The ergonomics on body pressure distribution of latex product design is the future trend in bedding product design. The numerical simulation of latex pillow compression performance is critical for the optimal design of bedding products. This paper reports the use of the finite element method to simulate the compression performance of latex foam and the design of latex pillows based on the pressure distribution and displacement changes of the human pillow system. The compression performance, shear performance and tensile performance of the latex foam are tested, and the stress and strain images of three mechanical experiments are obtained. Combined with the experimental results, three methods of ‘hyper foam test data, hyper foam model parameter method and low-density foam method’ were used to perform uniaxial compression simulation on bedding latex foam using the finite element software ABAQUS. The simulation results and experimental values were fitted and analyzed. The analysis found that the low-density foam simulation method has the largest R2, which is 0.9871, and the simulation result is the most accurate. The optimal simulation method was selected to simulate the dynamic pressure changes and cervical displacement of the human head and latex pillow models, as well as the simulation experiments with latex pillows of different heights. The curve is fitted to obtain the second-order polynomial equations of pressure and cervical socket displacement. In contrast, it can be concluded that latex pillow products with a neck height of 100 mm are better for the supine position of younger adult women in China.