This article investigates the macroeconomic effects of unionization in a Schumpeterian growth model with an endogenous product market structure and a unionized labor market. The endogeneity of the market structure and the trade unionism of the labor market interact and jointly determine the equilibrium unemployment, firm size, number of firms, economic growth, and distribution of income between workers and firms. We show that unionization governs the distribution of income between workers and firms and the unemployment rate, but it does not give rise to any growth effect on the economy. In addition, unionization discourages potential entrants and hence decreases the equilibrium number of firms. These results echo the empirical observation in the sense that unionization raises unemployment and alters the distribution of income between workers and firms, but it does not give rise to a significant, real impact on the firms investment and the economy-wide growth. It should be noted that as argued by Freeman (2007), this evidence has recently turned out to be fragile. The unemployment effect of collective bargaining appears to be contingent upon other institutional and policy factors that need to be clarified to provide robust policy advice. The estimated coefficients on labor institutions become statistically insignificant with modest changes in the measures of institutions, countries covered, and time period. Models that cover more years, countries, and measures than the early studies provide little support for those who advocate the conventional deregulation of labor markets (Baker et al., 2005). This valuable information was provided to us by an anonymous referee, to whom we are grateful.