The impact of thrombocytosis on clinicopathological prognostic factors and survival in patients with vulvar cancer

Uysal, Ahmet; Gültekin, Emre; Taner, Cüneyt Eftal; Mun, Semih; Yidirim, Yusuf

doi:10.17772/gp/1603

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There were only three (n=3) studies that met the search protocol [ 4 - 6 ]. Table 1 summarizes the key findings of all PubMed-indexed, peer-reviewed, and English-published literature on the role of preoperative thrombocytosis as a prognostic factor in patients with vulvar SCC until February 20, 2018.…”

Section: Reviewmentioning

confidence: 99%

“…In 2013, from Turkey (Aegean Maternity and Teaching Hospital, Izmir), Uysal and associates [ 6 ] reported their experience of preoperative thrombocytosis as a prognostic factor in 41 patients with vulvar SCC. Preoperative thrombocytosis was defined as a platelet count >450 x 10 9 /L.…”

Section: Reviewmentioning

confidence: 99%

“…Thus, in reference to the body of existing literature [ 4 - 6 ], it can be deduced that preoperative thrombocytosis does not emerge as a substantial independent prognostic factor of DFS and OS in patients with vulvar SCC. Nevertheless, the interpretation of this conclusion should be done with extreme cautiousness [ 7 ].…”

Section: Reviewmentioning

confidence: 99%

See 2 more Smart Citations

Preoperative Elevated Platelet Count as a Prognostic Factor in Vulvar Squamous Cell Cancer: A Mini-review

Abu‐Zaid

Alomar

Salem

2018

Cureus

View full text Add to dashboard Cite

Preoperative thrombocytosis has been shown to be a marker of advanced disease and poor survival in gynecologic malignancies, specifically endometrial, ovarian, and cervical cancers. The aim of this study is to provide a focused mini-review on all the existing literature concerning the role of preoperative thrombocytosis as a prognostic factor in vulvar squamous cell cancer (SCC). A PubMed search (until February 20, 2018) of all peer-reviewed and English-published articles was conducted using the following keywords: platelet, thrombocytosis, and vulvar cancer. Only three studies met the search protocol. It is concluded that preoperative thrombocytosis does not emerge as a substantial independent prognostic factor of disease-free survival (DFS) and overall survival (OS) in patients with vulvar SCC. Nevertheless, the interpretation of this conclusion should be done with extreme cautiousness. This can be ascribed to the heterogeneity of the reported data across the three studies, especially concerns pertaining to methodological designs. Additional related uniform studies are needed, so that data can be usefully pooled into a well-characterized systematic review/meta-analysis study, in order to devise valid mathematically proven conclusions. For now, International Federation of Gynecology and Obstetrics/ Fédération Internationale de Gynécologie et d’Obstétrique staging (FIGO staging) and inguino-femoral lymph node involvement continue to be the most established independent prognostic factors of DFS and OS in patients with vulvar SCC.

show abstract

Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%