The impact of stroke on cognitive processing — A prospective event-related potential study

Stahlhut, Leandra; Grotemeyer, Karl-Heinz; Husstedt, I. W.; Evers, Stefan

doi:10.1016/j.jns.2014.02.006

Cited by 9 publications

(5 citation statements)

References 84 publications

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“…Interestingly, ERP can be valuable in the diagnosis of cognitive impairment and can track the cognitive changes during the follow-up in stroke patients. 38 Recently, Non-Invasive Brain Stimulation (NIBS) techniques have been proposed as support of standard cognitive and motor rehabilitation. 39 , 40 rTMS and transcranial Direct Current Stimulation (tDCS) are the most used NIBS techniques in rehabilitation.…”

Section: Discussionmentioning

confidence: 99%

The role of repetitive transcranial magnetic stimulation in the treatment of cognitive impairment in stroke patients: A systematic review and meta-analysis

Liu

Bao

Bai³

et al. 2021

Science Progress

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Stroke is a global health problem, and survivors of a stroke often suffer from cognitive impairment, which has an essential impact on the rehabilitation of various functions. Repetitive Transcranial Magnetic Stimulation (rTMS) has been widely used in the rehabilitation treatment of stroke patients. There are many investigations into how rTMS impacts motor dysfunction, speech dysfunction and swallowing dysfunction after stroke, but the analysis of rehabilitation effect on stroke patients with cognitive dysfunction is lacking. The purpose of this study was to analyze the effect of different rTMS related therapies on cognitive impairment and to evaluate its clinical effect on cognitive rehabilitation after stroke. Four databases including PubMed, EMBASE, MEDLINE and the Cochrane Library, were searched and a total of 2754 papers were collected. Two reviewers independently completed a review of all papers’ titles and abstracts, screened out the documents that met the criteria, and carried out data extraction, quality assessment, and data analysis. A total of six studies with 197 patients were included. Three studies used the Mini-Mental Status Examination (MMSE) scale to evaluate the cognitive function with a mean effect size of 1.89 (95% CI = −3.08–6.86). Two studies used the Loewenstein Occupational Therapy of Cognitive Assessment (LOTCA) scale with the mean effect size of 1.64 (95% CI = −7.65–10.93). These studies were evaluated separately. Our article provides that rTMS has a positive effect on improving the cognitive ability of stroke patients, but the evidence is still limited, and further large-scale studies are needed to explore the optimal stimulus parameters.

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Section: Discussionmentioning

confidence: 99%

The role of repetitive transcranial magnetic stimulation in the treatment of cognitive impairment in stroke patients: A systematic review and meta-analysis

Liu

Bao

Bai³

et al. 2021

Science Progress

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“…In previous reports, the authors measured P300 latencies at Pz or Cz (Trinka et al, 2000 ; Alonso-Prieto et al, 2002 ; Yamagata et al, 2004 ; Stahlhut et al, 2014 ) while in our study we used a finer setup and ERP latencies has been computed at F3, F4, F7, F8, C3, C4, P3, P4, T3, T4. No significant difference has been observed in P300 latency values measured on right or left hemisphere's electrodes.…”

Section: Discussionmentioning

confidence: 93%

“…Stahlhut et al ( 2014 ) reported ERP data of 563 stroke patients within 4 weeks, after 12 and 24 months from the ischemic event. In this paper, a lengthened P300 latency at baseline in 51% of the patients, similar for left or right lesions, was reported with a significant improvement after 24 months (about 20 ms), similar for left and right hemispheric infarction.…”

Section: Discussionmentioning

confidence: 99%

“…Event Related Potentials (ERP) are a reproducible electrophysiological response to an external stimulus (visual or auditory), representing the brain activity associated with various cognitive processes such as selective attention, memory, or decision making. Interestingly, ERP can be valuable in the diagnosis of cognitive impairment and are able to track the cognitive changes during the follow-up in stroke patients (Trinka et al, 2000 ; Alonso-Prieto et al, 2002 ; Yamagata et al, 2004 ; Stahlhut et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

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Cognitive and Neurophysiological Effects of Non-invasive Brain Stimulation in Stroke Patients after Motor Rehabilitation

D’Agata

Peila

Cicerale

et al. 2016

Front. Behav. Neurosci.

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The primary aim of this study was to evaluate and compare the effectiveness of two specific Non-Invasive Brain Stimulation (NIBS) paradigms, the repetitive Transcranial Magnetic Stimulation (rTMS), and transcranial Direct Current Stimulation (tDCS), in the upper limb rehabilitation of patients with stroke. Short and long term outcomes (after 3 and 6 months, respectively) were evaluated. We measured, at multiple time points, the manual dexterity using a validated clinical scale (ARAT), electroencephalography auditory event related potentials, and neuropsychological performances in patients with chronic stroke of middle severity. Thirty four patients were enrolled and randomized. The intervention group was treated with a NIBS protocol longer than usual, applying a second cycle of stimulation, after a washout period, using different techniques in the two cycles (rTMS/tDCS). We compared the results with a control group treated with sham stimulation. We split the data analysis into three studies. In this first study we examined if a cumulative effect was clinically visible. In the second study we compared the effects of the two techniques. In the third study we explored if patients with minor cognitive impairment have most benefit from the treatment and if cognitive and motor outcomes were correlated. We found that the impairment in some cognitive domains cannot be considered an exclusion criterion for rehabilitation with NIBS. ERP improved, related to cognitive and attentional processes after stimulation on the motor cortex, but transitorily. This effect could be linked to the restoration of hemispheric balance or by the effects of distant connections. In our study the effects of the two NIBS were comparable, with some advantages using tDCS vs. rTMS in stroke rehabilitation. Finally we found that more than one cycle (2–4 weeks), spaced out by washout periods, should be used, only in responder patients, to obtain clinical relevant results.

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“…The main action of the piracetam is mainly unidentified but piracetam was frequently thought to adapt cholinergic receptors in the hippocampus to amplify the special effects of acetylcholine, which is well-known for advancing memory as it is profoundly implicated with the programming of novel memories [21].…”

Section: Discussionmentioning

confidence: 99%

Modulation Effects of Piracetam and Ginkgo Biloba on the Cognitive and Working Memory Functions: Psychometric Study

Al-Kuraishy¹,

Al-Gareeb²,

Albuhadilly³

et al. 2014

J Neurol Neurophysiol

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Extracts of ginkgo biloba have been broadly prescribed toward advance symptoms of cognitive dysfunction ranging in severity from mild memory loss to dementia also; in delaying the development of dementia; ginkgo biloba has been encouraged commercially as a smart medicine to augment the brain function of healthy people. Piracetam is a no tropic remedy correlated to inhibitory γ-aminobutyric acid (GABA) neurotransmitter. Piracetam may be the initial agent acting on cognitive function without sedation. Thirty subjects (30 males) arbitrarily choose as of medical college students. The contributors were allowable to perform mutually on the psychomotor performance device tester and the computerized n-back test (working memory task) to obtain knowledge from those tests sooner than the commencing of the examination. All psychometric response time and working memory test parameters calculated previous to the experimental research, so the identical volunteers considered as control and through four days of receiving the ginkgo biloba 60mg/day (trunature GSL),piracetam 800 mg/day (neutrophil) or both drugs so the enrolled participants divided into three groups .Group A take ginkgo biloba, group B take piracetam and group C take piracetam and ginkgo biloba.Piracetam significantly improve cognitive and working memory at all levels P<0.05 while it showed insignificant effects on psychometric reaction time parameters except it ameliorate the total reaction time (TRT) P <0.05. The differential effects of ginkgo biloba showed significant effects on psychometric reaction time and cognitive central Integrity P<0.05 and insignificant effects on working memory accuracy except at level І-Back where it produced significant effects P<0.05. Combined effects of ginko biloba and piracetam on psychomotor performances, cognitive function and working memory produced significant effects P <0.05.Conclusion: Combined effects of piracetam and ginkgo biloba produced more significant effects than either ginkgo biloba or piracetam alone on cognitive function and working memory.

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The impact of stroke on cognitive processing — A prospective event-related potential study

Cited by 9 publications

References 84 publications

The role of repetitive transcranial magnetic stimulation in the treatment of cognitive impairment in stroke patients: A systematic review and meta-analysis

The role of repetitive transcranial magnetic stimulation in the treatment of cognitive impairment in stroke patients: A systematic review and meta-analysis

Cognitive and Neurophysiological Effects of Non-invasive Brain Stimulation in Stroke Patients after Motor Rehabilitation

Modulation Effects of Piracetam and Ginkgo Biloba on the Cognitive and Working Memory Functions: Psychometric Study

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