The impact of using electrical impedance spectroscopy (ZedScan) on the performance of colposcopy in diagnosing high grade squamous lesions of the cervix

Muszynski, Cheryl A.; Dupont, Elisabeth; Vaysse, B.; Lanta, S.; Tidy, John; Sergent, F.; Gondry, J.

doi:10.1016/j.jogoh.2017.08.007

Cited by 12 publications

(25 citation statements)

References 21 publications

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“…174 Electrical impedance spectroscopy, which measures TEP through the skin, is inexpensive and easily implemented clinically as it is already used for applications such as cardiac cycle imaging, gastrointestinal function monitoring, and skin cancer detection. [185][186][187] Understanding the significance and role of bioelectric changes at the cellular and tissue level can be used to further the development of this technology to detect changes in the breast tissue using electric potential, both earlier and with greater accuracy than current methods.…”

Section: Bioelectricity and Metastasis 123mentioning

confidence: 99%

Bioelectric Control of Metastasis in Solid Tumors

2019

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As the leading cause of death in cancer, there is an urgent need to develop treatments to target the dissemination of primary tumor cells to secondary organs, known as metastasis. Bioelectric signaling has emerged in the last century as an important controller of cell growth, and with the development of current molecular tools we are now beginning to identify its role in driving cell migration and metastasis in a variety of cancer types. This review summarizes the currently available research for bioelectric signaling in solid tumor metastasis. We review the steps of metastasis and discuss how these can be controlled by bioelectric cues at the level of a cell, a population of cells, and the tissue. The role of ion channel, pump, and exchanger activity and ion flux is discussed, along with the importance of the membrane potential and the relationship between ion flux and membrane potential. We also provide an overview of the evidence for control of metastasis by external electric fields (EFs) and draw from examples in embryogenesis and regeneration to discuss the implications for endogenous EFs. By increasing our understanding of the dynamic properties of bioelectric signaling, we can develop new strategies that target metastasis to be translated into the clinic.

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Section: Bioelectricity and Metastasis 123mentioning

confidence: 99%

Bioelectric Control of Metastasis in Solid Tumors

2019

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“…EIS is sensitive to the cellular structure of the epithelium and offers information that is not available to visual examination. ZedScan incorporates EIS and can be used as a real time adjunct to colposcopy with multiple studies confirming increased detection of HG-CIN [5][6][7][8][9][10][11]. However, data from clinical trials and cohort studies are not always confirmed when a technology is implemented across multiple healthcare settings with variations in disease prevalence.…”

Section: Introductionmentioning

confidence: 99%

Increased detection of high grade CIN, when using electrical impedance spectroscopy as an adjunct to routine colposcopy, is maintained when used across international boundaries: Prospective data from nine European countries

Tidy

Brown

2022

European Journal of Obstetrics & Gynecology and Reproductiv

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“…They reported a sensitivity of 92% and a specificity of 92% in differentiating patients with normal epithelium from those with cervical intraepithelial neoplasia. Muszyński et al [14] recruited 91 women aged 33 years on average, with a range between 23 to 61 years. They found that using ZedScan as an additional diagnostic procedure with colposcopies in comparison to colposcopies alone increases sensitivity from 61.3% to 93.3% for detecting high-grade SIL but reduces specificity from 80% to 34.4%.…”

Section: Discussionmentioning

confidence: 99%

Use of electrical impedance spectroscopy as an adjunct to colposcopy in a pathway of cervical intraepithelial neoplasia diagnostics

et al. 2019

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Objectives: Screening with cytology decreases cervical cancer burden, but new methods have emerged. We assessed the diagnostic value of electrical impedance spectroscopy (EIS) in the real-world gynecological setting. The study aimed to determine the diagnostic usefulness of EIS used as an adjunct to colposcopies in the diagnosis of high-grade squamous intraepithelial lesions in women with abnormal cytology findings. Material and methods:A cross-sectional, single center, observational study considered 143 women. All were subjected to a colposcopy and EIS with ZedScan. ZedScan-guided or colposcopically-guided biopsies were carried out.Results: Data from 118 women were analyzed. The average age of the included women was 38.29 ± 12.52 years (range: 22-86 years). Overall, 27 had a diagnosis of CIN2+ and above on histopathological examination, 99 had low-grade colposcopy results, 18 had high-grade colposcopy results, and 80 had positive ZedScan examination. No adverse events related to the examination with ZedScan were observed. EIS used as an adjunct to colposcopies showed sensitivity of 96.30% (95% CI: 81.03-99.91) and specificity of 39.56% (95% CI: 29.46-50.36), and accuracy of 52.54% (95% CI: 43.15-61.81). The procedure allowed to detect 11 additional cases with positive histo-pathological result in comparison to colposcopies alone. Conclusions:Colposcopies performed with ZedScan as an adjunct were effective in detecting high-grade cervical lesions. Advantages of ZedScan include real-time result display, no additional diagnostic burden posed on the patient, and good safety profile. Studies on large patient cohorts are needed for further evaluations of this diagnostic procedure and factors which may affect its diagnostic accuracy.

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The impact of using electrical impedance spectroscopy (ZedScan) on the performance of colposcopy in diagnosing high grade squamous lesions of the cervix

Cited by 12 publications

References 21 publications

Bioelectric Control of Metastasis in Solid Tumors

Bioelectric Control of Metastasis in Solid Tumors

Increased detection of high grade CIN, when using electrical impedance spectroscopy as an adjunct to routine colposcopy, is maintained when used across international boundaries: Prospective data from nine European countries

Use of electrical impedance spectroscopy as an adjunct to colposcopy in a pathway of cervical intraepithelial neoplasia diagnostics

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