The impact of unilateral salpingectomy on antral follicle count and ovarian response in ICSI cycles: comparison of contralateral side

Demır, Berfu; Bozdağ, Gürkan; Şengül, Özlem; Kahyaoğlu, Serkan; Mümüşoğlu, Sezcan; Zengin, Dila

doi:10.3109/09513590.2016.1161741

Cited by 8 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The surgical removal of hydrosalpinx prior to IVF improves PRs and reproductive outcomes. 78 In addition, salpingectomy does not affect the ovarian response, nor reduces the antral follicle count. 79 Laparoscopic salpingectomy is the optimal surgical approach; therefore, it should be recommended.…”

Section: Discussionmentioning

confidence: 99%

Effects of Hydrosalpinx on Endometrial Implantation Failures: Evaluating Salpingectomy in Women Undergoing in vitro fertilization

Palagiano

Cozzolino

Ubaldi

et al. 2021

Rev Bras Ginecol Obstet

View full text Add to dashboard Cite

Hydrosalpinx is a disease characterized by the obstruction of the salpinx, with progressive accumulation in the shape of a fluid-filled sac at the distal part of the tuba uterina, and closed to the ovary. Women with hydrosalpinges have lower implantation and pregnancy rates due to a combination of mechanical and chemical factors thought to disrupt the endometrial environment. Evidence suggests that the presence of hydrosalpinx reduces the rate of pregnancy with assisted reproductive technology. The main aim of the present is review to make an overview of the possible effects of hydrosalpinx on in vitro fertilization (IVF). We conducted a literature search on the PubMed, Ovid MEDLINE, and Google Scholar data bases regarding hydrosalpinx and IVF outcomes. Hydrosalpinx probably has a direct toxic effect on sperm motility and on the embryos. In addition, the increasing liquid inside the salpinges could alter the mechanisms of endometrial receptivity. The window of endometrial receptivity is essential in the implantation of blastocysts, and it triggers multiple reactions arising from the endometrium as well as the blastocysts. Hydrosalpinx could influence the expression of homeobox A10 (HOXA10) gene, which plays an essential role in directing embryonic development and implantation. Salpingectomy restores the endometrial expression of HOXA10; therefore, it may be one mechanism by which tubal removal could result in improved implantation rates in IVF. In addition, salpingectomy does not affect the ovarian response, nor reduces the antral follicle count. Further studies are needed to establish the therapeutic value of fluid aspiration under ultrasonographic guidance, during or after oocyte retrieval, in terms of pregnancy rate and ongoing pregnancy.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Hydrosalpinx on Endometrial Implantation Failures: Evaluating Salpingectomy in Women Undergoing in vitro fertilization

Palagiano

Cozzolino

Ubaldi

et al. 2021

Rev Bras Ginecol Obstet

View full text Add to dashboard Cite

show abstract

“…Pereira et al suggested that IVF-ET patients who had a previous unilateral salpingectomy required higher gonadotropin (Gn) doses and longer stimulation duration when undergoing a controlled ovarian stimulation (COS) compared to patients who had not undergone salpingectomy [8]. However, some investigators showed that there was no significant influence on ovarian reserve, ovarian response, or the number of retrieved oocytes before and after salpingectomy [9][10][11][12][13][14][15][16]. With advancing female age, declines in number and quality of oocytes are the primary reasons for decreasing IVF outcomes, especially in terms of live birth rates [17].…”

Section: Introductionmentioning

confidence: 99%

Salpingectomy may decrease antral follicle count but not live birth rate for IVF-ET patients aged 35–39 years: a retrospective study

et al. 2020

View full text Add to dashboard Cite

Purpose: Problems with fallopian tubes are one of the main reasons for women to undergo in vitro fertilizationembryo transfer (IVF-ET). A large proportion of women with ectopic pregnancy, fallopian tube obstruction and hydrosalpinx have had one or both fallopian tubes removed by salpingectomy. With increasing age, ovarian reserve deteriorates, the numbers of retrieved oocytes, available embryos and high-quality embryos are reduced, and the live birth rate for women treated with IVF treatment is affected. Thus, it is important to understand how salpingectomy affects live birth rates for IVF patients of different ages. This study analyzed how patients' age and salpingectomy influenced ovarian reserve, ovarian response and pregnancy outcomes for infertile women undergoing IVF-ET. Methods: A total of 1922 patients that underwent IVF-ET treatment from January 1, 2012, to December 31, 2018, were included in this retrospective study. The patients were divided into two groups according to whether or not they had a previous history of salpingectomy. The salpingectomy (group A, 534 patients) and control groups (group B, 1388 patients) were then further divided into two subgroups according to patient age (age<35 years, and age 35-39 years). Ovarian reserve, ovarian response, and IVF outcomes were investigated for each subgroup. Logistic regression model was used to estimate the relationship between clinical pregnancy and live births and patients' baseline characteristics. Results: In the salpingectomy group, antral follicle counts (AFC) were significantly lower for the subgroup aged 35 to 39 years compared with the control group. But this difference did not appear in women younger than 35 years. In addition, there were no significant differences in levels of basal follicle stimulation hormone (FSH), basal luteinizing hormone (LH), basal estradiol (E 2), total gonadotropins (Gn) dose, duration of Gn, numbers of retrieved oocytes, fertilization rates, numbers of available embryos, live birth rates, clinical pregnancy rates, miscarriage rates, ectopic pregnancy rates, or multiple pregnancy rates between the salpingectomy group and the control group (P > 0.05). Age is a risk factor for the clinical pregnancy and live birth. Conclusion: Salpingectomy may decrease antral follicle count but not live birth rate for IVF-ET patients aged 35-39 years. The increased female age was negative related with clinical pregnancy and live birth.

show abstract

Ovarian Response and in Vitro Fertilization Outcomes After Salpingectomy: Does Salpingectomy Indication Matter?

Pereira

Pryor

Voskuilen-Gonzalez

et al. 2017

Journal of Minimally Invasive Gynecology

View full text Add to dashboard Cite

The impact of unilateral salpingectomy on antral follicle count and ovarian response in ICSI cycles: comparison of contralateral side

Abstract: The study suggests that salpingectomy is not associated with detrimental effects on AFC and ovarian response.

Cited by 8 publications

References 14 publications

Effects of Hydrosalpinx on Endometrial Implantation Failures: Evaluating Salpingectomy in Women Undergoing in vitro fertilization

Effects of Hydrosalpinx on Endometrial Implantation Failures: Evaluating Salpingectomy in Women Undergoing in vitro fertilization

Salpingectomy may decrease antral follicle count but not live birth rate for IVF-ET patients aged 35–39 years: a retrospective study

Ovarian Response and in Vitro Fertilization Outcomes After Salpingectomy: Does Salpingectomy Indication Matter?

Contact Info

Product

Resources

About