The impact of time, legislation, and geography on the epidemiology of traumatic brain injury

Chiu, Wen Ta; Huang, Sheng Jean; Tsai, Shin Han; Lin, Jia Wei; Tsai, Ming Da; Lin, T.; Huang, William C.

doi:10.1016/j.jocn.2006.08.004

Cited by 70 publications

(70 citation statements)

References 16 publications

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“…7,13,25 In Taiwan, an estimated 52,000 TBIs occur annually, and up to 25% of them are fatal. 5 Traumatic brain injury can result in substantial and lifelong cognitive, physical, and behavioral impairments that require long-term access to health care and disability services. 9,21 However, predicting the level of health care service utilization associated with TBI is difficult because of its widely varying rates and extent of recovery.…”

Section: ©Aans 2014mentioning

confidence: 99%

Trends and outcome predictors after traumatic brain injury surgery: a nationwide population-based study in Taiwan

Shi¹,

Hwang

Lee³

et al. 2014

JNS

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Object.The authors sought to analyze trends in hospital resource utilization and mortality rates in a population of patients who had received traumatic brain injury (TBI) surgery.Methods. This nationwide population-based cohort study retrospectively analyzed 18,286 patients who had received surgical treatment for TBI between 1998 and 2010. The multiple linear regression model and Cox proportional hazards model were used for multivariate assessment of outcome predictors.Results. The prevalence rate of surgical treatment for patients with TBI gradually but significantly (p < 0.001) increased by 47.6% from 5.0 per 100,000 persons in 1998 to 7.4 per 100,000 persons in 2010. Age, sex, DeyoCharlson comorbidity index score, hospital volume, and surgeon volume were significantly associated with TBI surgery outcomes (p < 0.05). Over the 12-year period analyzed, the estimated mean hospital treatment cost increased 19.06%, whereas the in-hospital mortality rate decreased 10.9%. The estimated mean time of overall survival after TBI surgery (± SD) was 83.0 ± 4.2 months, and the overall in-hospital and 1-, 3-, and 5-year survival rates were 74.5%, 67.3%, 61.1%, and 57.8%, respectively.Conclusions. These data reveal an increased prevalence of TBI, especially in older patients, and an increased hospital treatment cost but a decreased in-hospital mortality rate. Health care providers and patients should recognize that attributes of the patient and of the hospital may affect hospital resource utilization and the mortality rate. These results are relevant not only to other countries with similar population sizes but also to countries with larger populations. (http://thejns.org/doi/abs/10.3171/2014.8.JNS131526) KeY worDS • traumatic brain injury • trends • predictors • hospital resource utilization • mortality rateAbbreviations used in this paper: BNHI = Bureau of National Health Insurance; DCCI = Deyo-Charlson comorbidity index; ICD-9-CM = International Classification of Diseases, Ninth Revision, Clinical Modification; IQR = interquartile range; LOS = length of stay; TBI = traumatic brain injury.* Drs. K. T. Lee and Lin contributed equally to this study.

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Section: ©Aans 2014mentioning

confidence: 99%

Trends and outcome predictors after traumatic brain injury surgery: a nationwide population-based study in Taiwan

Shi¹,

Hwang

Lee³

et al. 2014

JNS

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“…[1][2][3][4][5][6][7][8][9] The incidence of TBI in the United States is comparable to that of stroke but affects younger people, thus resulting in a greater healthcare burden. 10 TBI covers a wide range of injuries, from mild to moderate and severe.…”

Section: Introductionmentioning

confidence: 99%

A Novel, Ultrasensitive Assay for Tau: Potential for Assessing Traumatic Brain Injury in Tissues and Biofluids

Rubenstein

Chang

Davies

et al. 2015

Journal of Neurotrauma

103

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Traumatic brain injury (TBI) is a cause of death and disability and can lead to tauopathy-related dementia at an early age. Pathologically, TBI results in axonal injury that is coupled to tau hyperphosphorylation, leading to microtubule instability and tau-mediated neurodegeneration. This suggests that the forms of this protein might serve as neuroinjury-related biomarkers for diagnosis of injury severity and prognosis of the neurological damage prior to clinical expression. We initially determined whether we could detect tau in body fluids using a highly sensitive assay. We used a novel immunoassay, enhanced immunoassay using multi-arrayed fiberoptics (EIMAF) either alone or in combination with rolling circle amplification (a-EIMAF) for the detection of total (T) and phosphorylated (P) tau proteins from brains and biofluids (blood, CSF) of rodents following controlled cortical impact (CCI) and human patients post severe TBI (sTBI). This assay technology for tau is the most sensitive to date with a detection limit of approximately 100 ag/mL for either T-tau and Ptau. In the rodent models, T-tau and P-tau levels in brain and blood increased following CCI during the acute phase and remained high during the chronic phase (30 d). In human CSF samples, T-tau and P-tau increased during the sampling period (5-6 d). T-tau and P-tau in human serum rose during the acute phase and decreased during the chronic stage but was still detectable beyond six months post sTBI. Thus, EIMAF has the potential for assessing both the severity of the proximal injury and the prognosis using easily accessible samples.

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“…Also, in an international investigation, we can be seen this difference between the two gender of patients (26)(27)(28). It should be noted that this ratio is changed to increase the percentage of women compared to men, that is probably due to the more use of motor vehicles, especially motorcycles by women (24).…”

Section: Discussionmentioning

confidence: 81%

“…These statistics are varying in different societies; results show that the most common brain injury is related to the third decade of life in developed countries (20)(21)(22)(23). Chiu et al revealed that the most common age group 20-29 years in Taiwan (24) and in a study that done in Norway, the most common head injury was reported in the 0-4 and above 75 years age groups.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological, Clinical and Radiological Characteristics of Patients with Head Trauma

Moghadam-Ahmadi

Vakilian

Farahmand

et al. 2017

IMMINV

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Background: Head injury has been recognized as a major public health problem and is a frequent cause of death and disability in young people and makes considerable demands on health services. Motor vehicle accidents are the major causes of traumatic brain injury (TBI) that its occurrence has been increasing in our country in recent years. We decided to study head injury in our region to evaluate the Epidemiological, clinical and radiological features of this health problem. Methods: We reviewed 200 TBI-patients records in Ali Ibn Abi Taleb hospital of Rafsanjan during 2012-2013. A Questionnaire including age, sex, job, the cause of trauma, Glasgow coma scale (GCS), brain computed tomography (CT) scan findings and clinical symptoms for every head trauma patient; was completed. Data were analyzed by SPSS software using Chi-square test and P-value less than 0.05 was considered significant. Results: From the total of 200 patients, 73.5% were males, and 26.5% were females. The most common age group was 20-24 years. The majority of patients were students. Traffic accidents were the major cause of injuries (64.5%), and 35.5% of them were a motorcyclist. The most frequent finding of brain CT scan was skull fracture, and subdural hematoma and 25% of patient had a severe head injury. In clinical symptoms in conscious patients, headache, nausea, vomiting and vertigo was common. Conclusion: This study showed that we should pay more attention to traumatic brain injury young patients who are the most active potential forces of our society. Traffic accidents are the major reason for head injuries. Pay attention to prevention of this accident can perform an important role in decreasing of head injuries.

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The impact of time, legislation, and geography on the epidemiology of traumatic brain injury

Cited by 70 publications

References 16 publications

Trends and outcome predictors after traumatic brain injury surgery: a nationwide population-based study in Taiwan

Trends and outcome predictors after traumatic brain injury surgery: a nationwide population-based study in Taiwan

A Novel, Ultrasensitive Assay for Tau: Potential for Assessing Traumatic Brain Injury in Tissues and Biofluids

Epidemiological, Clinical and Radiological Characteristics of Patients with Head Trauma

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