The impact of skin hyperpigmentation and hyperchromia on quality of life: A cross-sectional study

Maymone, Mayra B.C.; Neamah, Hind H.; Wirya, Stephen A.; Patzelt, Nicole; Secemsky, Eric A.; Zancanaro, Pedro; Vashi, Neelam A.

doi:10.1016/j.jaad.2017.05.009

Cited by 43 publications

(39 citation statements)

References 4 publications

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“…58 Skin discolouration is a common adverse effect of clofazimine. 59 Skin hyperpigmentation has been associated with poorer perceived quality of life in younger adults (aged <35 years), 60 so this effect is likely to be distressing and stigmatising for adolescents and may lead to decreased adherence and treatment discontinuation.…”

Section: Rifampicin Resistant Tuberculosismentioning

confidence: 99%

Adolescent tuberculosis

Snow

Cruz

Seddon

et al. 2020

The Lancet Child & Adolescent Health

125

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Adolescence is characterised by a dramatic increase in the incidence of tuberculosis, a fact that has been appreciated since the early 20 th century. The majority of the world's adolescents live in low and middle-income countries where tuberculosis remains common, and where they comprise one quarter of the population. Despite this, adolescents have not yet been addressed as a distinct population in tuberculosis policy or within tuberculosis treatment services, and emerging evidence suggests that current models of care do not meet their needs.This article reviews current knowledge about tuberculosis in adolescence with a focus on the management of infection and disease, including HIV co-infection and rifampicin-resistant tuberculosis. Recent progress in vaccine development is outlined and important directions for future research are highlighted. Search strategy and selection criteriaThis was a narrative review of the literature on adolescent tuberculosis, informed by expert opinion and clinical experience. We reviewed the English-and Spanish-language literature for studies on adolescent tuberculosis to identify case series documenting clinical presentation and treatment outcomes. We searched PubMed with the following string on 19August 2019: ('tuberculosis'[Title]) AND ('adolescent'[TIAB]). The search returned 210 results, of which 11 were eligible for inclusion (Table 1), and we identified three additional studies from reference lists, for a total of 14 studies. Studies reporting solely on prevalence or where data from adolescents was aggregated with those of younger children or adults were excluded. Data were extracted regarding major site(s) of disease, percent of adolescents with microbiologic confirmation, adverse drug reactions, and final treatment outcomes.

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Section: Rifampicin Resistant Tuberculosismentioning

confidence: 99%

Adolescent tuberculosis

Snow

Cruz

Seddon

et al. 2020

The Lancet Child & Adolescent Health

125

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“…Due to psychosocial implications, hyperpigmentary disorders, such as melasma, have a profound impact on a patient's quality of life (Maymone et al, 2017). Also, due to frequent relapses, the treatment of melasma is frustrating for patients and challenging for physicians.…”

Section: Discussionmentioning

confidence: 99%

“…The significance of those triggering factors is underscored by the fact that melasma mainly affects adult women with darker complexions (Fitzpatrick skin types IIIeV) who live in areas with intense sun exposure (Handel et al, 2014;Sheth and Pandya, 2011). The emotional and psychological effects of this disorder can severely impact a patient's quality of life (Maymone et al, 2017). This distressing situation is exacerbated by the fact that treatment of melasma can be challenging because long-term therapy is often required and reoccurrence is common.…”

Section: Introductionmentioning

confidence: 99%

Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma

Arrowitz¹,

Schoelermann

Mann

et al. 2019

Journal of Investigative Dermatology

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Melasma is a pigmentary disorder characterized by hyperpigmented patchy skin in sun-exposed areas, especially the face. Treatment of melasma can be challenging because long-term therapy is required, reoccurrence is common, and existing therapies are insufficient and unsatisfactory. To investigate new treatment options, we performed an exploratory double-blinded, randomized split-face study to assess the efficacy of the tyrosinase inhibitor Thiamidol compared to hydroquinone in women with mild to moderate melasma. After 12 weeks, modified Melasma Area and Severity Index scores significantly improved on both the Thiamidol-treated and the hydroquinone-treated sides of the face. Additionally, Thiamidol treatment improved modified Melasma Area and Severity Index scores significantly better than hydroquinone, and more subjects improved following treatment with Thiamidol (79%) compared with hydroquinone (61%). During treatment, no subjects displayed worsening of modified Melasma Area and Severity Index scores on the Thiamidol-treated side, while approximately 10% of the subjects showed a worsening of modified Melasma Area and Severity Index scores on the hydroquinone-treated side. All subjects routinely used sunscreens and consistent results were obtained in low and in high UV ambient conditions. Subjects rated the efficacy of the Thiamidol formulation significantly better with regard to overall decreased intensity of dark spots and their overall appearance throughout the study. Thiamidol was well-tolerated and well-perceived and represents an effective agent to reduce hyperpigmentation.

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“…5 In a study of 419 patients, those with post-inflammatory hyperpigmentation had higher scores on the Dermatology Life Quality Index (DLQI) survey, which indicates poorer quality of life, when compared to patients with other disorders of hyperpigmentation. 12 Additionally, the study demonstrated that DLQI scores were higher in women and those younger than 35 years of age. Having a graduate level education was associated with significantly lower DLQI scores, showing that patients with lower education level had a more negative impact on quality of life.…”

Section: Dupilumab Improves Atopic Dermatitis and Post-inflammatory Hmentioning

confidence: 85%

Dupilumab Improves Atopic Dermatitis and Post-Inflammatory Hyperpigmentation in Patient With Skin of Color

Grayson¹,

Heath²

2020

JDD

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Atopic dermatitis, a chronic inflammatory condition, accounts for numerous dermatology visits for patients with skin of color. The inflammatory process often leads to post-inflammatory hyperpigmentation, especially in patients with skin of color, which may negatively impact quality of life. We present a case that demonstrates clinical improvement of atopic dermatitis, post inflammatory hyperpigmentation, and lightening of pigmentation in clinically non-lesional areas after initiation of dupilumab. Lightening of the patient's skin even in areas that previously appeared clinically normal supports the scientific evidence that non-lesional skin in those with atopic dermatitis is often subclinically involved. For skin of color patients, aggressive treatment with duplimab may accelerate the return of the patient's overall normal skin tone.

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The impact of skin hyperpigmentation and hyperchromia on quality of life: A cross-sectional study

Cited by 43 publications

References 4 publications

Adolescent tuberculosis

Adolescent tuberculosis

Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma

Dupilumab Improves Atopic Dermatitis and Post-Inflammatory Hyperpigmentation in Patient With Skin of Color

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