The Impact of Smoking on Microbiota: A Narrative Review

Cicchinelli, Sara; Rosa, Federico; Manca, Federica; Zanza, Christian; Ojetti, Veronica; Covino, Marcello; Candelli, Marcello; Gasbarrini, Antonio; Franceschi, Francesco; Piccioni, Andrea

doi:10.3390/biomedicines11041144

Cited by 14 publications

(7 citation statements)

References 82 publications

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“…Bacteriodes vulgatus, Eubacterium rectale), but these results were not found in our study (Shen et al, 2022). Cigarette smoking has been consistently linked to alterations in the gut microbiome among adults (Cicchinelli et al, 2023). The impact of maternal smoking during gestation on the prenatal and perinatal gut environment is also suspected.…”

Section: Impact Of Tobacco Smoke Exposure and Mercury On Gut Microbio...contrasting

confidence: 78%

Influence of perinatal and childhood exposure to tobacco and mercury in children’s gut microbiota

Pérez-Castro,

D’Auria,

Llambrich

et al. 2024

Front. Microbiol.

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BackgroundEarly life determinants of the development of gut microbiome composition in infants have been widely investigated; however, if early life pollutant exposures, such as tobacco or mercury, have a persistent influence on the gut microbial community, its stabilization at later childhood remains largely unknown.ObjectiveIn this exposome-wide study, we aimed at identifying the contribution of exposure to tobacco and mercury from the prenatal period to childhood, to individual differences in the fecal microbiome composition of 7-year-old children, considering co-exposure to a width of established lifestyle and clinical determinants.MethodsGut microbiome was studied by 16S rRNA amplicon sequencing in 151 children at the genus level. Exposure to tobacco was quantified during pregnancy through questionnaire (active tobacco consumption, second-hand smoking -SHS) and biomonitoring (urinary cotinine) at 4 years (urinary cotinine, SHS) and 7 years (SHS). Exposure to mercury was quantified during pregnancy (cord blood) and at 4 years (hair). Forty nine other potential environmental determinants (12 at pregnancy/birth/infancy, 15 at 4 years and 22 at 7 years, such as diet, demographics, quality of living/social environment, and clinical records) were registered. We used multiple models to determine microbiome associations with pollutants including multi-determinant multivariate analysis of variance and linear correlations (wUnifrac, Bray-Curtis and Aitchison ß-diversity distances), single-pollutant permutational multivariate analysis of variance adjusting for co-variates (Aitchison), and multivariable association model with single taxa (MaAsLin2; genus). Sensitivity analysis was performed including genetic data in a subset of 107 children.ResultsActive smoking in pregnancy was systematically associated with microbiome composition and ß-diversity (R2 2–4%, p < 0.05, Aitchison), independently of other co-determinants. However, in the adjusted single pollutant models (PERMANOVA), we did not find any significant association. An increased relative abundance of Dorea and decreased relative abundance of Akkermansia were associated with smoking during pregnancy (q < 0.05).DiscussionOur findings suggest a long-term sustainable effect of prenatal tobacco exposure on the children’s gut microbiota. This effect was not found for mercury exposure or tobacco exposure during childhood. Assessing the role of these exposures on the children’s microbiota, considering multiple environmental factors, should be further investigated.

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Section: Impact Of Tobacco Smoke Exposure and Mercury On Gut Microbio...contrasting

confidence: 78%

Influence of perinatal and childhood exposure to tobacco and mercury in children’s gut microbiota

Pérez-Castro,

D’Auria,

Llambrich

et al. 2024

Front. Microbiol.

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“…It is now well known how lifestyle (e.g., smoking) affects the composition of the gut microbiota [64], and again one of the reasons we have devoted ourselves to this topic is precisely to thoroughly investigate this habit, which is as widespread in the world as coffee drinking.…”

Section: Discussionmentioning

confidence: 99%

Coffee and Microbiota: A Narrative Review

Rosa,

Marigliano,

Mannucci

et al. 2024

CIMB

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Coffee is one of the most widely consumed beverages in the world, which has important repercussions on the health of the individual, mainly because of certain compounds it contains. Coffee consumption exerts significant influences on the entire body, including the gastrointestinal tract, where a central role is played by the gut microbiota. Dysbiosis in the gut microbiota is implicated in the occurrence of numerous diseases, and knowledge of the microbiota has proven to be of fundamental importance for the development of new therapeutic strategies. In this narrative review, we thoroughly investigated the link between coffee consumption and its effects on the gut microbiota and the ensuing consequences on human health. We have selected the most significant articles published on this very interesting link, with the aim of elucidating the latest evidence about the relationship between coffee consumption, its repercussions on the composition of the gut microbiota, and human health. Based on the various studies carried out in both humans and animal models, it has emerged that coffee consumption is associated with changes in the gut microbiota, although further research is needed to understand more about this link and the repercussions for the whole organism.

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“…The airway microbiome is constantly affected by numerous factors that challenge the respiratory health including host genetics, diet, alcohol, physical activity, drugs, exposure to toxicants such as smoke, biofuel and pollutants and oral health (Cicchinelli et al., 2023; Du et al., 2023; Lim et al., 2016; Xue et al., 2020). Here, we focus on cigarette smoking and oral health, which are closely related to each other and to COPD risk, development and progression.…”

Section: Smoking and Oral Health Shape The Airway Microbiome Through ...mentioning

confidence: 99%

“…Cigarette smoking influences the composition of the airway microbiota due to, among others, exposure to bacterial pathogens contained in the cigarettes themselves; impaired antimicrobial defences due to the immunosuppresive nature of tobacco; physiological changes in the airway microenvironment that facilitate the outgrowth of anaerobes through reduced oxygen, acid production and pH shift (Huang & Shi, 2019). Smoking is also a major environmental factor influencing the composition of the oral and subgingival microbiota, and smokers have oral dysbiosis with a highly diverse, pathogen‐rich, commensal‐poor and anaerobic oral microbiome (Cicchinelli et al., 2023; Huang & Shi, 2019). Smoking effects on the oral microbiome have an impact on the lower airway dysbiosis through the oral–lung axis and, therefore, on respiratory health.…”

Section: Smoking and Oral Health Shape The Airway Microbiome Through ...mentioning

confidence: 99%

Environmental exposures, the oral–lung axis and respiratory health: The airway microbiome goes on stage for the personalized management of human lung function

Garmendia,

Cebollero‐Rivas

2024

Microbial Biotechnology

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The human respiratory system is constantly exposed to environmental stimuli, sometimes including toxicants, which can trigger dysregulated lung immune responses that lead to respiratory symptoms, impaired lung function and airway diseases. Evidence supports that the microbiome in the lungs has an indispensable role in respiratory health and disease, acting as a local gatekeeper that mediates the interaction between the environmental cues and respiratory health. Moreover, the microbiome in the lungs is intimately intertwined with the oral microbiome through the oral–lung axis. Here, we discuss the intricate three‐way relationship between (i) cigarette smoking, which has strong effects on the microbial community structure of the lung; (ii) microbiome dysbiosis and disease in the oral cavity; and (iii) microbiome dysbiosis in the lung and its causal role in patients suffering chronic obstructive pulmonary disease (COPD), a leading cause of morbidity and mortality worldwide. We highlight exciting outcomes arising from recently established interactions in the airway between environmental exposures, microbiome, metabolites–functional attributes and the host, as well as how these associations have the potential to predict the respiratory health status of the host through an airway microbiome health index. For completion, we argue that incorporating (synthetic) microbial community ecology in our contemporary understanding of lung disease presents challenges and also rises novel opportunities to exploit the oral–lung axis and its microbiome towards innovative airway disease diagnostics, prognostics, patient stratification and microbiota‐targeted clinical interventions in the context of current therapies.

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The Impact of Smoking on Microbiota: A Narrative Review

Cited by 14 publications

References 82 publications

Influence of perinatal and childhood exposure to tobacco and mercury in children’s gut microbiota

Influence of perinatal and childhood exposure to tobacco and mercury in children’s gut microbiota

Coffee and Microbiota: A Narrative Review

Environmental exposures, the oral–lung axis and respiratory health: The airway microbiome goes on stage for the personalized management of human lung function

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