The impact of thyroid autoantibodies on the cycle outcome and embryo quality in women undergoing intracytoplasmic sperm injection

Tokgöz, Vehbi Yavuz; Isim, Berker; Tekin, Ahmet

doi:10.1186/s43043-020-00023-6

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…ese monoclonal antibodies block immune checkpoints and release T cells to fight cancer [9][10][11]. Immune checkpoints also attach importance to maintaining immune self-tolerance and preventing autoimmune diseases.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Thyroid Dysfunction in Patients with Advanced Non-Small-Cell Lung Cancer Treated with PD-1 Antibody

Zhang

Lou

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To analyze the health status of thyroid function in patients with advanced non-small-cell lung cancer cured with PD-1 antibody and to explore the risk factors of thyroid dysfunction. Methods. 100 patients from Hunan Provincial People’s Hospital with advanced non-small-cell lung cancer hospitalized from January 2021 to March 2022 were selected. All patients were treated with a PD-1 antibody. The differences in sex, age, operation history, chemotherapy history, radiotherapy history, and thyroid nodules between patients with abnormal thyroid function and normal thyroid function after treatment were compared. Moreover, the risk factors of thyroid dysfunction were analyzed. Results. The proportion of women in the normal thyroid function group was lower compared to the abnormal thyroid function group. And the proportion of patients with the course of the disease within 1 year in the normal thyroid function group was higher compared to the abnormal thyroid function group. The incidence of thyroid color ultrasound nodules in the normal thyroid function group was remarkably higher compared to the abnormal thyroid function group ( P < 0.05 ). The proportion of patients with nodules in the abnormal thyroid function group was remarkably higher compared to the normal thyroid function group. Among the 36 patients who developed abnormal thyroid function, the incidence of hyperthyroidism (hyperthyroidism) and subclinical hyperthyroidism (subclinical hyperthyroidism) was 33.33%. The incidence of hypothyroidism (hypothyroidism) and hypothyroidism (subclinical hypothyroidism) was 66.66%. The cumulative incidence rates after 3 cycles, 6 cycles, and 12 cycles were 63.88%, 83.33%, and 94.44%, respectively. T4 and FT3 levels decreased more than the normal group following therapy. The results showed that females, course of disease more than one year, and thyroid nodule were independent risk factors of thyroid dysfunction. Conclusion. Female gender, disease duration of more than 1 year, and thyroid nodules were independent risk factors for thyroid dysfunction after PD-1 antibody therapy. Therefore, clinical treatment should focus on patients with the above factors, and early intervention should be implemented to avoid the occurrence of thyroid dysfunction after PD-1 antibody treatment.

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Section: Introductionmentioning

confidence: 99%

Risk Factors for Thyroid Dysfunction in Patients with Advanced Non-Small-Cell Lung Cancer Treated with PD-1 Antibody

Zhang

Lou

2022

Evidence-Based Complementary and Alternative Medicine

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“…Patients with anti-thyroid antibody positivity had fewer high-quality embryos present, although this difference did not achieve statistical significance (56.5% vs. 67.8%, P=0.09). Except for the miscarriage rate based on the TSH threshold, there were no significant changes in the subgroup analysis (10) .…”

Section: Discussionmentioning

confidence: 79%

“…Anti-thyroid antibody-positive individuals had a considerably lower incidence of fertilization than antithyroid antibody-negative patients, according to Tokgoz and his colleagues (10) (97.1 (SD 10.5) vs. 91.5 (SD 19.8), respectively, P=0.003). The incidence of clinical pregnancy, miscarriage, and continuing pregnancy were comparable among research groups.…”

Section: Discussionmentioning

confidence: 91%

Impact of Thyroid Antibodies on In Vitro Fertilization/Intracytoplasmic Sperm Injection Outcomes

Abdel-Raheem¹,

Abbas²,

Elsayed³

2022

The Egyptian Journal of Hospital Medicine

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Background: Thyroid autoimmunity (TAI) and the success of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) have been linked in a number of studies; however, the findings are still debatable. Objective: The aim of the current study is to examine whether the presence of thyroid antibodies affects IVF/ICSI results, such as the number of retrieved oocytes, embryo quality, clinical pregnancy rate, and miscarriage rate. Furthermore, subgroup analysis was performed to examine the relationship between the kinds and titers of thyroid antibodies and pregnancy outcomes during IVF/ICSI. Patients and methods: A retrospective cohort study was conducted on 80 infertile women who were nominated for IVF/ICSI; 40 cases with negative and another 40 with positive anti-thyroid antibodies. We compared between both groups regarding clinical/chemical pregnancy rate, doses/duration of induction of ovulation, number of collected oocytes, fertilization rate, quality of transferred embryos and miscarriage rate. Results: Among enrolled cases; 21 (52.5%) had positive anti-TG, 28 (70.0%) had positive anti-TPO and cases that had both anti-TG and TPO were 9 (22.5%), while those who had either anti-TG or TPO were 31 (77.5%). There were no significant differences between study groups regarding embryo quality, clinical/biochemical pregnancy rates, embryo cleavage, induction duration, endometrial thickness and number of fertilized/M2 oocytes or transferred embryos. However, the number of used induction ampoules and abortion rate were statistically significant increased among pregnant women. Conclusion: Infertile women with TAI treated with ICSI had no increased risk of poor IVF/ICSI outcomes except significant increased risk for a first-trimester miscarriage compared with women without TAI.

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Recent insights into the impact of immune dysfunction on reproduction in autoimmune thyroiditis

Zhu

Xie

et al. 2021

Clinical Immunology

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The impact of thyroid autoantibodies on the cycle outcome and embryo quality in women undergoing intracytoplasmic sperm injection

Cited by 5 publications

References 33 publications

Risk Factors for Thyroid Dysfunction in Patients with Advanced Non-Small-Cell Lung Cancer Treated with PD-1 Antibody

Risk Factors for Thyroid Dysfunction in Patients with Advanced Non-Small-Cell Lung Cancer Treated with PD-1 Antibody

Impact of Thyroid Antibodies on In Vitro Fertilization/Intracytoplasmic Sperm Injection Outcomes

Recent insights into the impact of immune dysfunction on reproduction in autoimmune thyroiditis

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