The impact of tumor stroma on drug response in breast cancer

Dittmer, Jürgen; Leyh, Benjamin

doi:10.1016/j.semcancer.2014.05.006

Cited by 88 publications

(93 citation statements)

References 201 publications

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“…Many studies have suggested the involvement of fibroblasts in chemoresistance [6,31,32]. Desmoplastic reactions, which accumulate dense ECM that may act as a physical barrier to drug penetration, are induced by stromal fibroblasts in tumors [33].…”

Section: Chemoresistancementioning

confidence: 99%

Co-culture of 3D tumor spheroids with fibroblasts as a model for epithelial–mesenchymal transition in vitro

Kim

Lee

Kuh

2015

Experimental Cell Research

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Section: Chemoresistancementioning

confidence: 99%

Co-culture of 3D tumor spheroids with fibroblasts as a model for epithelial–mesenchymal transition in vitro

Kim

Lee

Kuh

2015

Experimental Cell Research

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“…Examples of processes essential to breast cancer progression that depend on non-cancerous components include the induction of angiogenesis, 13,14 establishment of pro-tumor inflammation, 14,15 activation of cancer cells toward invasion and metastasis, 16-18 metabolic deregulation, 19 and avoidance of immune destruction 20 . Significantly, heterotypic interactions can also contribute to drug resistance 21 .…”

Section: Heterotypic Interactions In Breast Cancer and In Vitro Breasmentioning

confidence: 99%

Progress towards understanding heterotypic interactions in multi-culture models of breast cancer

2016

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Microenvironments in primary tumors and metastases include multiple cell types whose dynamic and reciprocal interactions are central to progression of the disease. However, the literature involving breast cancer studied in vitro is dominated by cancer cells in mono-culture or co-cultured with one other cell type. For in vitro studies of breast cancer the inclusion of multiple cell types has led to models that are more representative of in vivo behaviors and functions as compared to more traditional monoculture. Here, we review foundational co-culture techniques and their adaptation to multi-culture (including three or more cell types). Additionally, while macroscale methods involving conditioned media, direct contact, and indirect interactions have been informative, we examined many advances that have been made more recently using microscale systems with increased control over cellular and structural complexity. Throughout this discussion we consider the benefits and limitations of current multi-culture methods and the significant results they have produced.

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“…Furthermore, chemotherapy, radiotherapy, and even surgical resection, may further expand TME heterogeneity as all of these interventions will influence, directly and indirectly, the survival and functional contribution of the cellular components of the TME. For example, it has only recently been better appreciated that chemotherapeutic drugs aimed to suppress proliferation of (cancer) cells will have a significant impact on the stroma 12 ; and radiotherapy may alter TME composition and impact response to therapeutic irradiation 13 . In these settings, the functional diversity of the TME may be further enhanced by bystander effects that may tip the dynamic balance of the tumor suppressing vs. tumor promoting roles of TME components (Figure 2).…”

Section: The Tumor Microenvironment: Definition and Heterogeneitymentioning

confidence: 99%

Imaging the Tumor Microenvironment

LeBleu

2015

The Cancer Journal

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The tumor microenvironment is a complex, heterogeneous, and dominant component of solid tumors. Cancer imaging strategies of a subset of characteristics of the tumor microenvironment are under active development and currently used modalities and novel approaches are summarized here. Understanding the dynamic and evolving functions of the tumor microenvironment is critical to accurately inform imaging and clinical care of cancer. Novel insights into distinct roles of the tumor microenvironment in cancer progression urge careful interpretation of imaging data and impel the development of novel modalities.

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The impact of tumor stroma on drug response in breast cancer

Cited by 88 publications

References 201 publications

Co-culture of 3D tumor spheroids with fibroblasts as a model for epithelial–mesenchymal transition in vitro

Co-culture of 3D tumor spheroids with fibroblasts as a model for epithelial–mesenchymal transition in vitro

Progress towards understanding heterotypic interactions in multi-culture models of breast cancer

Imaging the Tumor Microenvironment

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