The Impact of Tamsulosin Oral Controlled Absorption System (OCAS) on Nocturia and the Quality of Sleep: Preliminary Results of a Pilot Study

Djavan, Bob; Milani, Shirin; Davies, J.G.; Bolodeoku, John

doi:10.1016/j.eursup.2004.12.001

Cited by 74 publications

(45 citation statements)

References 22 publications

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“…Multiple agents including the alpha blockers, anticholinergics, and desmopressin agonists have been used in the medical management of nocturia. [5][6][7][8] As of this date, we are unaware of studies examining the use of these agents in patients who have had prostatectomy for PCa and subsequently have either de-novo or ongoing nocturia and urinary bother. Whether the effect of these medications is similar to or entirely different from the effect seen in patients with a native urinary tract would be informative both from a clinical and pathophysiologic perspective.…”

Section: Discussionmentioning

confidence: 97%

“…4 While prostatic obstruction likely plays a role in the development of nocturia, a more complex picture of the etiology is evident both from clinical experience and interventional trials. [5][6][7][8] For example, decreased time spent in delta wave sleep, decreased renal concentrating ability, age-related detrusor instability, and mechanical obstruction from the prostate all likely contribute to nocturia. 9,10 Related to this, as our understanding of the causes of nocturia and its impact on sleep cycles has evolved, so have our interventional options and medical regimens to alleviate the mechanical obstruction of an obtrusive prostate.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Robot-Assisted Laparoscopic Prostatectomy on Nocturia

Hutchinson

Thiel

Tavlarides

et al. 2012

Journal of Endourology

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

The Effect of Robot-Assisted Laparoscopic Prostatectomy on Nocturia

Hutchinson

Thiel

Tavlarides

et al. 2012

Journal of Endourology

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“…The fact that we have seen what may be a similar salutary effect in what is essentially random sampling of blood glucose without control over time from last meal suggests to us that this effect is likely to be real and probably quite robust. Our measure of sleep, FUSP, has been used in many urologic studies, including studies of desmopressin [34], alpha blockers [35], and anticholinergics [36], though it has not been commonly employed in sleep research per se. We have previously shown in other studies that, at baseline, longer time to initial void is associated cross-sectionally with better quality and deeper sleep [11] as well as, longitudinally, with longer duration of sleep [12].…”

Section: Discussionmentioning

confidence: 99%

Delaying time to first nocturnal void may have beneficial effects on reducing blood glucose levels

et al. 2016

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Experimental studies disrupting sleep and epidemiologic studies of short sleep durations indicate the importance of deeper and longer sleep for cardiometabolic health. We examined the potential beneficial effects of lengthening the first uninterrupted sleep period (FUSP) on blood glucose. Long-term data (≥3 months of treatment) were derived from three clinical trials, testing low-dose (10-100 µg) melt formulations of desmopressin in 841 male and female nocturia patients (90 % of which had nocturnal polyuria). We performed post hoc multiple regression with non-fasting blood glucose as dependent variable and the following potential covariates/factors: time-averaged change of FUSP since baseline, age, gender, race, ethnicity, baseline glucose, baseline weight, change in weight, patient metabolic status (normal, metabolic syndrome, type II diabetes), dose, follow-up interval, and time of random glucose sampling. Increases in FUSP resulted in statistically significant reductions in blood glucose (p = 0.0131), even after controlling for all remaining covariates. Per hour increase in time to first void was associated with glucose decreases of 1.6 mg/dL. This association was more pronounced in patients with increased baseline glucose levels (test of baseline glucose by FUSP change interaction: p < 0.0001). Next to FUSP change, other statistically significant confounding factors/covariates also associated with glucose changes were gender, ethnicity, metabolic subgroup, and baseline glucose. These analyses indicate that delaying time to first void may have beneficial effects on reducing blood glucose in nocturia patients. These data are among the first to suggest that improving sleep may have salutary effects on a cardiometabolic measure.

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“…After such adjustments, WW was about as effective in reducing nocturia as an α -blocker, whereas TUMT and particularly TURP were significantly more effective. The lack of statistical differentiation between WW and α -blockers does not necessarily show an ineffectiveness of the latter, but might relate to differences between WW and placebo-treatment and/or to the fact that the beneficial effect of α -blockers on nocturia has not been found in all studies [17][18][19][20]. Interestingly, the adjusted advantage of TUMT and TURP relative to an α -blocker corresponded to once and twice, respectively, the advantage that terazosin or doxazosin had shown relative to placebo in 1-and 4-year studies, respectively [6,14].…”

Section: Resultsmentioning

confidence: 99%

“…They showed beneficial effects on nocturia for many α -blockers including alfuzosin (both the immediate and the extended-release formulations) [11,12], the immediate-release formulation of doxazosin [13,14], the modified-release formulation of tamsulosin [15], and the immediate-release formulation of terazosin [6,16]. However, some studies detected no significant improvements of nocturia on α -blocker treatment relative to placebo, which might have been due to small sample sizes in some cases [17][18][19][20]. Recent data suggest that muscarinic antagonists can also reduce nocturia in men with LUTS/BPH and overactive bladder symptoms [21].…”

Section: Introductionmentioning

confidence: 99%

The role of nocturia in the quality of life of men with lower urinary tract symptoms

Dijk¹,

Wijkstra²,

Debruyne

et al. 2010

BJU International

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PATIENTS AND METHODSWe retrospectively analysed using multiple regression a large single-centre database of patients receiving routine care for treatment-associated alterations of symptoms and HRQL (assessed at baseline, 2611 men) and 6-12 months after initiation of treatment (1258 men). RESULTSAmong the symptoms assessed using the International Prostate Symptom Score, nocturia (together with urgency and weak stream) had the strongest correlation with HRQL at baseline and after treatment. Watchful waiting, α -blockers, TUMT and TURP reduced nocturia episodes by a mean ( SD ) of 7 (53)%, 17 (40)%, 32 (47)% and 75 (23)%, respectively. The treatmentassociated improvements in nocturia (together with those of weak stream) had the strongest association with those of HRQL. CONCLUSIONSWe conclude that among all LUTS assessed in the IPSS, nocturia has one of the strongest associations with HRQL, and that treatmentassociated improvements in nocturia contribute considerably to overall improvements in HRQL. KEYWORDSBPH, nocturia, quality of life, TURP, transurethral microwave thermotherapy, α 1 -adrenoceptor antagonist Study Type -Symptom prevalence (retrospective cohort) Level of Evidence 2b OBJECTIVESTo determine the role of treatmentassociated improvement in nocturia in health-related quality of life (HRQL) in patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia, and secondarily to confirm the role of nocturia in HRQL at baseline and to compare the effects of watchful waiting, transurethral microwave treatment (TUMT) and transurethral resection of the prostate (TURP) to those of α 1 -adrenoceptor antagonists ( α -blockers) on nocturia.

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The Impact of Tamsulosin Oral Controlled Absorption System (OCAS) on Nocturia and the Quality of Sleep: Preliminary Results of a Pilot Study

Cited by 74 publications

References 22 publications

The Effect of Robot-Assisted Laparoscopic Prostatectomy on Nocturia

The Effect of Robot-Assisted Laparoscopic Prostatectomy on Nocturia

Delaying time to first nocturnal void may have beneficial effects on reducing blood glucose levels

The role of nocturia in the quality of life of men with lower urinary tract symptoms

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