by 79 publications

References 17 publications

The higher incidence of squamous cell carcinoma in renal transplant recipients is associated with increased telomere lengths

The higher incidence of squamous cell carcinoma in renal transplant recipients is associated with increased telomere lengths

The Role of Emollients in the Management of Diseases with Chronic Dry Skin

T-Plastin Expression Downstream to the Calcineurin/NFAT Pathway Is Involved in Keratinocyte Migration

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