The impact of the IL-1β, IL-1Ra, IL-2, IL-6 and IL-10 gene polymorphisms on the development of Behcet's disease and their association with the phenotype

Barış, Savaş; Akyürek, Ömer; Dursun, Ahmet; Akyol, Mesut

doi:10.1016/j.medcle.2015.09.007

Cited by 4 publications

(7 citation statements)

References 18 publications

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“…In this study, we detected the following IL-1Ra alleles: a1 (70.1%) (p=0. 26 Table 4. Post-power analysis was 49% for the skin involvement variable.…”

Section: Resultsmentioning

confidence: 99%

“…In previously studies conducted on Turkish population, it was reported that the frequency of the IL-1Ra genotype and allele was not different between patients with BD and healthy controls (25)(26)(27) Ethics Committee Approval: Ethics committee approval was received for this study from the ethics committee of Gaziosmanpaşa University 15-KAEK-142.…”

Section: Discussionmentioning

confidence: 99%

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Investigation of the role of interleukin 1 receptor antagonist VNTR variant on the Behçet's disease

Dursun¹,

Demir²,

Karakuş³

et al. 2017

Eur J Rheumatol

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Objective: Behçet's disease (BD), a chronic multisystem inflammatory disorder, is mainly characterized by relapsing periods of a wide range of clinical symptoms. Several cytokine genes may play important roles in the pathogenesis of BD. Therefore, interleukin-1 receptor antagonist (IL-1Ra) gene 86bp variable number tandem repeat (VNTR) variant was investigated in patients with BD in a Turkish population. Material and methods: One hundred nine patients (60 females, 49 males; the mean age±standard deviation [SD] was 36.56±9.571 years) with BD and one hundred healthy individuals (54 females, 46 males; the mean age±SD was 36.64±2.294 years) were examined in the study. For genotyping, polymerase chain reaction-restriction fragment length polymorphism analysis was employed. Data were analyzed using Statistical Package for Social Sciences (SPSS) 22.0 (p<0.05). Results: The genotype distribution and allele frequencies of the IL-1Ra VNTR variant did not differ significantly between the patients and the controls (p>0.05). The frequency of the a1/a1, a1/a2 genotypes and a1, a2 alleles were the most common both in patients and healthy controls (p=0.37, p=0.26, and p=0.53, respectively). Also, no statistically significant difference was found between the IL-1Ra VNTR variant genotypes and clinical characteristics (p>0.05). Conclusion:The results of this study do not support an association between the IL-1Ra VNTR variant and the risk of BD in a Turkish population. However, further studies of this variant with larger sample sizes and different ethnicities are required for confirmation.

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“…In this study, we detected the following IL-1Ra alleles: a1 (70.1%) (p=0. 26 Table 4. Post-power analysis was 49% for the skin involvement variable.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Investigation of the role of interleukin 1 receptor antagonist VNTR variant on the Behçet's disease

Dursun¹,

Demir²,

Karakuş³

et al. 2017

Eur J Rheumatol

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“…Proinflamatuvar sitokinlerden biri olan IL-2, TH1 ve TH2 immun yanıtta rol oynayan önemli sitokinlerden biri olup, -330 promoter bölgesindeki polimorfizmi hastalık sitokin ilişkisinin araştırıldığı en yaygın polimorfizmlerden birisidir (4). IL-2 -330 gen polimorfizmi ile çeşitli hastalıklar arasındaki ilişkiyi araştıran çok sayıdaki çalışmaya rağmen (20)(21)(22) literatürde bu sitokin polimorfizminin hepatit B ve C enfeksiyonlarındaki rolünü araştıran sınırlı sayıda çalışma bulunmaktadır (23,24).…”

Section: Discussionunclassified

“…IL-2 -330 gen polimorfizmi son yıllarda en yaygın araştırılan konulardan biri olup, bu gen polimorfizmi ile hastalık ilişkisinin araştırıldığı çok sayıda çalışma bulunmaktadır (20)(21)(22). Bununla birlikte literatürde bu sitokin polimorfizminin kronik hepatit B ve C hastalığının immunopatogenezindeki rolünü belirleyen oldukça az sayıda çalışmaya rastlanılmıştır.…”

Section: Introductionunclassified

Kronik Hepatit B ve C Enfeksiyonu ile Interlokin-2 (-330) Gen Polimorfizmi Arasindaki Iliskinin Arastirilmasi

2016

GMJ

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ÖZETAmaç: Hepatit B virüs (HBV) ve hepatit C virüs (HCV) enfeksiyonlarının immunopatogenezinde sitokinler oldukça büyük öneme sahiptirler. Th1 hücreleri tarafından salgılanan interlökin-2 (IL-2) hem immun sistemin aktivasyonunda ve hem de homeostazın düzenlenmesinde önemli rol oynayan, immun sistem üzerinde oldukça geniş spektrumlu etkiye sahip olan bir sitokindir. IL-2 -330 gen polimorfizmi ile hastalık ilişkisinin araştırıldığı çok sayıda çalışmaya rağmen, bu sitokin polimorfizminin HBV ve HCV enfeksiyonlarının immunopatogenezindeki rolünü araştıran oldukça az sayıda çalışma bulunmaktadır. Bu çalışmada kronik hepatit B ve C enfeksiyonu ile IL-2 -330 gen polimorfizmi arasındaki ilişkinin belirlenmesi amaçlanmıştır. Yöntem: Çalışmaya kronik hepatit B'li 139 hasta, kronik hepatit C'li 101 hasta ve kontrol grubu olarak 87 sağlıklı birey dahil edilmiştir. Hasta ve kontrol grubundaki bireylerden yaklaşık 2 ml EDTA'lı tüplere kan alınmış ve DNA izolasyon kiti kullanılarak genomik DNA izole edilmiştir. Elde edilen DNA'lardan tek nükleotid polimorfizmi (SNP) polimeraz zincir reaksiyonu-confronting twopair primers (PCR-CTPP) yöntemi ile araştırılmıştır. Bulgular: Hepatit B hasta grubunda IL-2 -330 TT, GT ve GG genotip sıklığı sırasıyla %23.7, %53.2 ve %23; kontrol grubunda ise %27.6, %50.6 ve %21.8 olarak saptanmıştır (p>0.05). Hepatit C hasta grubunda ise; TT, GT ve GG genotip sıklığı %34.7, %56.4 ve %8.9; kontrol grubunda ise %27.6, %50.6 ve %21.8 olarak saptanmış; GG genotip sıklığı kronik hepatit C hastalarında kontrol grubuna göre daha düşük bulunmuştur (p<0.05).T allel sıklığı kronik hepatit B'li hastalarda %50.4, kontrol grubunda %52.9; G alleli ise hasta grubunda %49.6, kontrol grubunda ise %47.1 idi (p>0.05). Kronik hepatit C'li hastalarda ise T allel sıklığı %69.4, kontrol grubunda ise %52.9, G alleli ise hasta grubunda %30.6, kontrol grubunda ise %47.1 olarak belirlenmiştir (p<0.05). Sonuç: Çalışmamızda kronik hepatit B ile IL-2 geninin -330 pozisyonundaki polimorfizmi arasında istatistiksel olarak anlamlı bir ilişki saptanmazken, GG genotipi ile kronik hepatit C arasında anlamlı bir ilişki bulunmuştur. Bulgularımıza göre Türk popülasyonunda IL-2 geni -330 pozisyonundaki GG genotipi ve G alleli kronik hepatit C'de koruyucu etkiye sahip olabilir, ancak daha kapsamlı çalışmalar konunun aydınlatılmasına katkı sağlayabilir. ABSTRACTObjective: Cytokines has an important role in the immunopathogenesis of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. Interleukin-2 (IL-2) secreted by Th1 cells which plays an important role in regulating both in activation of the immune system and homeostasis, is a cytokine having a wide spectrum of effects on the immune system. Although there are many studies investigating the relationship between IL-2 -330 gene polymorphism and diseases, a few studied was found to investigate the role in the immunopathogenesis of HBV and HCV infections of this cytokine polymorphisms. This study was aimed to determine the relationship between IL-2 -330 gene polymorphisms and chroni...

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“…During the subsequent screening and selection steps of duplicate checks, title and abstract checks, and text reviews, 209 articles were excluded according to the eligibility criteria. Finally, fifteen articles (36 independent case-control studies) involving 5,971 patients and 8,913 controls were included in this meta-analysis ( Figure 1) [5,13,[25][26][27][28][29][30][31][32][33][34][35][36][37]. Of these studies, nine case-control studies focused on -1082A>G [5, 13, 25-28, 31, 34], sixteen case-control studies focused on -819T>C [5, 13, 25-32, 35, 36], and eleven case-control studies focused on -592A>C [13, 26-29, 31, 33, 35, 37].…”

Section: Study Characteristics a Total Of 224 Potential Articlesmentioning

confidence: 99%

Association between Interleukin-10 Gene Polymorphisms and Behcet’s Disease Susceptibility: Evidence from a Meta-Analysis

Huang

et al. 2020

Journal of Immunology Research

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Epidemiological studies have demonstrated that interleukin-10 (IL-10) polymorphisms may be associated with the development of Behcet’s disease (BD). However, the published results were inconsistent. Therefore, this meta-analysis was conducted to derive a more precise relationship between IL-10 polymorphisms and BD susceptibility. Online databases (PubMed, Embase, Science Citation Index (SCI), CNKI, and WanFang) were searched to identify eligible studies. Odds ratio (OR) and a 95% confidence interval (CI) were applied to assess the relationship strength between IL-10 -1082A>G (rs1800896), -819T>C (rs1800871), and -592A>C (rs1800872) polymorphisms and BD susceptibility. Publication bias, sensitivity, and cumulative analyses were conducted to measure the robustness of our findings. Finally, fifteen articles (36 independent case-control studies) involving 5,971 patients and 8,913 controls were included. Overall, significant associations between -819T>C polymorphisms and BD risk were observed in the total population (C vs. T: OR=0.72, 95%CI=0.67‐0.77, P<0.01, I2=36.6%; TC vs. TT: OR=0.73, 95%CI=0.66‐0.80, P<0.01, I2=23.0%; CC vs. TT: OR=0.52, 95%CI=0.39‐0.70, P<0.01, I2=53.7%; TC+CC vs. TT: OR=0.67, 95%CI=0.61‐0.71, P<0.01, I2=22.1%; and CC vs. TT+TC: OR=0.66, 95%CI=0.53‐0.82, P<0.01, I2=57.8%). Moreover, the IL-10 -592 A>C polymorphism and the ACC haplotype exhibited a significant, protective effect against BD susceptibility. In summary, our meta-analysis suggested that IL-10 gene polymorphisms may play a salient role for BD development.

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The impact of the IL-1β, IL-1Ra, IL-2, IL-6 and IL-10 gene polymorphisms on the development of Behcet's disease and their association with the phenotype

Cited by 4 publications

References 18 publications

Investigation of the role of interleukin 1 receptor antagonist VNTR variant on the Behçet's disease

Investigation of the role of interleukin 1 receptor antagonist VNTR variant on the Behçet's disease

Kronik Hepatit B ve C Enfeksiyonu ile Interlokin-2 (-330) Gen Polimorfizmi Arasindaki Iliskinin Arastirilmasi

Association between Interleukin-10 Gene Polymorphisms and Behcet’s Disease Susceptibility: Evidence from a Meta-Analysis

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