The Impact of Stress, Microbial Dysbiosis, and Inflammation on Necrotizing Enterocolitis

Yeramilli, Venkata; Cheddadi, Riadh; Benjamin, Heather; Martin, Colin

doi:10.3390/microorganisms11092206

Cited by 5 publications

(2 citation statements)

References 105 publications

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“…Various bacteria have been isolated from fecal cultures of neonates with NEC, such as E. coli, Klebsiella, Enterobacter, Pseudomonas, Salmonella, Clostridioides difficile, coagulase-negative Staphylococci, etc. [90,91]. In the last decade, the important role of probiotics and prebiotics in reducing the incidence of NEC in experimental models and in clinical trials has been established.…”

Section: The Role Of Intestinal Microbiotamentioning

confidence: 99%

Gut Microbiota and Immune System in Necrotizing Enterocolitis and Related Sepsis

Jirillo,

Topi,

Charitos

et al. 2024

Gastrointestinal Disorders

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A severe condition of sepsis can be a complication of necrotizing enterocolitis (NEC), which can occur in premature infants and becomes a medical challenge in the neonatal intensive care unit (NICU). It is a multifactorial intestinal disease (can affect both the small and large intestine) that can lead to ischemia of the intestinal tissues that evolves into acute organ necrosis. One of these factors is that different types of nutrition can influence the onset or the progression of the disease. Cow-milk-based infant formulas have been shown to cause it in premature infants more frequently than human milk. Recently, nutrition has been shown to be beneficial after surgery. Several issues still under study, such as the pathogenesis and the insufficient and often difficult therapeutic approach, as well as the lack of a common and effective prevention strategy, make this disease an enigma in daily clinical practice. Recent studies outlined the emerging role of the host immune system and resident gut microbiota, showing their close connection in NEC pathophysiology. In its initial stages, broad-spectrum antibiotics, bowel rest, and breastfeeding are currently used, as well as probiotics to help the development of the intestinal microbiota and its eubiosis. This paper aims to present the current knowledge and potential fields of research in NEC pathophysiology and therapeutic assessment.

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Section: The Role Of Intestinal Microbiotamentioning

confidence: 99%

Gut Microbiota and Immune System in Necrotizing Enterocolitis and Related Sepsis

Jirillo,

Topi,

Charitos

et al. 2024

Gastrointestinal Disorders

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“…Analogously, the rudimentary, less diverse microbiota in early infancy can be likened to a solid foundation for a building. Should this foundation be flawed, any structure constructed upon it is predisposed to instability and eventual deterioration [72][73][74]. Considering this perspective, particular microbiome profiles can be directly associated with specific diseases.…”

Section: Interpreting Varied Microbiome Profilesmentioning

confidence: 99%

From Mother to Infant, from Placenta to Gut: Understanding Varied Microbiome Profiles in Neonates

Cheddadi,

Yeramilli,

Martin

2023

Metabolites

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The field of human microbiome and gut microbial diversity research has witnessed a profound transformation, driven by advances in omics technologies. These advancements have unveiled essential connections between microbiome alterations and severe conditions, prompting the development of new frameworks through epidemiological studies. Traditionally, it was believed that each individual harbored unique microbial communities acquired early in life, evolving over the course of their lifetime, with little acknowledgment of any prenatal microbial development, but recent research challenges this belief. The neonatal microbiome’s onset, influenced by factors like delivery mode and maternal health, remains a subject of intense debate, hinting at potential intrauterine microbial processes. In-depth research reveals associations between microbiome profiles and specific health outcomes, ranging from obesity to neurodevelopmental disorders. Understanding these diverse microbiome profiles is essential for unraveling the intricate relationships between the microbiome and health outcomes.

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Can Postbiotics Represent a New Strategy for NEC?

Giannì,

Morniroli,

Mosca

et al. 2024

Advances in Experimental Medicine and Biology

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The Impact of Stress, Microbial Dysbiosis, and Inflammation on Necrotizing Enterocolitis

Cited by 5 publications

References 105 publications

Gut Microbiota and Immune System in Necrotizing Enterocolitis and Related Sepsis

Gut Microbiota and Immune System in Necrotizing Enterocolitis and Related Sepsis

From Mother to Infant, from Placenta to Gut: Understanding Varied Microbiome Profiles in Neonates

Can Postbiotics Represent a New Strategy for NEC?

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