The impact of the lacto-ovo vegetarian diet on the erythrocyte superoxide dismutase activity: a study in the Romanian population

Abstract

The duration of LOV diet has impact only on SOD activity. Further researches, both in vitro and in vivo, are necessary to understand the underlying molecular mechanism.

Vitamin B12 in Relation to Oxidative Stress: A Systematic Review

“…Studies were conducted in a wide range of countries (Table 1). The overall age of study groups ranged from mean 42.4 ± 15.2 years [48] to median 52 years (Q1–Q3 44–56 years) [47] for RCTs, and from mean 28.4 ± 8.6 years [51] to ≥70 years [52] for observational studies.…”

“…The human populations under investigation showed a wide range of (disease) phenotypes. Boanca et al [51] compared lacto-ovo vegetarians with omnivores and three studies investigated diabetic patients [47,53,54]. Other disease phenotypes under investigation in CC designs included cardiovascular disease [55], schizophrenia [56], and chronic myeloproliferative disorder [57].…”

“…If the median, range, and sample size were reported, mean ± SD were estimated according to Hozo et al [63]. Three studies supported the antioxidant properties of B12 [53,55,59], one does not [58], and one presented unclear results [51]. Due to heterogeneity in the study populations and oxidative stress markers, grouping of absolute results was not possible.…”

“…Two observational studies showed conflicting results compared to the overall trend. Boanca et al [51] found in their CC study that lacto-ovo vegetarians had significantly lower serum B12, MDA, and SOD compared to non-vegetarians. Concomitant lower MDA, a product of lipid peroxidation, and SOD, a superoxide scavenger, appears paradoxical as it indicates lower downstream oxidative damage and lower antioxidant capacity [19].…”

“…Concomitant lower MDA, a product of lipid peroxidation, and SOD, a superoxide scavenger, appears paradoxical as it indicates lower downstream oxidative damage and lower antioxidant capacity [19]. Although mechanistic explanations for the conflicting observations by Boanca et al remain unclear [51], they may underline the complex nature of oxidative stress [21]. Finally, Güney et al [58] showed no difference in oxidative stress markers between B12 deficient patients and healthy volunteers.…”